Hypertrophy of NADH-diaphorase positive myenteric neurons in rat jejunum after acute infection caused by Toxoplasma gondii
Toxoplasmosis, a globally distributed feline-associated zoonosis caused by the protozoan Toxoplasma gondii, affects birds and mammals, including humans. This study assesses the consequences of acute T. gondii infection for NADH-diaphorase positive myenteric neurons in rat jejunum. Ten male Wistar ra...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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Online Access: | https://doi.org/10.1590/S1678-91992010000200011 https://doaj.org/article/e7e1db695e874ef6a78b81c2696a11fd |
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ftdoajarticles:oai:doaj.org/article:e7e1db695e874ef6a78b81c2696a11fd 2023-05-15T15:05:07+02:00 Hypertrophy of NADH-diaphorase positive myenteric neurons in rat jejunum after acute infection caused by Toxoplasma gondii LS Pereira AV Silva EJA Araújo DMG Sant'Ana 2010-01-01T00:00:00Z https://doi.org/10.1590/S1678-91992010000200011 https://doaj.org/article/e7e1db695e874ef6a78b81c2696a11fd EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000200011 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992010000200011 1678-9199 https://doaj.org/article/e7e1db695e874ef6a78b81c2696a11fd Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 16, Iss 2, Pp 298-310 (2010) Toxoplasma gondii jejunum myenteric plexus Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2010 ftdoajarticles https://doi.org/10.1590/S1678-91992010000200011 2022-12-31T12:28:29Z Toxoplasmosis, a globally distributed feline-associated zoonosis caused by the protozoan Toxoplasma gondii, affects birds and mammals, including humans. This study assesses the consequences of acute T. gondii infection for NADH-diaphorase positive myenteric neurons in rat jejunum. Ten male Wistar rats (Rattus norvegicus) were divided into two groups: G1 (n = 5) and G2 (n = 5). Animals from G2 were orally inoculated with 500 genotype III (M7741) T. gondii oocysts. Twenty-four hours after inoculation, the animals were euthanized and had their jejuna removed, through laparotomy, and measured (length and width) to calculate their areas. Intestinal segments were submitted to NADH-diaphorase histochemistry to evidence the most metabolically active subpopulation of myenteric neurons. No changes were found in body weight; intestinal length, width or area; or neuron population density. Increase of body cell area and cytoplasm and decrease of nuclear area of the myenteric neurons of infected animals were observed by morphometric analysis. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 16 2 298 310 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Toxoplasma gondii jejunum myenteric plexus Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
Toxoplasma gondii jejunum myenteric plexus Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 LS Pereira AV Silva EJA Araújo DMG Sant'Ana Hypertrophy of NADH-diaphorase positive myenteric neurons in rat jejunum after acute infection caused by Toxoplasma gondii |
topic_facet |
Toxoplasma gondii jejunum myenteric plexus Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Toxoplasmosis, a globally distributed feline-associated zoonosis caused by the protozoan Toxoplasma gondii, affects birds and mammals, including humans. This study assesses the consequences of acute T. gondii infection for NADH-diaphorase positive myenteric neurons in rat jejunum. Ten male Wistar rats (Rattus norvegicus) were divided into two groups: G1 (n = 5) and G2 (n = 5). Animals from G2 were orally inoculated with 500 genotype III (M7741) T. gondii oocysts. Twenty-four hours after inoculation, the animals were euthanized and had their jejuna removed, through laparotomy, and measured (length and width) to calculate their areas. Intestinal segments were submitted to NADH-diaphorase histochemistry to evidence the most metabolically active subpopulation of myenteric neurons. No changes were found in body weight; intestinal length, width or area; or neuron population density. Increase of body cell area and cytoplasm and decrease of nuclear area of the myenteric neurons of infected animals were observed by morphometric analysis. |
format |
Article in Journal/Newspaper |
author |
LS Pereira AV Silva EJA Araújo DMG Sant'Ana |
author_facet |
LS Pereira AV Silva EJA Araújo DMG Sant'Ana |
author_sort |
LS Pereira |
title |
Hypertrophy of NADH-diaphorase positive myenteric neurons in rat jejunum after acute infection caused by Toxoplasma gondii |
title_short |
Hypertrophy of NADH-diaphorase positive myenteric neurons in rat jejunum after acute infection caused by Toxoplasma gondii |
title_full |
Hypertrophy of NADH-diaphorase positive myenteric neurons in rat jejunum after acute infection caused by Toxoplasma gondii |
title_fullStr |
Hypertrophy of NADH-diaphorase positive myenteric neurons in rat jejunum after acute infection caused by Toxoplasma gondii |
title_full_unstemmed |
Hypertrophy of NADH-diaphorase positive myenteric neurons in rat jejunum after acute infection caused by Toxoplasma gondii |
title_sort |
hypertrophy of nadh-diaphorase positive myenteric neurons in rat jejunum after acute infection caused by toxoplasma gondii |
publisher |
SciELO |
publishDate |
2010 |
url |
https://doi.org/10.1590/S1678-91992010000200011 https://doaj.org/article/e7e1db695e874ef6a78b81c2696a11fd |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 16, Iss 2, Pp 298-310 (2010) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000200011 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992010000200011 1678-9199 https://doaj.org/article/e7e1db695e874ef6a78b81c2696a11fd |
op_doi |
https://doi.org/10.1590/S1678-91992010000200011 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
16 |
container_issue |
2 |
container_start_page |
298 |
op_container_end_page |
310 |
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