Seroprevalence and asymptomatic carrier status of SARS-CoV-2 in Wuhan City and other places of China.
Wuhan City (WH) in China was the first place to report COVID-19 in the world and the outbreak of COVID-19 was controlled in March of 2020 in WH. It is unclear what percentage of people were infected with SARS-CoV-2 and what percentage of population is carriers of SARS-CoV-2 in WH. We retrospectively...
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ftdoajarticles:oai:doaj.org/article:e97b6c106b16472d9c01ed1e3eba3f3b 2023-05-15T15:16:18+02:00 Seroprevalence and asymptomatic carrier status of SARS-CoV-2 in Wuhan City and other places of China. Shuhui Duan Meiying Zhou Wen Zhang Jianwei Shen Rui Qi Xiangrong Qin Hao Yu Chuanmin Zhou Qing Hu Xue-Jie Yu 2021-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0008975 https://doaj.org/article/e97b6c106b16472d9c01ed1e3eba3f3b EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0008975 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008975 https://doaj.org/article/e97b6c106b16472d9c01ed1e3eba3f3b PLoS Neglected Tropical Diseases, Vol 15, Iss 1, p e0008975 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0008975 2022-12-31T07:48:33Z Wuhan City (WH) in China was the first place to report COVID-19 in the world and the outbreak of COVID-19 was controlled in March of 2020 in WH. It is unclear what percentage of people were infected with SARS-CoV-2 and what percentage of population is carriers of SARS-CoV-2 in WH. We retrospectively analyzed the SARS-CoV-2 IgG and IgM antibody positive rates in 63,107 healthy individuals from WH and other places of China using commercial colloidal gold detection kits from March 6 to May 3, 2020. Statistical approaches were utilized to explore the difference and correlation for the seropositive rate of IgG and IgM antibody on the basis of sex, age group, geographic region and detection date. The total IgG and IgM antibody positive rate of SARS-CoV-2 was 1.68% (186/11,086) in WH, 0.59% (226/38,171) in Hubei Province without Wuhan (HB), and 0.38% (53/13,850) in the nation except for Hubei Province (CN), respectively. The IgM positive rate was 0.46% (51/11,086) in WH, 0.13% (51/38,171) in HB, and 0.07% (10/13,850) in CN. The incidence of IgM positive rates in healthy individuals increased from March 6 to May 3, 2020 in WH. Female and older age had a higher probability of becoming infected than males (OR = 1.34; 95% CI: 1.08-1.65) or younger age (OR = 2.25; 95% CI: 1.06-4.78). The seroprevalence of SARS-CoV-2 was relatively low in WH and other places of China, but it is significantly high in WH than other places of China; a large amount of asymptomatic carriers of SARS-CoV-2 existed after elimination of clinical cases of COVID-19 in Wuhan City. Therefore, SARS-CoV-2 may exist in a population without clinical cases for a long period. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 15 1 e0008975 |
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Directory of Open Access Journals: DOAJ Articles |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Shuhui Duan Meiying Zhou Wen Zhang Jianwei Shen Rui Qi Xiangrong Qin Hao Yu Chuanmin Zhou Qing Hu Xue-Jie Yu Seroprevalence and asymptomatic carrier status of SARS-CoV-2 in Wuhan City and other places of China. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Wuhan City (WH) in China was the first place to report COVID-19 in the world and the outbreak of COVID-19 was controlled in March of 2020 in WH. It is unclear what percentage of people were infected with SARS-CoV-2 and what percentage of population is carriers of SARS-CoV-2 in WH. We retrospectively analyzed the SARS-CoV-2 IgG and IgM antibody positive rates in 63,107 healthy individuals from WH and other places of China using commercial colloidal gold detection kits from March 6 to May 3, 2020. Statistical approaches were utilized to explore the difference and correlation for the seropositive rate of IgG and IgM antibody on the basis of sex, age group, geographic region and detection date. The total IgG and IgM antibody positive rate of SARS-CoV-2 was 1.68% (186/11,086) in WH, 0.59% (226/38,171) in Hubei Province without Wuhan (HB), and 0.38% (53/13,850) in the nation except for Hubei Province (CN), respectively. The IgM positive rate was 0.46% (51/11,086) in WH, 0.13% (51/38,171) in HB, and 0.07% (10/13,850) in CN. The incidence of IgM positive rates in healthy individuals increased from March 6 to May 3, 2020 in WH. Female and older age had a higher probability of becoming infected than males (OR = 1.34; 95% CI: 1.08-1.65) or younger age (OR = 2.25; 95% CI: 1.06-4.78). The seroprevalence of SARS-CoV-2 was relatively low in WH and other places of China, but it is significantly high in WH than other places of China; a large amount of asymptomatic carriers of SARS-CoV-2 existed after elimination of clinical cases of COVID-19 in Wuhan City. Therefore, SARS-CoV-2 may exist in a population without clinical cases for a long period. |
format |
Article in Journal/Newspaper |
author |
Shuhui Duan Meiying Zhou Wen Zhang Jianwei Shen Rui Qi Xiangrong Qin Hao Yu Chuanmin Zhou Qing Hu Xue-Jie Yu |
author_facet |
Shuhui Duan Meiying Zhou Wen Zhang Jianwei Shen Rui Qi Xiangrong Qin Hao Yu Chuanmin Zhou Qing Hu Xue-Jie Yu |
author_sort |
Shuhui Duan |
title |
Seroprevalence and asymptomatic carrier status of SARS-CoV-2 in Wuhan City and other places of China. |
title_short |
Seroprevalence and asymptomatic carrier status of SARS-CoV-2 in Wuhan City and other places of China. |
title_full |
Seroprevalence and asymptomatic carrier status of SARS-CoV-2 in Wuhan City and other places of China. |
title_fullStr |
Seroprevalence and asymptomatic carrier status of SARS-CoV-2 in Wuhan City and other places of China. |
title_full_unstemmed |
Seroprevalence and asymptomatic carrier status of SARS-CoV-2 in Wuhan City and other places of China. |
title_sort |
seroprevalence and asymptomatic carrier status of sars-cov-2 in wuhan city and other places of china. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0008975 https://doaj.org/article/e97b6c106b16472d9c01ed1e3eba3f3b |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 1, p e0008975 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0008975 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008975 https://doaj.org/article/e97b6c106b16472d9c01ed1e3eba3f3b |
op_doi |
https://doi.org/10.1371/journal.pntd.0008975 |
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PLOS Neglected Tropical Diseases |
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15 |
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1 |
container_start_page |
e0008975 |
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