Anti-tumor effects and cellular mechanisms of Pistacia atlantica methanolic extract against Ehrlich solid tumor in mice
Objective: To assess the anti-tumor effects of Pistacia atlantica methanolic extract (PAME) compared with cyclophosphamide against Ehrlich solid tumors in mice. Methods: Swiss albino mice (n=40) were divided into five groups: normal control mice, mice with Ehrlich solid tumors treated with normal sa...
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Wolters Kluwer Medknow Publications
2022
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ftdoajarticles:oai:doaj.org/article:e82bf751c3574d929c5db47c01b6a9e8 2023-05-15T15:09:17+02:00 Anti-tumor effects and cellular mechanisms of Pistacia atlantica methanolic extract against Ehrlich solid tumor in mice Aishah E Albalawi Norah A Althobaiti Reem Hasaballah Alhasani Sultan F Alnomasy 2022-01-01T00:00:00Z https://doi.org/10.4103/2221-1691.335695 https://doaj.org/article/e82bf751c3574d929c5db47c01b6a9e8 EN eng Wolters Kluwer Medknow Publications http://www.apjtb.org/article.asp?issn=2221-1691;year=2022;volume=12;issue=2;spage=69;epage=77;aulast=Albalawi https://doaj.org/toc/2221-1691 https://doaj.org/toc/2588-9222 2221-1691 2588-9222 doi:10.4103/2221-1691.335695 https://doaj.org/article/e82bf751c3574d929c5db47c01b6a9e8 Asian Pacific Journal of Tropical Biomedicine, Vol 12, Iss 2, Pp 69-77 (2022) cancer ehrlich solid tumors treatment pistacia atlantica herbal medicines natural product in vivo mice Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2022 ftdoajarticles https://doi.org/10.4103/2221-1691.335695 2022-12-31T09:42:49Z Objective: To assess the anti-tumor effects of Pistacia atlantica methanolic extract (PAME) compared with cyclophosphamide against Ehrlich solid tumors in mice. Methods: Swiss albino mice (n=40) were divided into five groups: normal control mice, mice with Ehrlich solid tumors treated with normal saline, mice with Ehrlich solid tumors treated with cyclophosphamide intraperitoneally once a day for 14 d, or 50 mg/kg or 100 mg/kg PAME orally once a day for 14 d. Tumor growth inhibition, body weight, tumor markers, liver and kidney enzymes, oxidative stress markers, antioxidant enzymes, tumor necrosis factor-alpha level (TNF-α), and apoptosis-regulatory gene expression were evaluated. Results: Treatment of mice bearing Ehrlich solid tumors with PAME at 50 and 100 mg/kg orally significantly decreased tumor volume, body weight, tumor markers, liver and kidney enzymes, oxidative stress markers and TNF-α level in comparison with mice with Ehrlich solid tumors receiving normal saline. whereas PAME at 50 and 100 mg/kg/day significantly elevated the level of antioxidant enzymes (P<0.05). Conclusions: Pistacia atlantica methanolic extract has potent antitumor activity in mice. Therefore, the extract might be considered as an alternative anticancer agent against tumors, however, additional studies especially in the clinical setting are required to confirm this finding. Article in Journal/Newspaper Arctic PAME Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 12 2 69 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
cancer ehrlich solid tumors treatment pistacia atlantica herbal medicines natural product in vivo mice Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
cancer ehrlich solid tumors treatment pistacia atlantica herbal medicines natural product in vivo mice Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Aishah E Albalawi Norah A Althobaiti Reem Hasaballah Alhasani Sultan F Alnomasy Anti-tumor effects and cellular mechanisms of Pistacia atlantica methanolic extract against Ehrlich solid tumor in mice |
topic_facet |
cancer ehrlich solid tumors treatment pistacia atlantica herbal medicines natural product in vivo mice Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To assess the anti-tumor effects of Pistacia atlantica methanolic extract (PAME) compared with cyclophosphamide against Ehrlich solid tumors in mice. Methods: Swiss albino mice (n=40) were divided into five groups: normal control mice, mice with Ehrlich solid tumors treated with normal saline, mice with Ehrlich solid tumors treated with cyclophosphamide intraperitoneally once a day for 14 d, or 50 mg/kg or 100 mg/kg PAME orally once a day for 14 d. Tumor growth inhibition, body weight, tumor markers, liver and kidney enzymes, oxidative stress markers, antioxidant enzymes, tumor necrosis factor-alpha level (TNF-α), and apoptosis-regulatory gene expression were evaluated. Results: Treatment of mice bearing Ehrlich solid tumors with PAME at 50 and 100 mg/kg orally significantly decreased tumor volume, body weight, tumor markers, liver and kidney enzymes, oxidative stress markers and TNF-α level in comparison with mice with Ehrlich solid tumors receiving normal saline. whereas PAME at 50 and 100 mg/kg/day significantly elevated the level of antioxidant enzymes (P<0.05). Conclusions: Pistacia atlantica methanolic extract has potent antitumor activity in mice. Therefore, the extract might be considered as an alternative anticancer agent against tumors, however, additional studies especially in the clinical setting are required to confirm this finding. |
format |
Article in Journal/Newspaper |
author |
Aishah E Albalawi Norah A Althobaiti Reem Hasaballah Alhasani Sultan F Alnomasy |
author_facet |
Aishah E Albalawi Norah A Althobaiti Reem Hasaballah Alhasani Sultan F Alnomasy |
author_sort |
Aishah E Albalawi |
title |
Anti-tumor effects and cellular mechanisms of Pistacia atlantica methanolic extract against Ehrlich solid tumor in mice |
title_short |
Anti-tumor effects and cellular mechanisms of Pistacia atlantica methanolic extract against Ehrlich solid tumor in mice |
title_full |
Anti-tumor effects and cellular mechanisms of Pistacia atlantica methanolic extract against Ehrlich solid tumor in mice |
title_fullStr |
Anti-tumor effects and cellular mechanisms of Pistacia atlantica methanolic extract against Ehrlich solid tumor in mice |
title_full_unstemmed |
Anti-tumor effects and cellular mechanisms of Pistacia atlantica methanolic extract against Ehrlich solid tumor in mice |
title_sort |
anti-tumor effects and cellular mechanisms of pistacia atlantica methanolic extract against ehrlich solid tumor in mice |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2022 |
url |
https://doi.org/10.4103/2221-1691.335695 https://doaj.org/article/e82bf751c3574d929c5db47c01b6a9e8 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic PAME |
genre_facet |
Arctic PAME |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 12, Iss 2, Pp 69-77 (2022) |
op_relation |
http://www.apjtb.org/article.asp?issn=2221-1691;year=2022;volume=12;issue=2;spage=69;epage=77;aulast=Albalawi https://doaj.org/toc/2221-1691 https://doaj.org/toc/2588-9222 2221-1691 2588-9222 doi:10.4103/2221-1691.335695 https://doaj.org/article/e82bf751c3574d929c5db47c01b6a9e8 |
op_doi |
https://doi.org/10.4103/2221-1691.335695 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
12 |
container_issue |
2 |
container_start_page |
69 |
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1766340497272471552 |