Review of pyronaridine anti-malarial properties and product characteristics
Abstract Pyronaridine was synthesized in 1970 at the Institute of Chinese Parasitic Disease and has been used in China for over 30 years for the treatment of malaria. Pyronaridine has high potency against Plasmodium falciparum , including chloroquine-resistant strains. Studies in various animal mode...
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ftdoajarticles:oai:doaj.org/article:e8f0fafc5209450f8248d7eb984813ff 2023-05-15T15:09:23+02:00 Review of pyronaridine anti-malarial properties and product characteristics Croft Simon L Duparc Stephan Arbe-Barnes Sarah J Craft J Shin Chang-Sik Fleckenstein Lawrence Borghini-Fuhrer Isabelle Rim Han-Jong 2012-08-01T00:00:00Z https://doi.org/10.1186/1475-2875-11-270 https://doaj.org/article/e8f0fafc5209450f8248d7eb984813ff EN eng BMC http://www.malariajournal.com/content/11/1/270 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-270 1475-2875 https://doaj.org/article/e8f0fafc5209450f8248d7eb984813ff Malaria Journal, Vol 11, Iss 1, p 270 (2012) Pyronaridine Plasmodium falciparum Plasmodium vivax Review Artemisinin containing compound Anti-malarial therapy Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2012 ftdoajarticles https://doi.org/10.1186/1475-2875-11-270 2022-12-30T22:44:05Z Abstract Pyronaridine was synthesized in 1970 at the Institute of Chinese Parasitic Disease and has been used in China for over 30 years for the treatment of malaria. Pyronaridine has high potency against Plasmodium falciparum , including chloroquine-resistant strains. Studies in various animal models have shown pyronaridine to be effective against strains resistant to other anti-malarials, including chloroquine. Resistance to pyronaridine appears to emerge slowly and is further retarded when pyronaridine is used in combination with other anti-malarials, in particular, artesunate. Pyronaridine toxicity is generally less than that of chloroquine, though evidence of embryotoxicity in rodents suggests use with caution in pregnancy. Clinical pharmacokinetic data for pyronaridine indicates an elimination T 1/2 of 13.2 and 9.6 days, respectively, in adults and children with acute uncomplicated falciparum and vivax malaria in artemisinin-combination therapy. Clinical data for mono or combined pyronaridine therapy show excellent anti-malarial effects against P. falciparum and studies of combination therapy also show promise against Plasmodium vivax . Pyronaridine has been developed as a fixed dose combination therapy, in a 3:1 ratio, with artesunate for the treatment of acute uncomplicated P. falciparum malaria and blood stage P. vivax malaria with the name of Pyramax® and has received Positive Opinion by European Medicines Agency under the Article 58 procedure. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 11 1 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
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English |
topic |
Pyronaridine Plasmodium falciparum Plasmodium vivax Review Artemisinin containing compound Anti-malarial therapy Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Pyronaridine Plasmodium falciparum Plasmodium vivax Review Artemisinin containing compound Anti-malarial therapy Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Croft Simon L Duparc Stephan Arbe-Barnes Sarah J Craft J Shin Chang-Sik Fleckenstein Lawrence Borghini-Fuhrer Isabelle Rim Han-Jong Review of pyronaridine anti-malarial properties and product characteristics |
topic_facet |
Pyronaridine Plasmodium falciparum Plasmodium vivax Review Artemisinin containing compound Anti-malarial therapy Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Pyronaridine was synthesized in 1970 at the Institute of Chinese Parasitic Disease and has been used in China for over 30 years for the treatment of malaria. Pyronaridine has high potency against Plasmodium falciparum , including chloroquine-resistant strains. Studies in various animal models have shown pyronaridine to be effective against strains resistant to other anti-malarials, including chloroquine. Resistance to pyronaridine appears to emerge slowly and is further retarded when pyronaridine is used in combination with other anti-malarials, in particular, artesunate. Pyronaridine toxicity is generally less than that of chloroquine, though evidence of embryotoxicity in rodents suggests use with caution in pregnancy. Clinical pharmacokinetic data for pyronaridine indicates an elimination T 1/2 of 13.2 and 9.6 days, respectively, in adults and children with acute uncomplicated falciparum and vivax malaria in artemisinin-combination therapy. Clinical data for mono or combined pyronaridine therapy show excellent anti-malarial effects against P. falciparum and studies of combination therapy also show promise against Plasmodium vivax . Pyronaridine has been developed as a fixed dose combination therapy, in a 3:1 ratio, with artesunate for the treatment of acute uncomplicated P. falciparum malaria and blood stage P. vivax malaria with the name of Pyramax® and has received Positive Opinion by European Medicines Agency under the Article 58 procedure. |
format |
Article in Journal/Newspaper |
author |
Croft Simon L Duparc Stephan Arbe-Barnes Sarah J Craft J Shin Chang-Sik Fleckenstein Lawrence Borghini-Fuhrer Isabelle Rim Han-Jong |
author_facet |
Croft Simon L Duparc Stephan Arbe-Barnes Sarah J Craft J Shin Chang-Sik Fleckenstein Lawrence Borghini-Fuhrer Isabelle Rim Han-Jong |
author_sort |
Croft Simon L |
title |
Review of pyronaridine anti-malarial properties and product characteristics |
title_short |
Review of pyronaridine anti-malarial properties and product characteristics |
title_full |
Review of pyronaridine anti-malarial properties and product characteristics |
title_fullStr |
Review of pyronaridine anti-malarial properties and product characteristics |
title_full_unstemmed |
Review of pyronaridine anti-malarial properties and product characteristics |
title_sort |
review of pyronaridine anti-malarial properties and product characteristics |
publisher |
BMC |
publishDate |
2012 |
url |
https://doi.org/10.1186/1475-2875-11-270 https://doaj.org/article/e8f0fafc5209450f8248d7eb984813ff |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 11, Iss 1, p 270 (2012) |
op_relation |
http://www.malariajournal.com/content/11/1/270 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-270 1475-2875 https://doaj.org/article/e8f0fafc5209450f8248d7eb984813ff |
op_doi |
https://doi.org/10.1186/1475-2875-11-270 |
container_title |
Malaria Journal |
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11 |
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1 |
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1766340596104953856 |