Neurodevelopmental outcome of infants without central nervous system anomalies born to symptomatic RT-PCR ZIKV positive women.
An epidemic of Zika virus (ZIKV) infection began in Colombia in October 2015. Previous studies have identified a cause-effect relationship between fetal exposure to the ZIKV and the development of microcephaly and other central nervous system (CNS) anomalies with variable degrees of neurodevelopment...
Published in: | PLOS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2022
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0009854 https://doaj.org/article/e79f9d24b0d446e88c184df8035a5dde |
id |
ftdoajarticles:oai:doaj.org/article:e79f9d24b0d446e88c184df8035a5dde |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:e79f9d24b0d446e88c184df8035a5dde 2023-05-15T15:17:13+02:00 Neurodevelopmental outcome of infants without central nervous system anomalies born to symptomatic RT-PCR ZIKV positive women. Luis Alfonso Díaz-Martínez Mario Augusto Rojas Luz Stella Pinilla-García Carlos Hernán Becerra-Mojica Luis Alfonso Pérez-Vera Luz Ángela Gutiérrez-Sánchez Gustavo Adolfo Contreras-García Carol Gisela Rueda-Ordoñez Luis Villar 2022-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009854 https://doaj.org/article/e79f9d24b0d446e88c184df8035a5dde EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009854 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009854 https://doaj.org/article/e79f9d24b0d446e88c184df8035a5dde PLoS Neglected Tropical Diseases, Vol 16, Iss 3, p e0009854 (2022) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2022 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009854 2022-12-30T23:06:12Z An epidemic of Zika virus (ZIKV) infection began in Colombia in October 2015. Previous studies have identified a cause-effect relationship between fetal exposure to the ZIKV and the development of microcephaly and other central nervous system (CNS) anomalies with variable degrees of neurodevelopmental delay. Less is known about the neurodevelopmental outcome of infants without CNS anomalies born to symptomatic ZIKV RT-PCR-positive women. We aimed to compare the neurodevelopmental outcome of these infants to a control group of infants without CNS anomalies born to asymptomatic ZIKV RT-PCR negative women who did not seroconvert during pregnancy. Participating infants were categorized according to ZIKV maternal exposure. Women with symptomatology suggestive of ZIKV infection and a positive RT-PCR for ZIKV were categorized as ZIKV-exposed. Maternal controls (ZIKV unexposed) from the same geographic area were subsequently captured during the tail end of the epidemic through a partner project, the ZIKAlliance, whose aim was to determine the prevalence of ZIKV in pregnant women. Infant survivors from these two groups of pregnant women had a neurodevelopmental evaluation at 12, 18, and 24 months corrected age (CA). The ZIKV-exposed women were found to be older, had less subsidized health care, had a higher percentage of women in middle-class socioeconomic strata, had higher technical and university education, were less likely to be living with a partner, and had higher rates of pregnancy comorbidity and premature births than ZIKV unexposed women. Compared to infants born to ZIKV unexposed women (unexposed), infants born to ZIKV exposed women (exposed) were of lower gestational age and required more speech and occupational therapy services. No differences between groups were observed in the proportion of cut-off scores <70 on the Bayley-III Scale at 12, 18, and 24 months for motor, language, and cognitive domains. When a cut-off of <85 was used, a higher percentage of motor and cognitive impairment was observed in ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 16 3 e0009854 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Luis Alfonso Díaz-Martínez Mario Augusto Rojas Luz Stella Pinilla-García Carlos Hernán Becerra-Mojica Luis Alfonso Pérez-Vera Luz Ángela Gutiérrez-Sánchez Gustavo Adolfo Contreras-García Carol Gisela Rueda-Ordoñez Luis Villar Neurodevelopmental outcome of infants without central nervous system anomalies born to symptomatic RT-PCR ZIKV positive women. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
An epidemic of Zika virus (ZIKV) infection began in Colombia in October 2015. Previous studies have identified a cause-effect relationship between fetal exposure to the ZIKV and the development of microcephaly and other central nervous system (CNS) anomalies with variable degrees of neurodevelopmental delay. Less is known about the neurodevelopmental outcome of infants without CNS anomalies born to symptomatic ZIKV RT-PCR-positive women. We aimed to compare the neurodevelopmental outcome of these infants to a control group of infants without CNS anomalies born to asymptomatic ZIKV RT-PCR negative women who did not seroconvert during pregnancy. Participating infants were categorized according to ZIKV maternal exposure. Women with symptomatology suggestive of ZIKV infection and a positive RT-PCR for ZIKV were categorized as ZIKV-exposed. Maternal controls (ZIKV unexposed) from the same geographic area were subsequently captured during the tail end of the epidemic through a partner project, the ZIKAlliance, whose aim was to determine the prevalence of ZIKV in pregnant women. Infant survivors from these two groups of pregnant women had a neurodevelopmental evaluation at 12, 18, and 24 months corrected age (CA). The ZIKV-exposed women were found to be older, had less subsidized health care, had a higher percentage of women in middle-class socioeconomic strata, had higher technical and university education, were less likely to be living with a partner, and had higher rates of pregnancy comorbidity and premature births than ZIKV unexposed women. Compared to infants born to ZIKV unexposed women (unexposed), infants born to ZIKV exposed women (exposed) were of lower gestational age and required more speech and occupational therapy services. No differences between groups were observed in the proportion of cut-off scores <70 on the Bayley-III Scale at 12, 18, and 24 months for motor, language, and cognitive domains. When a cut-off of <85 was used, a higher percentage of motor and cognitive impairment was observed in ... |
format |
Article in Journal/Newspaper |
author |
Luis Alfonso Díaz-Martínez Mario Augusto Rojas Luz Stella Pinilla-García Carlos Hernán Becerra-Mojica Luis Alfonso Pérez-Vera Luz Ángela Gutiérrez-Sánchez Gustavo Adolfo Contreras-García Carol Gisela Rueda-Ordoñez Luis Villar |
author_facet |
Luis Alfonso Díaz-Martínez Mario Augusto Rojas Luz Stella Pinilla-García Carlos Hernán Becerra-Mojica Luis Alfonso Pérez-Vera Luz Ángela Gutiérrez-Sánchez Gustavo Adolfo Contreras-García Carol Gisela Rueda-Ordoñez Luis Villar |
author_sort |
Luis Alfonso Díaz-Martínez |
title |
Neurodevelopmental outcome of infants without central nervous system anomalies born to symptomatic RT-PCR ZIKV positive women. |
title_short |
Neurodevelopmental outcome of infants without central nervous system anomalies born to symptomatic RT-PCR ZIKV positive women. |
title_full |
Neurodevelopmental outcome of infants without central nervous system anomalies born to symptomatic RT-PCR ZIKV positive women. |
title_fullStr |
Neurodevelopmental outcome of infants without central nervous system anomalies born to symptomatic RT-PCR ZIKV positive women. |
title_full_unstemmed |
Neurodevelopmental outcome of infants without central nervous system anomalies born to symptomatic RT-PCR ZIKV positive women. |
title_sort |
neurodevelopmental outcome of infants without central nervous system anomalies born to symptomatic rt-pcr zikv positive women. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2022 |
url |
https://doi.org/10.1371/journal.pntd.0009854 https://doaj.org/article/e79f9d24b0d446e88c184df8035a5dde |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 16, Iss 3, p e0009854 (2022) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009854 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009854 https://doaj.org/article/e79f9d24b0d446e88c184df8035a5dde |
op_doi |
https://doi.org/10.1371/journal.pntd.0009854 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
16 |
container_issue |
3 |
container_start_page |
e0009854 |
_version_ |
1766347486901829632 |