Severe falciparum malaria in young children of the Kassena-Nankana district of northern Ghana
Abstract Study design Severe falciparum malaria in children was studied as part of the characterization of the Kassena-Nankana District Ghana for future malaria vaccine trials. Children aged 6–59 months with diagnosis suggestive of acute disease were characterized using the standard WHO definition f...
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ftdoajarticles:oai:doaj.org/article:e7fa023ac17e454ebeaaede5e98b6df5 2023-05-15T15:09:50+02:00 Severe falciparum malaria in young children of the Kassena-Nankana district of northern Ghana Anto Francis Ansah Akosua Anyorigiya Thomas Ansah Patrick Atuguba Frank Rogers William Koram Kwadwo A Oduro Abraham R Mensah Nathan Hodgson Abraham Nkrumah Francis 2007-07-01T00:00:00Z https://doi.org/10.1186/1475-2875-6-96 https://doaj.org/article/e7fa023ac17e454ebeaaede5e98b6df5 EN eng BMC http://www.malariajournal.com/content/6/1/96 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-6-96 1475-2875 https://doaj.org/article/e7fa023ac17e454ebeaaede5e98b6df5 Malaria Journal, Vol 6, Iss 1, p 96 (2007) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2007 ftdoajarticles https://doi.org/10.1186/1475-2875-6-96 2022-12-31T07:08:42Z Abstract Study design Severe falciparum malaria in children was studied as part of the characterization of the Kassena-Nankana District Ghana for future malaria vaccine trials. Children aged 6–59 months with diagnosis suggestive of acute disease were characterized using the standard WHO definition for severe malaria. Results Of the total children screened, 45.2% (868/1921) satisfied the criteria for severe malaria. Estimated incidence of severe malaria was 3.4% (range: 0.4–8.3%) cases per year. The disease incidence was seasonal: 560 cases per year, of which 70.4% occurred during the wet season (June-October). The main manifestations were severe anaemia (36.5%); prolonged or multiple convulsions (21.6%); respiratory distress (24.4%) and cerebral malaria (5.4%). Others were hyperpyrexia (11.1%); hyperparasitaemia (18.5%); hyperlactaemia (33.4%); and hypoglycaemia (3.2%). The frequency of severe anaemia was 39.8% in children of six to 24 months of age and 25.9% in children of 25–60 months of age. More children (8.7%) in the 25–60 months age group had cerebral malaria compared with 4.4% in the 6–24 months age group. The overall case fatality ratio was 3.5%. Cerebral malaria and hyperlactataemia were the significant risk factors associated with death. Severe anaemia, though a major presentation, was not significantly associated with risk of death. Conclusion Severe malaria is a frequent and seasonal childhood disease in northern Ghana and maybe an adequate endpoint for future malaria vaccine trials. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 6 1 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Anto Francis Ansah Akosua Anyorigiya Thomas Ansah Patrick Atuguba Frank Rogers William Koram Kwadwo A Oduro Abraham R Mensah Nathan Hodgson Abraham Nkrumah Francis Severe falciparum malaria in young children of the Kassena-Nankana district of northern Ghana |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Study design Severe falciparum malaria in children was studied as part of the characterization of the Kassena-Nankana District Ghana for future malaria vaccine trials. Children aged 6–59 months with diagnosis suggestive of acute disease were characterized using the standard WHO definition for severe malaria. Results Of the total children screened, 45.2% (868/1921) satisfied the criteria for severe malaria. Estimated incidence of severe malaria was 3.4% (range: 0.4–8.3%) cases per year. The disease incidence was seasonal: 560 cases per year, of which 70.4% occurred during the wet season (June-October). The main manifestations were severe anaemia (36.5%); prolonged or multiple convulsions (21.6%); respiratory distress (24.4%) and cerebral malaria (5.4%). Others were hyperpyrexia (11.1%); hyperparasitaemia (18.5%); hyperlactaemia (33.4%); and hypoglycaemia (3.2%). The frequency of severe anaemia was 39.8% in children of six to 24 months of age and 25.9% in children of 25–60 months of age. More children (8.7%) in the 25–60 months age group had cerebral malaria compared with 4.4% in the 6–24 months age group. The overall case fatality ratio was 3.5%. Cerebral malaria and hyperlactataemia were the significant risk factors associated with death. Severe anaemia, though a major presentation, was not significantly associated with risk of death. Conclusion Severe malaria is a frequent and seasonal childhood disease in northern Ghana and maybe an adequate endpoint for future malaria vaccine trials. |
format |
Article in Journal/Newspaper |
author |
Anto Francis Ansah Akosua Anyorigiya Thomas Ansah Patrick Atuguba Frank Rogers William Koram Kwadwo A Oduro Abraham R Mensah Nathan Hodgson Abraham Nkrumah Francis |
author_facet |
Anto Francis Ansah Akosua Anyorigiya Thomas Ansah Patrick Atuguba Frank Rogers William Koram Kwadwo A Oduro Abraham R Mensah Nathan Hodgson Abraham Nkrumah Francis |
author_sort |
Anto Francis |
title |
Severe falciparum malaria in young children of the Kassena-Nankana district of northern Ghana |
title_short |
Severe falciparum malaria in young children of the Kassena-Nankana district of northern Ghana |
title_full |
Severe falciparum malaria in young children of the Kassena-Nankana district of northern Ghana |
title_fullStr |
Severe falciparum malaria in young children of the Kassena-Nankana district of northern Ghana |
title_full_unstemmed |
Severe falciparum malaria in young children of the Kassena-Nankana district of northern Ghana |
title_sort |
severe falciparum malaria in young children of the kassena-nankana district of northern ghana |
publisher |
BMC |
publishDate |
2007 |
url |
https://doi.org/10.1186/1475-2875-6-96 https://doaj.org/article/e7fa023ac17e454ebeaaede5e98b6df5 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 6, Iss 1, p 96 (2007) |
op_relation |
http://www.malariajournal.com/content/6/1/96 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-6-96 1475-2875 https://doaj.org/article/e7fa023ac17e454ebeaaede5e98b6df5 |
op_doi |
https://doi.org/10.1186/1475-2875-6-96 |
container_title |
Malaria Journal |
container_volume |
6 |
container_issue |
1 |
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1766340941500645376 |