Antimalarial Activity of Piperine
Malaria remains a public health problem in tropical and subtropical regions. Resistance of Plasmodium falciparum to artemisinins in Southeast Asia is a great concern for disease control and research on discovery and development of new alternative antimalarial drugs is urgently required. In a previou...
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ftdoajarticles:oai:doaj.org/article:e922797fcd2b47589fb8f7cf6ea77f02 2024-09-09T19:26:13+00:00 Antimalarial Activity of Piperine Artitaya Thiengsusuk Phunuch Muhamad Wanna Chaijaroenkul Kesara Na-Bangchang 2018-01-01T00:00:00Z https://doi.org/10.1155/2018/9486905 https://doaj.org/article/e922797fcd2b47589fb8f7cf6ea77f02 EN eng Wiley http://dx.doi.org/10.1155/2018/9486905 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2018/9486905 https://doaj.org/article/e922797fcd2b47589fb8f7cf6ea77f02 Journal of Tropical Medicine, Vol 2018 (2018) Arctic medicine. Tropical medicine RC955-962 article 2018 ftdoajarticles https://doi.org/10.1155/2018/9486905 2024-08-05T17:48:40Z Malaria remains a public health problem in tropical and subtropical regions. Resistance of Plasmodium falciparum to artemisinins in Southeast Asia is a great concern for disease control and research on discovery and development of new alternative antimalarial drugs is urgently required. In a previous study, the fruit of Piper chaba Hunt. was demonstrated to exhibit promising antimalarial activity against the asexual stage of 3D7 (chloroquine-sensitive) and K1 (chloroquine-resistant) P. falciparum clones. The aim of the present study was to further investigate the antimalarial activity of piperine, the major isolated constituent of Piper chaba Hunt. fruits against both P. falciparum clones. The antimalarial activity was determined using SYBR green-I-based assay and morphological change was observed under the light microscope with Giemsa staining. The median IC50 (concentration that inhibits parasite growth by 50%) values of piperine against 3D7 and K1 P. falciparum were 111.5 and 59 μM, respectively. A marked change in parasite morphology was observed within 48 hours of piperine exposure. Results of real-time PCR showed no effect of piperine on modulating the expression of the three genes associated with antimalarial drug resistance in P. falciparum, i.e., pfcrt, pfmdr1, and pfmrp1. Piperine could be a promising candidate for further development as an antimalarial drug based on its antimalarial potency and low risk of resistance development. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Tropical Medicine 2018 1 7 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Artitaya Thiengsusuk Phunuch Muhamad Wanna Chaijaroenkul Kesara Na-Bangchang Antimalarial Activity of Piperine |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
Malaria remains a public health problem in tropical and subtropical regions. Resistance of Plasmodium falciparum to artemisinins in Southeast Asia is a great concern for disease control and research on discovery and development of new alternative antimalarial drugs is urgently required. In a previous study, the fruit of Piper chaba Hunt. was demonstrated to exhibit promising antimalarial activity against the asexual stage of 3D7 (chloroquine-sensitive) and K1 (chloroquine-resistant) P. falciparum clones. The aim of the present study was to further investigate the antimalarial activity of piperine, the major isolated constituent of Piper chaba Hunt. fruits against both P. falciparum clones. The antimalarial activity was determined using SYBR green-I-based assay and morphological change was observed under the light microscope with Giemsa staining. The median IC50 (concentration that inhibits parasite growth by 50%) values of piperine against 3D7 and K1 P. falciparum were 111.5 and 59 μM, respectively. A marked change in parasite morphology was observed within 48 hours of piperine exposure. Results of real-time PCR showed no effect of piperine on modulating the expression of the three genes associated with antimalarial drug resistance in P. falciparum, i.e., pfcrt, pfmdr1, and pfmrp1. Piperine could be a promising candidate for further development as an antimalarial drug based on its antimalarial potency and low risk of resistance development. |
format |
Article in Journal/Newspaper |
author |
Artitaya Thiengsusuk Phunuch Muhamad Wanna Chaijaroenkul Kesara Na-Bangchang |
author_facet |
Artitaya Thiengsusuk Phunuch Muhamad Wanna Chaijaroenkul Kesara Na-Bangchang |
author_sort |
Artitaya Thiengsusuk |
title |
Antimalarial Activity of Piperine |
title_short |
Antimalarial Activity of Piperine |
title_full |
Antimalarial Activity of Piperine |
title_fullStr |
Antimalarial Activity of Piperine |
title_full_unstemmed |
Antimalarial Activity of Piperine |
title_sort |
antimalarial activity of piperine |
publisher |
Wiley |
publishDate |
2018 |
url |
https://doi.org/10.1155/2018/9486905 https://doaj.org/article/e922797fcd2b47589fb8f7cf6ea77f02 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2018 (2018) |
op_relation |
http://dx.doi.org/10.1155/2018/9486905 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2018/9486905 https://doaj.org/article/e922797fcd2b47589fb8f7cf6ea77f02 |
op_doi |
https://doi.org/10.1155/2018/9486905 |
container_title |
Journal of Tropical Medicine |
container_volume |
2018 |
container_start_page |
1 |
op_container_end_page |
7 |
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1809895877530091520 |