Prevalence and correlates of helminth co-infection in Kenyan HIV-1 infected adults.
Deworming HIV-1 infected individuals may delay HIV-1 disease progression. It is important to determine the prevalence and correlates of HIV-1/helminth co-infection in helminth-endemic areas.HIV-1 infected individuals (CD4>250 cells/ul) were screened for helminth infection at ten sites in Kenya. P...
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ftdoajarticles:oai:doaj.org/article:e9212af43a7042f5a366fe26f3c59f22 2023-05-15T15:10:16+02:00 Prevalence and correlates of helminth co-infection in Kenyan HIV-1 infected adults. Judd L Walson Barclay T Stewart Laura Sangaré Loice W Mbogo Phelgona A Otieno Benjamin K S Piper Barbra A Richardson Grace John-Stewart 2010-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000644 https://doaj.org/article/e9212af43a7042f5a366fe26f3c59f22 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC2846937?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000644 https://doaj.org/article/e9212af43a7042f5a366fe26f3c59f22 PLoS Neglected Tropical Diseases, Vol 4, Iss 3, p e644 (2010) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2010 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000644 2022-12-31T08:58:02Z Deworming HIV-1 infected individuals may delay HIV-1 disease progression. It is important to determine the prevalence and correlates of HIV-1/helminth co-infection in helminth-endemic areas.HIV-1 infected individuals (CD4>250 cells/ul) were screened for helminth infection at ten sites in Kenya. Prevalence and correlates of helminth infection were determined. A subset of individuals with soil-transmitted helminth infection was re-evaluated 12 weeks following albendazole therapy.Of 1,541 HIV-1 seropositive individuals screened, 298 (19.3%) had detectable helminth infections. Among individuals with helminth infection, hookworm species were the most prevalent (56.3%), followed by Ascaris lumbricoides (17.1%), Trichuris trichiura (8.7%), Schistosoma mansoni (7.1%), and Strongyloides stercoralis (1.3%). Infection with multiple species occurred in 9.4% of infections. After CD4 count was controlled for, rural residence (RR 1.40, 95% CI: 1.08-1.81), having no education (RR 1.57, 95% CI: 1.07-2.30), and higher CD4 count (RR 1.36, 95% CI: 1.07-1.73) remained independently associated with risk of helminth infection. Twelve weeks following treatment with albendazole, 32% of helminth-infected individuals had detectable helminths on examination. Residence, education, and CD4 count were not associated with persistent helminth infection.Among HIV-1 seropositive adults with CD4 counts above 250 cells/mm(3) in Kenya, traditional risk factors for helminth infection, including rural residence and lack of education, were associated with co-infection, while lower CD4 counts were not. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 4 3 e644 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Judd L Walson Barclay T Stewart Laura Sangaré Loice W Mbogo Phelgona A Otieno Benjamin K S Piper Barbra A Richardson Grace John-Stewart Prevalence and correlates of helminth co-infection in Kenyan HIV-1 infected adults. |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Deworming HIV-1 infected individuals may delay HIV-1 disease progression. It is important to determine the prevalence and correlates of HIV-1/helminth co-infection in helminth-endemic areas.HIV-1 infected individuals (CD4>250 cells/ul) were screened for helminth infection at ten sites in Kenya. Prevalence and correlates of helminth infection were determined. A subset of individuals with soil-transmitted helminth infection was re-evaluated 12 weeks following albendazole therapy.Of 1,541 HIV-1 seropositive individuals screened, 298 (19.3%) had detectable helminth infections. Among individuals with helminth infection, hookworm species were the most prevalent (56.3%), followed by Ascaris lumbricoides (17.1%), Trichuris trichiura (8.7%), Schistosoma mansoni (7.1%), and Strongyloides stercoralis (1.3%). Infection with multiple species occurred in 9.4% of infections. After CD4 count was controlled for, rural residence (RR 1.40, 95% CI: 1.08-1.81), having no education (RR 1.57, 95% CI: 1.07-2.30), and higher CD4 count (RR 1.36, 95% CI: 1.07-1.73) remained independently associated with risk of helminth infection. Twelve weeks following treatment with albendazole, 32% of helminth-infected individuals had detectable helminths on examination. Residence, education, and CD4 count were not associated with persistent helminth infection.Among HIV-1 seropositive adults with CD4 counts above 250 cells/mm(3) in Kenya, traditional risk factors for helminth infection, including rural residence and lack of education, were associated with co-infection, while lower CD4 counts were not. |
format |
Article in Journal/Newspaper |
author |
Judd L Walson Barclay T Stewart Laura Sangaré Loice W Mbogo Phelgona A Otieno Benjamin K S Piper Barbra A Richardson Grace John-Stewart |
author_facet |
Judd L Walson Barclay T Stewart Laura Sangaré Loice W Mbogo Phelgona A Otieno Benjamin K S Piper Barbra A Richardson Grace John-Stewart |
author_sort |
Judd L Walson |
title |
Prevalence and correlates of helminth co-infection in Kenyan HIV-1 infected adults. |
title_short |
Prevalence and correlates of helminth co-infection in Kenyan HIV-1 infected adults. |
title_full |
Prevalence and correlates of helminth co-infection in Kenyan HIV-1 infected adults. |
title_fullStr |
Prevalence and correlates of helminth co-infection in Kenyan HIV-1 infected adults. |
title_full_unstemmed |
Prevalence and correlates of helminth co-infection in Kenyan HIV-1 infected adults. |
title_sort |
prevalence and correlates of helminth co-infection in kenyan hiv-1 infected adults. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2010 |
url |
https://doi.org/10.1371/journal.pntd.0000644 https://doaj.org/article/e9212af43a7042f5a366fe26f3c59f22 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 4, Iss 3, p e644 (2010) |
op_relation |
http://europepmc.org/articles/PMC2846937?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000644 https://doaj.org/article/e9212af43a7042f5a366fe26f3c59f22 |
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https://doi.org/10.1371/journal.pntd.0000644 |
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PLoS Neglected Tropical Diseases |
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