A fully liquid DTPw-HepB-Hib combination vaccine for booster vaccination of toddlers in El Salvador Vacuna líquida combinada DTPw-HepB-Hib como dosis de refuerzo en infantes de El Salvador
OBJECTIVES:To compare the safety and immunogenicity of a booster dose of a fully liquid diphtheria-tetanus-whole cell pertussis-hepatitis B-Haemophilus influenzae type b (DTPw-HepB-Hib) vaccine to the separate administration of commercially available DTPw and Hib vaccines in healthy toddlers. METHOD...
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Pan American Health Organization
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ftdoajarticles:oai:doaj.org/article:e8b0f31c38fa444ba43a9b67df78be6e 2023-05-15T15:18:52+02:00 A fully liquid DTPw-HepB-Hib combination vaccine for booster vaccination of toddlers in El Salvador Vacuna líquida combinada DTPw-HepB-Hib como dosis de refuerzo en infantes de El Salvador Eduardo Suárez Edwin J. Asturias Anne Katrin Hilbert Christian Herzog Ursula Aeberhard Christian Spyr 2010-02-01T00:00:00Z https://doaj.org/article/e8b0f31c38fa444ba43a9b67df78be6e EN ES PT eng spa por Pan American Health Organization http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892010000200005 https://doaj.org/toc/1020-4989 https://doaj.org/toc/1680-5348 1020-4989 1680-5348 https://doaj.org/article/e8b0f31c38fa444ba43a9b67df78be6e Revista Panamericana de Salud Pública, Vol 27, Iss 2, Pp 117-124 (2010) Vacunas esquema de inmunización vacunas contra la hepatitis B vacunas contra Haemophilus vacuna contra difteria tétanos y tos ferina lactante El Salvador Vaccines immunization methods Hepatitis B vaccines Haemophilus vaccines Diphtheria-Tetanus-Pertussis vaccine infant Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2010 ftdoajarticles 2022-12-31T02:52:25Z OBJECTIVES:To compare the safety and immunogenicity of a booster dose of a fully liquid diphtheria-tetanus-whole cell pertussis-hepatitis B-Haemophilus influenzae type b (DTPw-HepB-Hib) vaccine to the separate administration of commercially available DTPw and Hib vaccines in healthy toddlers. METHODS:An open-label, randomized, parallel-group, Phase III study conducted at six centers in San Salvador, El Salvador, during February-June 2006. Toddlers (15-24 months of age) were eligible to participate if they had received primary immunization at 2, 4, and 6 months of age with a commercial DTPw-HepB/Hib vaccine requiring reconstitution. Participants received either one booster dose of DTPw-HepB-Hib fully liquid vaccine or DTPw and Hib vaccines administered separately. Blood samples were taken immediately prior to and at 1 month post-vaccination. For a 5-day period following vaccination, solicited adverse events were collected in subject diaries and assessed. RESULTS:The combined DTPw-HepB-Hib fully liquid vaccine was non-inferior to the separately administered DTPw and Hib vaccines, in terms of seroprotection/seroconversion rates for all antigens evaluated. The combination vaccine elicited a strong booster response as demonstrated by a large increase in antibodies against all vaccine antigens. The geometric mean concentrations (GMCs) of all antibodies in the DTPw-HepB-Hib group exceeded the seroprotection/seroconversion thresholds by very large margins, although for some antigens they were somewhat lower than the corresponding titers in the comparator group. With the combination vaccine, considerably fewer solicited local and systemic adverse events, such as fever and irritability, were reported than with the comparator vaccines. CONCLUSIONS:This study demonstrates that the fully liquid combined DTPw-HepB-Hib vaccine is highly immunogenic and has a favorable safety profile when given as a booster vaccination to toddlers who have received a primary vaccination course with a different pentavalent vaccine that requires ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English Spanish Portuguese |
topic |
Vacunas esquema de inmunización vacunas contra la hepatitis B vacunas contra Haemophilus vacuna contra difteria tétanos y tos ferina lactante El Salvador Vaccines immunization methods Hepatitis B vaccines Haemophilus vaccines Diphtheria-Tetanus-Pertussis vaccine infant Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Vacunas esquema de inmunización vacunas contra la hepatitis B vacunas contra Haemophilus vacuna contra difteria tétanos y tos ferina lactante El Salvador Vaccines immunization methods Hepatitis B vaccines Haemophilus vaccines Diphtheria-Tetanus-Pertussis vaccine infant Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Eduardo Suárez Edwin J. Asturias Anne Katrin Hilbert Christian Herzog Ursula Aeberhard Christian Spyr A fully liquid DTPw-HepB-Hib combination vaccine for booster vaccination of toddlers in El Salvador Vacuna líquida combinada DTPw-HepB-Hib como dosis de refuerzo en infantes de El Salvador |
topic_facet |
Vacunas esquema de inmunización vacunas contra la hepatitis B vacunas contra Haemophilus vacuna contra difteria tétanos y tos ferina lactante El Salvador Vaccines immunization methods Hepatitis B vaccines Haemophilus vaccines Diphtheria-Tetanus-Pertussis vaccine infant Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
OBJECTIVES:To compare the safety and immunogenicity of a booster dose of a fully liquid diphtheria-tetanus-whole cell pertussis-hepatitis B-Haemophilus influenzae type b (DTPw-HepB-Hib) vaccine to the separate administration of commercially available DTPw and Hib vaccines in healthy toddlers. METHODS:An open-label, randomized, parallel-group, Phase III study conducted at six centers in San Salvador, El Salvador, during February-June 2006. Toddlers (15-24 months of age) were eligible to participate if they had received primary immunization at 2, 4, and 6 months of age with a commercial DTPw-HepB/Hib vaccine requiring reconstitution. Participants received either one booster dose of DTPw-HepB-Hib fully liquid vaccine or DTPw and Hib vaccines administered separately. Blood samples were taken immediately prior to and at 1 month post-vaccination. For a 5-day period following vaccination, solicited adverse events were collected in subject diaries and assessed. RESULTS:The combined DTPw-HepB-Hib fully liquid vaccine was non-inferior to the separately administered DTPw and Hib vaccines, in terms of seroprotection/seroconversion rates for all antigens evaluated. The combination vaccine elicited a strong booster response as demonstrated by a large increase in antibodies against all vaccine antigens. The geometric mean concentrations (GMCs) of all antibodies in the DTPw-HepB-Hib group exceeded the seroprotection/seroconversion thresholds by very large margins, although for some antigens they were somewhat lower than the corresponding titers in the comparator group. With the combination vaccine, considerably fewer solicited local and systemic adverse events, such as fever and irritability, were reported than with the comparator vaccines. CONCLUSIONS:This study demonstrates that the fully liquid combined DTPw-HepB-Hib vaccine is highly immunogenic and has a favorable safety profile when given as a booster vaccination to toddlers who have received a primary vaccination course with a different pentavalent vaccine that requires ... |
format |
Article in Journal/Newspaper |
author |
Eduardo Suárez Edwin J. Asturias Anne Katrin Hilbert Christian Herzog Ursula Aeberhard Christian Spyr |
author_facet |
Eduardo Suárez Edwin J. Asturias Anne Katrin Hilbert Christian Herzog Ursula Aeberhard Christian Spyr |
author_sort |
Eduardo Suárez |
title |
A fully liquid DTPw-HepB-Hib combination vaccine for booster vaccination of toddlers in El Salvador Vacuna líquida combinada DTPw-HepB-Hib como dosis de refuerzo en infantes de El Salvador |
title_short |
A fully liquid DTPw-HepB-Hib combination vaccine for booster vaccination of toddlers in El Salvador Vacuna líquida combinada DTPw-HepB-Hib como dosis de refuerzo en infantes de El Salvador |
title_full |
A fully liquid DTPw-HepB-Hib combination vaccine for booster vaccination of toddlers in El Salvador Vacuna líquida combinada DTPw-HepB-Hib como dosis de refuerzo en infantes de El Salvador |
title_fullStr |
A fully liquid DTPw-HepB-Hib combination vaccine for booster vaccination of toddlers in El Salvador Vacuna líquida combinada DTPw-HepB-Hib como dosis de refuerzo en infantes de El Salvador |
title_full_unstemmed |
A fully liquid DTPw-HepB-Hib combination vaccine for booster vaccination of toddlers in El Salvador Vacuna líquida combinada DTPw-HepB-Hib como dosis de refuerzo en infantes de El Salvador |
title_sort |
fully liquid dtpw-hepb-hib combination vaccine for booster vaccination of toddlers in el salvador vacuna líquida combinada dtpw-hepb-hib como dosis de refuerzo en infantes de el salvador |
publisher |
Pan American Health Organization |
publishDate |
2010 |
url |
https://doaj.org/article/e8b0f31c38fa444ba43a9b67df78be6e |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista Panamericana de Salud Pública, Vol 27, Iss 2, Pp 117-124 (2010) |
op_relation |
http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892010000200005 https://doaj.org/toc/1020-4989 https://doaj.org/toc/1680-5348 1020-4989 1680-5348 https://doaj.org/article/e8b0f31c38fa444ba43a9b67df78be6e |
_version_ |
1766349037660798976 |