A lethal model of Leptospira infection in hamster nasal mucosa.
Leptospirosis is a fatal zoonosis caused by contact between skin or a mucosal surface and contaminated soil or water. Hamsters were infected by intraperitoneal injection fto establish experimental leptospirosis, which is not a natural route of infection. There are no reports of nasal mucosal infecti...
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ftdoajarticles:oai:doaj.org/article:e8667a6c21a54b62a03c33eaa639dea8 2023-05-15T15:05:18+02:00 A lethal model of Leptospira infection in hamster nasal mucosa. Jiaqi Wang Wenlong Zhang Zhao Jin Yue Ding Shilei Zhang Dianjun Wu Yongguo Cao 2022-02-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0010191 https://doaj.org/article/e8667a6c21a54b62a03c33eaa639dea8 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0010191 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010191 https://doaj.org/article/e8667a6c21a54b62a03c33eaa639dea8 PLoS Neglected Tropical Diseases, Vol 16, Iss 2, p e0010191 (2022) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2022 ftdoajarticles https://doi.org/10.1371/journal.pntd.0010191 2022-12-31T15:49:17Z Leptospirosis is a fatal zoonosis caused by contact between skin or a mucosal surface and contaminated soil or water. Hamsters were infected by intraperitoneal injection fto establish experimental leptospirosis, which is not a natural route of infection. There are no reports of nasal mucosal infection in hamsters. In this study, infection of the nasal mucosa was performed to establish a model of natural infection. Both methods of infection can cause lethal models with similar symptoms in the later stages of infection, such as weight loss, blood concentration, increased neutrophils (GRAN), and decreased lymphocytes (LYM) in the blood, severe organ damage and liver function obstruction. The burden of Leptospira in the organs and blood was lower in the mucosal inoculation groups at 1 day after infection. However, mucosal infection induced a higher Leptospira burden in urine than intraperitoneal infection in the late stages of infection. After nasal mucosal infection, antibody levels were higher and lasted longer. These results indicated that the route of nasal mucosal infection is a good choice for studying leptospirosis in hamsters. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 16 2 e0010191 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Jiaqi Wang Wenlong Zhang Zhao Jin Yue Ding Shilei Zhang Dianjun Wu Yongguo Cao A lethal model of Leptospira infection in hamster nasal mucosa. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Leptospirosis is a fatal zoonosis caused by contact between skin or a mucosal surface and contaminated soil or water. Hamsters were infected by intraperitoneal injection fto establish experimental leptospirosis, which is not a natural route of infection. There are no reports of nasal mucosal infection in hamsters. In this study, infection of the nasal mucosa was performed to establish a model of natural infection. Both methods of infection can cause lethal models with similar symptoms in the later stages of infection, such as weight loss, blood concentration, increased neutrophils (GRAN), and decreased lymphocytes (LYM) in the blood, severe organ damage and liver function obstruction. The burden of Leptospira in the organs and blood was lower in the mucosal inoculation groups at 1 day after infection. However, mucosal infection induced a higher Leptospira burden in urine than intraperitoneal infection in the late stages of infection. After nasal mucosal infection, antibody levels were higher and lasted longer. These results indicated that the route of nasal mucosal infection is a good choice for studying leptospirosis in hamsters. |
format |
Article in Journal/Newspaper |
author |
Jiaqi Wang Wenlong Zhang Zhao Jin Yue Ding Shilei Zhang Dianjun Wu Yongguo Cao |
author_facet |
Jiaqi Wang Wenlong Zhang Zhao Jin Yue Ding Shilei Zhang Dianjun Wu Yongguo Cao |
author_sort |
Jiaqi Wang |
title |
A lethal model of Leptospira infection in hamster nasal mucosa. |
title_short |
A lethal model of Leptospira infection in hamster nasal mucosa. |
title_full |
A lethal model of Leptospira infection in hamster nasal mucosa. |
title_fullStr |
A lethal model of Leptospira infection in hamster nasal mucosa. |
title_full_unstemmed |
A lethal model of Leptospira infection in hamster nasal mucosa. |
title_sort |
lethal model of leptospira infection in hamster nasal mucosa. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2022 |
url |
https://doi.org/10.1371/journal.pntd.0010191 https://doaj.org/article/e8667a6c21a54b62a03c33eaa639dea8 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 16, Iss 2, p e0010191 (2022) |
op_relation |
https://doi.org/10.1371/journal.pntd.0010191 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010191 https://doaj.org/article/e8667a6c21a54b62a03c33eaa639dea8 |
op_doi |
https://doi.org/10.1371/journal.pntd.0010191 |
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PLOS Neglected Tropical Diseases |
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16 |
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2 |
container_start_page |
e0010191 |
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