Unique hemoglobin dynamics in female Tibetan highlanders
Abstract Background Tibetan highlanders have adapted to hypoxic environments through the development of unique mechanisms that suppress an increase in hemoglobin (Hb) concentration even in high-altitude areas. Hb concentrations generally decrease with increasing age. However, in the highlands, chron...
Published in: | Tropical Medicine and Health |
---|---|
Main Authors: | , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
BMC
2021
|
Subjects: | |
Online Access: | https://doi.org/10.1186/s41182-020-00289-6 https://doaj.org/article/e8299a7482e04df1a0e79a4331a33b07 |
id |
ftdoajarticles:oai:doaj.org/article:e8299a7482e04df1a0e79a4331a33b07 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:e8299a7482e04df1a0e79a4331a33b07 2023-05-15T15:04:36+02:00 Unique hemoglobin dynamics in female Tibetan highlanders Hiroaki Arima Masayuki Nakano Sweta Koirala Hiromu Ito Basu Dev Pandey Kishor Pandey Takayuki Wada Taro Yamamoto 2021-01-01T00:00:00Z https://doi.org/10.1186/s41182-020-00289-6 https://doaj.org/article/e8299a7482e04df1a0e79a4331a33b07 EN eng BMC https://doi.org/10.1186/s41182-020-00289-6 https://doaj.org/toc/1349-4147 doi:10.1186/s41182-020-00289-6 1349-4147 https://doaj.org/article/e8299a7482e04df1a0e79a4331a33b07 Tropical Medicine and Health, Vol 49, Iss 1, Pp 1-10 (2021) Arctic medicine. Tropical medicine RC955-962 article 2021 ftdoajarticles https://doi.org/10.1186/s41182-020-00289-6 2022-12-31T05:24:05Z Abstract Background Tibetan highlanders have adapted to hypoxic environments through the development of unique mechanisms that suppress an increase in hemoglobin (Hb) concentration even in high-altitude areas. Hb concentrations generally decrease with increasing age. However, in the highlands, chronic altitude sickness is known to occur in the elderly population. To investigate how aging in a hypoxic environment affects Hb levels in Tibetan highlanders, we focused on the Mustang people, who live above 3500 m. We tried to clarify the pure relationship between aging and Hb levels in a hypoxic environment. Results We found that the Hb concentration increased with increasing age in females but not in males. Multivariate analysis showed that age, pulse pressure, the poverty index, and vascular diameter were strongly correlated with the Hb concentration. Conclusions We found unique Hb dynamics among female Tibetan highlanders. As seen in these Hb dynamics, there may be sex-based differences in the adaptive mechanism in Tibetan highlanders. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Tropical Medicine and Health 49 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Hiroaki Arima Masayuki Nakano Sweta Koirala Hiromu Ito Basu Dev Pandey Kishor Pandey Takayuki Wada Taro Yamamoto Unique hemoglobin dynamics in female Tibetan highlanders |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract Background Tibetan highlanders have adapted to hypoxic environments through the development of unique mechanisms that suppress an increase in hemoglobin (Hb) concentration even in high-altitude areas. Hb concentrations generally decrease with increasing age. However, in the highlands, chronic altitude sickness is known to occur in the elderly population. To investigate how aging in a hypoxic environment affects Hb levels in Tibetan highlanders, we focused on the Mustang people, who live above 3500 m. We tried to clarify the pure relationship between aging and Hb levels in a hypoxic environment. Results We found that the Hb concentration increased with increasing age in females but not in males. Multivariate analysis showed that age, pulse pressure, the poverty index, and vascular diameter were strongly correlated with the Hb concentration. Conclusions We found unique Hb dynamics among female Tibetan highlanders. As seen in these Hb dynamics, there may be sex-based differences in the adaptive mechanism in Tibetan highlanders. |
format |
Article in Journal/Newspaper |
author |
Hiroaki Arima Masayuki Nakano Sweta Koirala Hiromu Ito Basu Dev Pandey Kishor Pandey Takayuki Wada Taro Yamamoto |
author_facet |
Hiroaki Arima Masayuki Nakano Sweta Koirala Hiromu Ito Basu Dev Pandey Kishor Pandey Takayuki Wada Taro Yamamoto |
author_sort |
Hiroaki Arima |
title |
Unique hemoglobin dynamics in female Tibetan highlanders |
title_short |
Unique hemoglobin dynamics in female Tibetan highlanders |
title_full |
Unique hemoglobin dynamics in female Tibetan highlanders |
title_fullStr |
Unique hemoglobin dynamics in female Tibetan highlanders |
title_full_unstemmed |
Unique hemoglobin dynamics in female Tibetan highlanders |
title_sort |
unique hemoglobin dynamics in female tibetan highlanders |
publisher |
BMC |
publishDate |
2021 |
url |
https://doi.org/10.1186/s41182-020-00289-6 https://doaj.org/article/e8299a7482e04df1a0e79a4331a33b07 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Tropical Medicine and Health, Vol 49, Iss 1, Pp 1-10 (2021) |
op_relation |
https://doi.org/10.1186/s41182-020-00289-6 https://doaj.org/toc/1349-4147 doi:10.1186/s41182-020-00289-6 1349-4147 https://doaj.org/article/e8299a7482e04df1a0e79a4331a33b07 |
op_doi |
https://doi.org/10.1186/s41182-020-00289-6 |
container_title |
Tropical Medicine and Health |
container_volume |
49 |
container_issue |
1 |
_version_ |
1766336341965012992 |