Somatic Disease in Survivors of Childhood Malignant Bone Tumors in the Nordic Countries
Survivors of malignant bone tumors in childhood are at risk of long-term adverse health effects. We comprehensively reviewed cases of somatic diseases that required a hospital contact in survivors of osteosarcoma and Ewing sarcoma. In a population-based cohort study, 620 five-year survivors of osteo...
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2021
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ftdoajarticles:oai:doaj.org/article:e86651affed4481da01c288d714bbcff 2023-08-27T04:10:13+02:00 Somatic Disease in Survivors of Childhood Malignant Bone Tumors in the Nordic Countries Camilla Pedersen Catherine Rechnitzer Elisabeth Anne Wreford Andersen Line Kenborg Filippa Nyboe Norsker Andrea Bautz Thomas Baad-Hansen Laufey Tryggvadottir Laura-Maria Madanat-Harjuoja Anna Sällfors Holmqvist Lars Hjorth Henrik Hasle Jeanette Falck Winther on behalf of the ALiCCS Study Group 2021-09-01T00:00:00Z https://doi.org/10.3390/cancers13184505 https://doaj.org/article/e86651affed4481da01c288d714bbcff EN eng MDPI AG https://www.mdpi.com/2072-6694/13/18/4505 https://doaj.org/toc/2072-6694 doi:10.3390/cancers13184505 2072-6694 https://doaj.org/article/e86651affed4481da01c288d714bbcff Cancers, Vol 13, Iss 4505, p 4505 (2021) childhood malignant bone tumors survivorship late effects somatic disease cohort study Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 article 2021 ftdoajarticles https://doi.org/10.3390/cancers13184505 2023-08-06T00:45:25Z Survivors of malignant bone tumors in childhood are at risk of long-term adverse health effects. We comprehensively reviewed cases of somatic diseases that required a hospital contact in survivors of osteosarcoma and Ewing sarcoma. In a population-based cohort study, 620 five-year survivors of osteosarcoma (n = 440) or Ewing sarcoma (n = 180), diagnosed before the age of 20 years in Denmark, Finland, Iceland, and Sweden during 1943–2008, were followed in the national hospital registers. Overall rates of hospital contacts for any somatic disease and for 12 main diagnostic groups and 120 specific disease categories were compared with those in a matched comparison cohort (n = 3049) randomly selected from the national population registers. The rate of hospital contact for any somatic disease was 80% higher in survivors of malignant bone tumors than in comparisons and remained elevated up to 30 years after diagnosis. The rate of hospital contacts was higher after Ewing sarcoma (rate ratio (RR) 2.24; 95% confidence interval (CI) 1.76–2.85) than after osteosarcoma (RR 1.67; 95% CI 1.41–1.98). Elevated rates were observed for 11 main diagnostic groups, including infections, second malignant neoplasms, and diseases of the skin, bones, and circulatory, digestive, endocrine, and urinary systems. Survivors of malignant bone tumors in childhood are at increased risk of somatic diseases many years after diagnosis. This comprehensive study contributes new insight into the risk of late effects in survivors of osteosarcoma and Ewing sarcoma, which is an essential basis for optimal patient counseling and follow-up care. Article in Journal/Newspaper Iceland Directory of Open Access Journals: DOAJ Articles Ewing ENVELOPE(-61.257,-61.257,-69.924,-69.924) Cancers 13 18 4505 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
childhood malignant bone tumors survivorship late effects somatic disease cohort study Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
spellingShingle |
childhood malignant bone tumors survivorship late effects somatic disease cohort study Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Camilla Pedersen Catherine Rechnitzer Elisabeth Anne Wreford Andersen Line Kenborg Filippa Nyboe Norsker Andrea Bautz Thomas Baad-Hansen Laufey Tryggvadottir Laura-Maria Madanat-Harjuoja Anna Sällfors Holmqvist Lars Hjorth Henrik Hasle Jeanette Falck Winther on behalf of the ALiCCS Study Group Somatic Disease in Survivors of Childhood Malignant Bone Tumors in the Nordic Countries |
topic_facet |
childhood malignant bone tumors survivorship late effects somatic disease cohort study Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
description |
Survivors of malignant bone tumors in childhood are at risk of long-term adverse health effects. We comprehensively reviewed cases of somatic diseases that required a hospital contact in survivors of osteosarcoma and Ewing sarcoma. In a population-based cohort study, 620 five-year survivors of osteosarcoma (n = 440) or Ewing sarcoma (n = 180), diagnosed before the age of 20 years in Denmark, Finland, Iceland, and Sweden during 1943–2008, were followed in the national hospital registers. Overall rates of hospital contacts for any somatic disease and for 12 main diagnostic groups and 120 specific disease categories were compared with those in a matched comparison cohort (n = 3049) randomly selected from the national population registers. The rate of hospital contact for any somatic disease was 80% higher in survivors of malignant bone tumors than in comparisons and remained elevated up to 30 years after diagnosis. The rate of hospital contacts was higher after Ewing sarcoma (rate ratio (RR) 2.24; 95% confidence interval (CI) 1.76–2.85) than after osteosarcoma (RR 1.67; 95% CI 1.41–1.98). Elevated rates were observed for 11 main diagnostic groups, including infections, second malignant neoplasms, and diseases of the skin, bones, and circulatory, digestive, endocrine, and urinary systems. Survivors of malignant bone tumors in childhood are at increased risk of somatic diseases many years after diagnosis. This comprehensive study contributes new insight into the risk of late effects in survivors of osteosarcoma and Ewing sarcoma, which is an essential basis for optimal patient counseling and follow-up care. |
format |
Article in Journal/Newspaper |
author |
Camilla Pedersen Catherine Rechnitzer Elisabeth Anne Wreford Andersen Line Kenborg Filippa Nyboe Norsker Andrea Bautz Thomas Baad-Hansen Laufey Tryggvadottir Laura-Maria Madanat-Harjuoja Anna Sällfors Holmqvist Lars Hjorth Henrik Hasle Jeanette Falck Winther on behalf of the ALiCCS Study Group |
author_facet |
Camilla Pedersen Catherine Rechnitzer Elisabeth Anne Wreford Andersen Line Kenborg Filippa Nyboe Norsker Andrea Bautz Thomas Baad-Hansen Laufey Tryggvadottir Laura-Maria Madanat-Harjuoja Anna Sällfors Holmqvist Lars Hjorth Henrik Hasle Jeanette Falck Winther on behalf of the ALiCCS Study Group |
author_sort |
Camilla Pedersen |
title |
Somatic Disease in Survivors of Childhood Malignant Bone Tumors in the Nordic Countries |
title_short |
Somatic Disease in Survivors of Childhood Malignant Bone Tumors in the Nordic Countries |
title_full |
Somatic Disease in Survivors of Childhood Malignant Bone Tumors in the Nordic Countries |
title_fullStr |
Somatic Disease in Survivors of Childhood Malignant Bone Tumors in the Nordic Countries |
title_full_unstemmed |
Somatic Disease in Survivors of Childhood Malignant Bone Tumors in the Nordic Countries |
title_sort |
somatic disease in survivors of childhood malignant bone tumors in the nordic countries |
publisher |
MDPI AG |
publishDate |
2021 |
url |
https://doi.org/10.3390/cancers13184505 https://doaj.org/article/e86651affed4481da01c288d714bbcff |
long_lat |
ENVELOPE(-61.257,-61.257,-69.924,-69.924) |
geographic |
Ewing |
geographic_facet |
Ewing |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Cancers, Vol 13, Iss 4505, p 4505 (2021) |
op_relation |
https://www.mdpi.com/2072-6694/13/18/4505 https://doaj.org/toc/2072-6694 doi:10.3390/cancers13184505 2072-6694 https://doaj.org/article/e86651affed4481da01c288d714bbcff |
op_doi |
https://doi.org/10.3390/cancers13184505 |
container_title |
Cancers |
container_volume |
13 |
container_issue |
18 |
container_start_page |
4505 |
_version_ |
1775352095713525760 |