Safety and tolerability of repeated doses of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in pregnancy: a systematic review and an aggregated data meta-analysis of randomized controlled trials
Abstract Background Malaria infection during pregnancy is an important cause of maternal and infant mortality and morbidity with the greatest effect being concentrated in sub-Saharan Africa. In areas of moderate to high malaria transmission, the World Health Organization (WHO) recommends the adminis...
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ftdoajarticles:oai:doaj.org/article:e7af3f34aeba4acc9eb55b43a7cc9f1c 2023-11-12T04:14:04+01:00 Safety and tolerability of repeated doses of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in pregnancy: a systematic review and an aggregated data meta-analysis of randomized controlled trials Esther Nthenya Muthoka Kedir Usmael Saba Mehari Embaye Abigiya Abebe Tigist Mesfin Dorothy Kazembe Mediha Ahmedin Stella Namuganza Monica Kahabuka Mary Gorret Atim Tsegahun Manyazewal 2023-10-01T00:00:00Z https://doi.org/10.1186/s12936-023-04757-2 https://doaj.org/article/e7af3f34aeba4acc9eb55b43a7cc9f1c EN eng BMC https://doi.org/10.1186/s12936-023-04757-2 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-023-04757-2 1475-2875 https://doaj.org/article/e7af3f34aeba4acc9eb55b43a7cc9f1c Malaria Journal, Vol 22, Iss 1, Pp 1-11 (2023) Malaria Pregnancy Intermittent preventive treatment Dihydroartemisinin-piperaquine Safety Tolerability Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2023 ftdoajarticles https://doi.org/10.1186/s12936-023-04757-2 2023-10-29T00:42:10Z Abstract Background Malaria infection during pregnancy is an important cause of maternal and infant mortality and morbidity with the greatest effect being concentrated in sub-Saharan Africa. In areas of moderate to high malaria transmission, the World Health Organization (WHO) recommends the administration of intermittent preventive treatment of malaria in pregnancy (IPTp) using sulfadoxine-pyrimethamine (SP) to be given to all pregnant women at each scheduled antenatal care visit at monthly intervals. However, there is concern that increased resistance has compromised its effectiveness. This has led to a need for evaluation of alternatives to SP for IPTp with dihydroartemisinin-piperaquine (DP) emerging as a very promising candidate. Thus, this systematic review and aggregated data meta-analysis was conducted to establish the safety and tolerability of repeated doses with DP in IPTp. Methods A systematic review and aggregated data meta-analysis of randomized controlled trials (RCTs) was performed by searching electronic databases of PubMed, Science Direct, ClinicalTrials.gov and Google Scholar. RCTs comparing IPTp DP versus recommended standard treatment for IPTp with these outcome measures were analyzed; change in QTc interval, serious adverse events (SAE), grade 3 or 4 adverse events possibly related to study drug and vomiting within 30 min after study drug administration. The search was performed up to 24th June 2023. Data was extracted from eligible studies and an aggregated data meta-analysis was carried out with data pooled as risk ratio (RR) with a 95% confidence interval (CI), using RevMan software (5.4). This study is registered with PROSPERO, CRD42022310041. Results Six RCTs involving 7969 participants were included in this systematic review and aggregated data meta-analysis. The pooled analysis showed that DP was associated with a change from baseline of the QTc interval although this change was not associated with cardiotoxicity. There was no statistically significant difference in the risk of ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Malaria Journal 22 1 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Malaria Pregnancy Intermittent preventive treatment Dihydroartemisinin-piperaquine Safety Tolerability Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Malaria Pregnancy Intermittent preventive treatment Dihydroartemisinin-piperaquine Safety Tolerability Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Esther Nthenya Muthoka Kedir Usmael Saba Mehari Embaye Abigiya Abebe Tigist Mesfin Dorothy Kazembe Mediha Ahmedin Stella Namuganza Monica Kahabuka Mary Gorret Atim Tsegahun Manyazewal Safety and tolerability of repeated doses of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in pregnancy: a systematic review and an aggregated data meta-analysis of randomized controlled trials |
topic_facet |
Malaria Pregnancy Intermittent preventive treatment Dihydroartemisinin-piperaquine Safety Tolerability Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Malaria infection during pregnancy is an important cause of maternal and infant mortality and morbidity with the greatest effect being concentrated in sub-Saharan Africa. In areas of moderate to high malaria transmission, the World Health Organization (WHO) recommends the administration of intermittent preventive treatment of malaria in pregnancy (IPTp) using sulfadoxine-pyrimethamine (SP) to be given to all pregnant women at each scheduled antenatal care visit at monthly intervals. However, there is concern that increased resistance has compromised its effectiveness. This has led to a need for evaluation of alternatives to SP for IPTp with dihydroartemisinin-piperaquine (DP) emerging as a very promising candidate. Thus, this systematic review and aggregated data meta-analysis was conducted to establish the safety and tolerability of repeated doses with DP in IPTp. Methods A systematic review and aggregated data meta-analysis of randomized controlled trials (RCTs) was performed by searching electronic databases of PubMed, Science Direct, ClinicalTrials.gov and Google Scholar. RCTs comparing IPTp DP versus recommended standard treatment for IPTp with these outcome measures were analyzed; change in QTc interval, serious adverse events (SAE), grade 3 or 4 adverse events possibly related to study drug and vomiting within 30 min after study drug administration. The search was performed up to 24th June 2023. Data was extracted from eligible studies and an aggregated data meta-analysis was carried out with data pooled as risk ratio (RR) with a 95% confidence interval (CI), using RevMan software (5.4). This study is registered with PROSPERO, CRD42022310041. Results Six RCTs involving 7969 participants were included in this systematic review and aggregated data meta-analysis. The pooled analysis showed that DP was associated with a change from baseline of the QTc interval although this change was not associated with cardiotoxicity. There was no statistically significant difference in the risk of ... |
format |
Article in Journal/Newspaper |
author |
Esther Nthenya Muthoka Kedir Usmael Saba Mehari Embaye Abigiya Abebe Tigist Mesfin Dorothy Kazembe Mediha Ahmedin Stella Namuganza Monica Kahabuka Mary Gorret Atim Tsegahun Manyazewal |
author_facet |
Esther Nthenya Muthoka Kedir Usmael Saba Mehari Embaye Abigiya Abebe Tigist Mesfin Dorothy Kazembe Mediha Ahmedin Stella Namuganza Monica Kahabuka Mary Gorret Atim Tsegahun Manyazewal |
author_sort |
Esther Nthenya Muthoka |
title |
Safety and tolerability of repeated doses of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in pregnancy: a systematic review and an aggregated data meta-analysis of randomized controlled trials |
title_short |
Safety and tolerability of repeated doses of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in pregnancy: a systematic review and an aggregated data meta-analysis of randomized controlled trials |
title_full |
Safety and tolerability of repeated doses of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in pregnancy: a systematic review and an aggregated data meta-analysis of randomized controlled trials |
title_fullStr |
Safety and tolerability of repeated doses of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in pregnancy: a systematic review and an aggregated data meta-analysis of randomized controlled trials |
title_full_unstemmed |
Safety and tolerability of repeated doses of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in pregnancy: a systematic review and an aggregated data meta-analysis of randomized controlled trials |
title_sort |
safety and tolerability of repeated doses of dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria in pregnancy: a systematic review and an aggregated data meta-analysis of randomized controlled trials |
publisher |
BMC |
publishDate |
2023 |
url |
https://doi.org/10.1186/s12936-023-04757-2 https://doaj.org/article/e7af3f34aeba4acc9eb55b43a7cc9f1c |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 22, Iss 1, Pp 1-11 (2023) |
op_relation |
https://doi.org/10.1186/s12936-023-04757-2 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-023-04757-2 1475-2875 https://doaj.org/article/e7af3f34aeba4acc9eb55b43a7cc9f1c |
op_doi |
https://doi.org/10.1186/s12936-023-04757-2 |
container_title |
Malaria Journal |
container_volume |
22 |
container_issue |
1 |
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1782331783437615104 |