Questions over high frequency of mutant PfATP6 haplotypes in traveller isolates
Abstract A recent paper in Malaria Journal suggests that a high proportion of Plasmodium falciparum isolates found in travellers returning from a range of African countries carry the PfATP6 A623E S769N haplotype, and that this genotype is associated with artemether resistance. Such a finding would r...
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Online Access: | https://doi.org/10.1186/1475-2875-11-186 https://doaj.org/article/e870403b95584a36a121f8ff90546159 |
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ftdoajarticles:oai:doaj.org/article:e870403b95584a36a121f8ff90546159 2023-05-15T15:03:06+02:00 Questions over high frequency of mutant PfATP6 haplotypes in traveller isolates Woodrow Charles J Gardner Kate B Bustamante Leyla Y 2012-06-01T00:00:00Z https://doi.org/10.1186/1475-2875-11-186 https://doaj.org/article/e870403b95584a36a121f8ff90546159 EN eng BMC http://www.malariajournal.com/content/11/1/186 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-186 1475-2875 https://doaj.org/article/e870403b95584a36a121f8ff90546159 Malaria Journal, Vol 11, Iss 1, p 186 (2012) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2012 ftdoajarticles https://doi.org/10.1186/1475-2875-11-186 2022-12-31T04:56:44Z Abstract A recent paper in Malaria Journal suggests that a high proportion of Plasmodium falciparum isolates found in travellers returning from a range of African countries carry the PfATP6 A623E S769N haplotype, and that this genotype is associated with artemether resistance. Such a finding would represent a substantial departure from the extensive literature reporting these individual mutations to be very rare, with the double mutation never documented. The number of isolates screened to obtain these double mutants is unstated, but highly relevant, not least because selection of isolates could have introduced significant confounders, such as timing of in vitro testing. An additional concern relates to the location of sequencing primers used to assess these positions. In the absence of clear information on these fundamental questions it would be appropriate to treat the findings with caution. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Traveller ENVELOPE(-48.533,-48.533,61.133,61.133) Malaria Journal 11 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Woodrow Charles J Gardner Kate B Bustamante Leyla Y Questions over high frequency of mutant PfATP6 haplotypes in traveller isolates |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract A recent paper in Malaria Journal suggests that a high proportion of Plasmodium falciparum isolates found in travellers returning from a range of African countries carry the PfATP6 A623E S769N haplotype, and that this genotype is associated with artemether resistance. Such a finding would represent a substantial departure from the extensive literature reporting these individual mutations to be very rare, with the double mutation never documented. The number of isolates screened to obtain these double mutants is unstated, but highly relevant, not least because selection of isolates could have introduced significant confounders, such as timing of in vitro testing. An additional concern relates to the location of sequencing primers used to assess these positions. In the absence of clear information on these fundamental questions it would be appropriate to treat the findings with caution. |
format |
Article in Journal/Newspaper |
author |
Woodrow Charles J Gardner Kate B Bustamante Leyla Y |
author_facet |
Woodrow Charles J Gardner Kate B Bustamante Leyla Y |
author_sort |
Woodrow Charles J |
title |
Questions over high frequency of mutant PfATP6 haplotypes in traveller isolates |
title_short |
Questions over high frequency of mutant PfATP6 haplotypes in traveller isolates |
title_full |
Questions over high frequency of mutant PfATP6 haplotypes in traveller isolates |
title_fullStr |
Questions over high frequency of mutant PfATP6 haplotypes in traveller isolates |
title_full_unstemmed |
Questions over high frequency of mutant PfATP6 haplotypes in traveller isolates |
title_sort |
questions over high frequency of mutant pfatp6 haplotypes in traveller isolates |
publisher |
BMC |
publishDate |
2012 |
url |
https://doi.org/10.1186/1475-2875-11-186 https://doaj.org/article/e870403b95584a36a121f8ff90546159 |
long_lat |
ENVELOPE(-48.533,-48.533,61.133,61.133) |
geographic |
Arctic Traveller |
geographic_facet |
Arctic Traveller |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 11, Iss 1, p 186 (2012) |
op_relation |
http://www.malariajournal.com/content/11/1/186 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-186 1475-2875 https://doaj.org/article/e870403b95584a36a121f8ff90546159 |
op_doi |
https://doi.org/10.1186/1475-2875-11-186 |
container_title |
Malaria Journal |
container_volume |
11 |
container_issue |
1 |
_version_ |
1766335004245229568 |