Diagnostic performance of C-reactive protein level and its role as a potential biomarker of severe dengue in adults
Objective: To determine the relationship between C-reactive protein (CRP) level and the severity of dengue and the potential use of CRP in predicting acute dengue infection. Methods: A prospective observational study was performed on dengue patients admitted to a tertiary care hospital in southern I...
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ftdoajarticles:oai:doaj.org/article:e77e69974a9b42ebab0708b09a6169b8 2023-05-15T15:13:49+02:00 Diagnostic performance of C-reactive protein level and its role as a potential biomarker of severe dengue in adults Raghavendra Rao Snehal Nayak Akhilesh K Pandey Shobha U Kamath 2020-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.289440 https://doaj.org/article/e77e69974a9b42ebab0708b09a6169b8 EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2020;volume=13;issue=8;spage=358;epage=365;aulast=Rao https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.289440 https://doaj.org/article/e77e69974a9b42ebab0708b09a6169b8 Asian Pacific Journal of Tropical Medicine, Vol 13, Iss 8, Pp 358-365 (2020) vector-borne arbovirus inflammation biochemical tropical disease Arctic medicine. Tropical medicine RC955-962 article 2020 ftdoajarticles https://doi.org/10.4103/1995-7645.289440 2022-12-31T03:06:27Z Objective: To determine the relationship between C-reactive protein (CRP) level and the severity of dengue and the potential use of CRP in predicting acute dengue infection. Methods: A prospective observational study was performed on dengue patients admitted to a tertiary care hospital in southern India. All patients of age above 18 years, diagnosed with dengue were included in the study. The detailed laboratory parameters pertaining to dengue were recorded. CRP levels were estimated and compared between groups i.e. severe and non-severe dengue. CRP cut-off value was detected using the receiver-operator curve. Results: Totally 98 patients with a mean age of 40 years were included. Among them, 11.2% of the patients suffered from severe dengue, 54.1% of the cases had non-severe dengue without warning signs, and 34.7% had non-severe dengue with warning signs. The median CRP was significantly higher in patients with severe dengue compared to patients with non-severe dengue (96.2 mg/dL vs. 5.3 mg/dL). Univariate logistic regression analysis showed that the odd’s ratio (OR) of CRP was 1.053 (P≤0.001, 95% CI=1.029-1.078). CRP at a cutoff value of 21.6 mg/L (0.929 AUC) had excellent sensitivity (100%) and specificity (81.6%) in predicting severe dengue infection. Multivariate logistic regression analysis showed that CRP (OR=1.089, P=0.013) and ALT (OR=1.010, P=0.034) were statistically significant independent predictors of dengue severity. Conclusions: CRP level could be used as a potential biomarker to predict severity of dengue in adults. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Medicine 13 8 358 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
vector-borne arbovirus inflammation biochemical tropical disease Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
vector-borne arbovirus inflammation biochemical tropical disease Arctic medicine. Tropical medicine RC955-962 Raghavendra Rao Snehal Nayak Akhilesh K Pandey Shobha U Kamath Diagnostic performance of C-reactive protein level and its role as a potential biomarker of severe dengue in adults |
topic_facet |
vector-borne arbovirus inflammation biochemical tropical disease Arctic medicine. Tropical medicine RC955-962 |
description |
Objective: To determine the relationship between C-reactive protein (CRP) level and the severity of dengue and the potential use of CRP in predicting acute dengue infection. Methods: A prospective observational study was performed on dengue patients admitted to a tertiary care hospital in southern India. All patients of age above 18 years, diagnosed with dengue were included in the study. The detailed laboratory parameters pertaining to dengue were recorded. CRP levels were estimated and compared between groups i.e. severe and non-severe dengue. CRP cut-off value was detected using the receiver-operator curve. Results: Totally 98 patients with a mean age of 40 years were included. Among them, 11.2% of the patients suffered from severe dengue, 54.1% of the cases had non-severe dengue without warning signs, and 34.7% had non-severe dengue with warning signs. The median CRP was significantly higher in patients with severe dengue compared to patients with non-severe dengue (96.2 mg/dL vs. 5.3 mg/dL). Univariate logistic regression analysis showed that the odd’s ratio (OR) of CRP was 1.053 (P≤0.001, 95% CI=1.029-1.078). CRP at a cutoff value of 21.6 mg/L (0.929 AUC) had excellent sensitivity (100%) and specificity (81.6%) in predicting severe dengue infection. Multivariate logistic regression analysis showed that CRP (OR=1.089, P=0.013) and ALT (OR=1.010, P=0.034) were statistically significant independent predictors of dengue severity. Conclusions: CRP level could be used as a potential biomarker to predict severity of dengue in adults. |
format |
Article in Journal/Newspaper |
author |
Raghavendra Rao Snehal Nayak Akhilesh K Pandey Shobha U Kamath |
author_facet |
Raghavendra Rao Snehal Nayak Akhilesh K Pandey Shobha U Kamath |
author_sort |
Raghavendra Rao |
title |
Diagnostic performance of C-reactive protein level and its role as a potential biomarker of severe dengue in adults |
title_short |
Diagnostic performance of C-reactive protein level and its role as a potential biomarker of severe dengue in adults |
title_full |
Diagnostic performance of C-reactive protein level and its role as a potential biomarker of severe dengue in adults |
title_fullStr |
Diagnostic performance of C-reactive protein level and its role as a potential biomarker of severe dengue in adults |
title_full_unstemmed |
Diagnostic performance of C-reactive protein level and its role as a potential biomarker of severe dengue in adults |
title_sort |
diagnostic performance of c-reactive protein level and its role as a potential biomarker of severe dengue in adults |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2020 |
url |
https://doi.org/10.4103/1995-7645.289440 https://doaj.org/article/e77e69974a9b42ebab0708b09a6169b8 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 13, Iss 8, Pp 358-365 (2020) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2020;volume=13;issue=8;spage=358;epage=365;aulast=Rao https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.289440 https://doaj.org/article/e77e69974a9b42ebab0708b09a6169b8 |
op_doi |
https://doi.org/10.4103/1995-7645.289440 |
container_title |
Asian Pacific Journal of Tropical Medicine |
container_volume |
13 |
container_issue |
8 |
container_start_page |
358 |
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1766344332078481408 |