Alternative splicing of the Anopheles gambiae Dscam gene in diverse Plasmodium falciparum infections
Abstract Background In insects, including Anopheles mosquitoes, Dscam (Down syndrome cell adhesion molecule) appears to be involved in phagocytosis of pathogens, and shows pathogen-specific splice-form expression between divergent pathogen (or parasite) types (e.g. between bacteria and Plasmodium or...
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ftdoajarticles:oai:doaj.org/article:e7e7e52a16264eb0b18828752d2b9872 2023-05-15T15:06:31+02:00 Alternative splicing of the Anopheles gambiae Dscam gene in diverse Plasmodium falciparum infections Ranford-Cartwright Lisa C Obbard Darren J Yan Guiyun Afrane Yaw A Mwangi Jonathan M Smith Paul H Little Tom J 2011-06-01T00:00:00Z https://doi.org/10.1186/1475-2875-10-156 https://doaj.org/article/e7e7e52a16264eb0b18828752d2b9872 EN eng BMC http://www.malariajournal.com/content/10/1/156 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-10-156 1475-2875 https://doaj.org/article/e7e7e52a16264eb0b18828752d2b9872 Malaria Journal, Vol 10, Iss 1, p 156 (2011) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2011 ftdoajarticles https://doi.org/10.1186/1475-2875-10-156 2022-12-31T09:15:18Z Abstract Background In insects, including Anopheles mosquitoes, Dscam (Down syndrome cell adhesion molecule) appears to be involved in phagocytosis of pathogens, and shows pathogen-specific splice-form expression between divergent pathogen (or parasite) types (e.g. between bacteria and Plasmodium or between Plasmodium berghei and Plasmodium falciparum ). Here, data are presented from the first study of Dscam expression in response to genetic diversity within a parasite species. Methods In independent field and laboratory studies, a measure of Dscam splice-form diversity was compared between mosquitoes fed on blood that was free of P. falciparum to mosquitoes exposed to either single or mixed genotype infections of P. falciparum. Results Significant increases in Anopheles gambiae Dscam (AgDscam) receptor diversity were observed in parasite-exposed mosquitoes, but only weak evidence that AgDscam diversity rises further upon exposure to mixed genotype parasite infections was found. Finally, a cluster of AgDscam exon 4 variants that become especially common during Plasmodium invasion was identified. Conclusions While the data clearly indicate that AgDscam diversity increases with P. falciparum exposure, they do not suggest that AgDscam diversity rises further in response to increased parasite diversity. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 10 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Ranford-Cartwright Lisa C Obbard Darren J Yan Guiyun Afrane Yaw A Mwangi Jonathan M Smith Paul H Little Tom J Alternative splicing of the Anopheles gambiae Dscam gene in diverse Plasmodium falciparum infections |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background In insects, including Anopheles mosquitoes, Dscam (Down syndrome cell adhesion molecule) appears to be involved in phagocytosis of pathogens, and shows pathogen-specific splice-form expression between divergent pathogen (or parasite) types (e.g. between bacteria and Plasmodium or between Plasmodium berghei and Plasmodium falciparum ). Here, data are presented from the first study of Dscam expression in response to genetic diversity within a parasite species. Methods In independent field and laboratory studies, a measure of Dscam splice-form diversity was compared between mosquitoes fed on blood that was free of P. falciparum to mosquitoes exposed to either single or mixed genotype infections of P. falciparum. Results Significant increases in Anopheles gambiae Dscam (AgDscam) receptor diversity were observed in parasite-exposed mosquitoes, but only weak evidence that AgDscam diversity rises further upon exposure to mixed genotype parasite infections was found. Finally, a cluster of AgDscam exon 4 variants that become especially common during Plasmodium invasion was identified. Conclusions While the data clearly indicate that AgDscam diversity increases with P. falciparum exposure, they do not suggest that AgDscam diversity rises further in response to increased parasite diversity. |
format |
Article in Journal/Newspaper |
author |
Ranford-Cartwright Lisa C Obbard Darren J Yan Guiyun Afrane Yaw A Mwangi Jonathan M Smith Paul H Little Tom J |
author_facet |
Ranford-Cartwright Lisa C Obbard Darren J Yan Guiyun Afrane Yaw A Mwangi Jonathan M Smith Paul H Little Tom J |
author_sort |
Ranford-Cartwright Lisa C |
title |
Alternative splicing of the Anopheles gambiae Dscam gene in diverse Plasmodium falciparum infections |
title_short |
Alternative splicing of the Anopheles gambiae Dscam gene in diverse Plasmodium falciparum infections |
title_full |
Alternative splicing of the Anopheles gambiae Dscam gene in diverse Plasmodium falciparum infections |
title_fullStr |
Alternative splicing of the Anopheles gambiae Dscam gene in diverse Plasmodium falciparum infections |
title_full_unstemmed |
Alternative splicing of the Anopheles gambiae Dscam gene in diverse Plasmodium falciparum infections |
title_sort |
alternative splicing of the anopheles gambiae dscam gene in diverse plasmodium falciparum infections |
publisher |
BMC |
publishDate |
2011 |
url |
https://doi.org/10.1186/1475-2875-10-156 https://doaj.org/article/e7e7e52a16264eb0b18828752d2b9872 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 10, Iss 1, p 156 (2011) |
op_relation |
http://www.malariajournal.com/content/10/1/156 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-10-156 1475-2875 https://doaj.org/article/e7e7e52a16264eb0b18828752d2b9872 |
op_doi |
https://doi.org/10.1186/1475-2875-10-156 |
container_title |
Malaria Journal |
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10 |
container_issue |
1 |
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1766338105237831680 |