Do antenatal parasite infections devalue childhood vaccination?
On a global basis, both potent vaccine efficacy and high vaccine coverage are necessary to control and eliminate vaccine-preventable diseases. Emerging evidence from animal and human studies suggest that neglected tropical diseases (NTDs) significantly impair response to standard childhood immunizat...
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ftdoajarticles:oai:doaj.org/article:e8a142a0775e46b59ebf28cc898029a6 2023-05-15T15:09:17+02:00 Do antenatal parasite infections devalue childhood vaccination? A Desiree Labeaud Indu Malhotra Maria J King Christopher L King Charles H King 2009-05-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000442 https://doaj.org/article/e8a142a0775e46b59ebf28cc898029a6 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC2682196?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000442 https://doaj.org/article/e8a142a0775e46b59ebf28cc898029a6 PLoS Neglected Tropical Diseases, Vol 3, Iss 5, p e442 (2009) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2009 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000442 2022-12-31T03:12:01Z On a global basis, both potent vaccine efficacy and high vaccine coverage are necessary to control and eliminate vaccine-preventable diseases. Emerging evidence from animal and human studies suggest that neglected tropical diseases (NTDs) significantly impair response to standard childhood immunizations. A review of efficacy and effectiveness studies of vaccination among individuals with chronic parasitic infections was conducted, using PUBMED database searches and analysis of data from the authors' published and unpublished studies. Both animal models and human studies suggest that chronic trematode, nematode, and protozoan infections can result in decreased vaccine efficacy. Among pregnant women, who in developing countries are often infected with multiple parasites, soluble parasite antigens have been shown to cross the placenta and prime or tolerize fetal immune responses. As a result, antenatal infections can have a significant impact on later vaccine responses. Acquired childhood parasitic infections, most commonly malaria, can also affect subsequent immune response to vaccination. Additional data suggest that antiparasite therapy can improve the effectiveness of several human vaccines. Emerging evidence demonstrates that both antenatal and childhood parasitic infections alter levels of protective immune response to routine vaccinations. Successful antiparasite treatment may prevent immunomodulation caused by parasitic antigens during pregnancy and early childhood and may improve vaccine efficacy. Future research should highlight the varied effects that different parasites (alone and in combination) can have on human vaccine-related immunity. To optimize vaccine effectiveness in developing countries, better control of chronic NTDs may prove imperative. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 3 5 e442 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 A Desiree Labeaud Indu Malhotra Maria J King Christopher L King Charles H King Do antenatal parasite infections devalue childhood vaccination? |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
On a global basis, both potent vaccine efficacy and high vaccine coverage are necessary to control and eliminate vaccine-preventable diseases. Emerging evidence from animal and human studies suggest that neglected tropical diseases (NTDs) significantly impair response to standard childhood immunizations. A review of efficacy and effectiveness studies of vaccination among individuals with chronic parasitic infections was conducted, using PUBMED database searches and analysis of data from the authors' published and unpublished studies. Both animal models and human studies suggest that chronic trematode, nematode, and protozoan infections can result in decreased vaccine efficacy. Among pregnant women, who in developing countries are often infected with multiple parasites, soluble parasite antigens have been shown to cross the placenta and prime or tolerize fetal immune responses. As a result, antenatal infections can have a significant impact on later vaccine responses. Acquired childhood parasitic infections, most commonly malaria, can also affect subsequent immune response to vaccination. Additional data suggest that antiparasite therapy can improve the effectiveness of several human vaccines. Emerging evidence demonstrates that both antenatal and childhood parasitic infections alter levels of protective immune response to routine vaccinations. Successful antiparasite treatment may prevent immunomodulation caused by parasitic antigens during pregnancy and early childhood and may improve vaccine efficacy. Future research should highlight the varied effects that different parasites (alone and in combination) can have on human vaccine-related immunity. To optimize vaccine effectiveness in developing countries, better control of chronic NTDs may prove imperative. |
format |
Article in Journal/Newspaper |
author |
A Desiree Labeaud Indu Malhotra Maria J King Christopher L King Charles H King |
author_facet |
A Desiree Labeaud Indu Malhotra Maria J King Christopher L King Charles H King |
author_sort |
A Desiree Labeaud |
title |
Do antenatal parasite infections devalue childhood vaccination? |
title_short |
Do antenatal parasite infections devalue childhood vaccination? |
title_full |
Do antenatal parasite infections devalue childhood vaccination? |
title_fullStr |
Do antenatal parasite infections devalue childhood vaccination? |
title_full_unstemmed |
Do antenatal parasite infections devalue childhood vaccination? |
title_sort |
do antenatal parasite infections devalue childhood vaccination? |
publisher |
Public Library of Science (PLoS) |
publishDate |
2009 |
url |
https://doi.org/10.1371/journal.pntd.0000442 https://doaj.org/article/e8a142a0775e46b59ebf28cc898029a6 |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 3, Iss 5, p e442 (2009) |
op_relation |
http://europepmc.org/articles/PMC2682196?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000442 https://doaj.org/article/e8a142a0775e46b59ebf28cc898029a6 |
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https://doi.org/10.1371/journal.pntd.0000442 |
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PLoS Neglected Tropical Diseases |
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3 |
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5 |
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e442 |
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