Rosmarinic acid improves tracheal smooth muscle responsiveness and lung pathological changes in ovalbumin-sensitized rats
Objective: To evaluate the effect of rosmarinic acid on tracheal smooth muscle responsiveness and lung pathological changes in ovalbumin-sensitized rats. Methods: Rats were randomly divided into six groups: the control group, the asthmatic group, and the asthmatic groups treated with dexamethasone (...
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Wolters Kluwer Medknow Publications
2024
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ftdoajarticles:oai:doaj.org/article:e856bf177a5c49ce9937b00738da5131 2024-09-09T19:25:53+00:00 Rosmarinic acid improves tracheal smooth muscle responsiveness and lung pathological changes in ovalbumin-sensitized rats Vahideh Abbasnia Mohsen Foadoddini Delaram Eslimi Esfahani Mohammad Reza Khazdair Shahrbanoo Oryan 2024-01-01T00:00:00Z https://doi.org/10.4103/apjtb.apjtb_879_23 https://doaj.org/article/e856bf177a5c49ce9937b00738da5131 EN eng Wolters Kluwer Medknow Publications http://www.apjtb.org/article.asp?issn=2221-1691;year=2024;volume=14;issue=3;spage=100;epage=105;aulast=Abbasnia https://doaj.org/toc/2221-1691 https://doaj.org/toc/2588-9222 2221-1691 2588-9222 doi:10.4103/apjtb.apjtb_879_23 https://doaj.org/article/e856bf177a5c49ce9937b00738da5131 Asian Pacific Journal of Tropical Biomedicine, Vol 14, Iss 3, Pp 100-105 (2024) rosmarinic acid asthma ovalbumin tracheal responsiveness inflammation white blood cell Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2024 ftdoajarticles https://doi.org/10.4103/apjtb.apjtb_879_23 2024-08-05T17:49:31Z Objective: To evaluate the effect of rosmarinic acid on tracheal smooth muscle responsiveness and lung pathological changes in ovalbumin-sensitized rats. Methods: Rats were randomly divided into six groups: the control group, the asthmatic group, and the asthmatic groups treated with dexamethasone (1 mg/kg; oral gavage) or three doses of rosmarinic acid (0.5, 1, and 2 mg/kg; oral gavage). For induction of asthma, rats received intraperitoneal injections and inhalation of ovalbumin. After 21 days, bronchoalveolar lavage fluid and lung samples were collected for histopathological analyses. Moreover, total and differential white blood cell counts were determined. Results: The rosmarinic acid-treated group had significantly lower tracheal smooth muscle responses to methacholine than the asthmatic group. In addition, rosmarinic acid reduced white blood cell count and the percentages of eosinophils, monocytes, and neutrophils while increasing the percentage of lymphocytes. Ovalbumin-induced lung pathological changes were significantly improved by treatment with rosmarinic acid. Conclusions: Rosmarinic acid improves tracheal smooth muscle responsiveness and lung pathological changes in ovalbumin-sensitized rats. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 14 3 100 105 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
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English |
topic |
rosmarinic acid asthma ovalbumin tracheal responsiveness inflammation white blood cell Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
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rosmarinic acid asthma ovalbumin tracheal responsiveness inflammation white blood cell Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Vahideh Abbasnia Mohsen Foadoddini Delaram Eslimi Esfahani Mohammad Reza Khazdair Shahrbanoo Oryan Rosmarinic acid improves tracheal smooth muscle responsiveness and lung pathological changes in ovalbumin-sensitized rats |
topic_facet |
rosmarinic acid asthma ovalbumin tracheal responsiveness inflammation white blood cell Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To evaluate the effect of rosmarinic acid on tracheal smooth muscle responsiveness and lung pathological changes in ovalbumin-sensitized rats. Methods: Rats were randomly divided into six groups: the control group, the asthmatic group, and the asthmatic groups treated with dexamethasone (1 mg/kg; oral gavage) or three doses of rosmarinic acid (0.5, 1, and 2 mg/kg; oral gavage). For induction of asthma, rats received intraperitoneal injections and inhalation of ovalbumin. After 21 days, bronchoalveolar lavage fluid and lung samples were collected for histopathological analyses. Moreover, total and differential white blood cell counts were determined. Results: The rosmarinic acid-treated group had significantly lower tracheal smooth muscle responses to methacholine than the asthmatic group. In addition, rosmarinic acid reduced white blood cell count and the percentages of eosinophils, monocytes, and neutrophils while increasing the percentage of lymphocytes. Ovalbumin-induced lung pathological changes were significantly improved by treatment with rosmarinic acid. Conclusions: Rosmarinic acid improves tracheal smooth muscle responsiveness and lung pathological changes in ovalbumin-sensitized rats. |
format |
Article in Journal/Newspaper |
author |
Vahideh Abbasnia Mohsen Foadoddini Delaram Eslimi Esfahani Mohammad Reza Khazdair Shahrbanoo Oryan |
author_facet |
Vahideh Abbasnia Mohsen Foadoddini Delaram Eslimi Esfahani Mohammad Reza Khazdair Shahrbanoo Oryan |
author_sort |
Vahideh Abbasnia |
title |
Rosmarinic acid improves tracheal smooth muscle responsiveness and lung pathological changes in ovalbumin-sensitized rats |
title_short |
Rosmarinic acid improves tracheal smooth muscle responsiveness and lung pathological changes in ovalbumin-sensitized rats |
title_full |
Rosmarinic acid improves tracheal smooth muscle responsiveness and lung pathological changes in ovalbumin-sensitized rats |
title_fullStr |
Rosmarinic acid improves tracheal smooth muscle responsiveness and lung pathological changes in ovalbumin-sensitized rats |
title_full_unstemmed |
Rosmarinic acid improves tracheal smooth muscle responsiveness and lung pathological changes in ovalbumin-sensitized rats |
title_sort |
rosmarinic acid improves tracheal smooth muscle responsiveness and lung pathological changes in ovalbumin-sensitized rats |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2024 |
url |
https://doi.org/10.4103/apjtb.apjtb_879_23 https://doaj.org/article/e856bf177a5c49ce9937b00738da5131 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 14, Iss 3, Pp 100-105 (2024) |
op_relation |
http://www.apjtb.org/article.asp?issn=2221-1691;year=2024;volume=14;issue=3;spage=100;epage=105;aulast=Abbasnia https://doaj.org/toc/2221-1691 https://doaj.org/toc/2588-9222 2221-1691 2588-9222 doi:10.4103/apjtb.apjtb_879_23 https://doaj.org/article/e856bf177a5c49ce9937b00738da5131 |
op_doi |
https://doi.org/10.4103/apjtb.apjtb_879_23 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
14 |
container_issue |
3 |
container_start_page |
100 |
op_container_end_page |
105 |
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1809895594869653504 |