Review of 21 cases of mycetoma from 1991 to 2014 in Rio de Janeiro, Brazil.
Mycetoma is caused by the subcutaneous inoculation of filamentous fungi or aerobic filamentous bacteria that form grains in the tissue. The purpose of this study is to describe the epidemiologic, clinic, laboratory, and therapeutic characteristics of patients with mycetoma at the Oswaldo Cruz Founda...
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ftdoajarticles:oai:doaj.org/article:e749cb2c72fc415eaa9139e47152dd3a 2023-05-15T15:15:02+02:00 Review of 21 cases of mycetoma from 1991 to 2014 in Rio de Janeiro, Brazil. Felipe Maurício Soeiro Sampaio Bodo Wanke Dayvison Francis Saraiva Freitas Janice Mery Chicarino de Oliveira Coelho Maria Clara Gutierrez Galhardo Marcelo Rosandiski Lyra Maria Cristina da Silva Lourenço Rodrigo de Almeida Paes Antonio Carlos Francesconi do Valle 2017-02-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005301 https://doaj.org/article/e749cb2c72fc415eaa9139e47152dd3a EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5336304?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005301 https://doaj.org/article/e749cb2c72fc415eaa9139e47152dd3a PLoS Neglected Tropical Diseases, Vol 11, Iss 2, p e0005301 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005301 2023-01-08T01:28:15Z Mycetoma is caused by the subcutaneous inoculation of filamentous fungi or aerobic filamentous bacteria that form grains in the tissue. The purpose of this study is to describe the epidemiologic, clinic, laboratory, and therapeutic characteristics of patients with mycetoma at the Oswaldo Cruz Foundation in Rio de Janeiro, Brazil, between 1991 and 2014. Twenty-one cases of mycetoma were included in the study. There was a predominance of male patients (1.3:1) and the average patient age was 46 years. The majority of the cases were from the Southeast region of Brazil and the feet were the most affected anatomical region (80.95%). Eumycetoma prevailed over actinomycetoma (61.9% and 38.1% respectively). Eumycetoma patients had positive cultures in 8 of 13 cases, with isolation of Scedosporium apiospermum species complex (n = 3), Madurella mycetomatis (n = 2) and Acremonium spp. (n = 1). Two cases presented sterile mycelium and five were negative. Six of 8 actinomycetoma cases had cultures that were identified as Nocardia spp. (n = 3), Nocardia brasiliensis (n = 2), and Nocardia asteroides (n = 1). Imaging tests were performed on all but one patients, and bone destruction was identified in 9 cases (42.68%). All eumycetoma cases were treated with itraconazole monotherapy or combined with fluconazole, terbinafine, or amphotericin B. Actinomycetoma cases were treated with sulfamethoxazole plus trimethoprim or combined with cycles of amikacin sulphate. Surgical procedures were performed in 9 (69.2%) eumycetoma and in 3 (37.5%) actinomycetoma cases, with one amputation case in each group. Clinical cure occurred in 11 cases (7 for eumycetoma and 4 for actinomycetoma), and recurrence was documented in 4 of 21 cases. No deaths were recorded during the study. Despite of the scarcity of mycetoma in our institution the cases presented reflect the wide clinical spectrum and difficulties to take care of this neglected disease. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 11 2 e0005301 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Felipe Maurício Soeiro Sampaio Bodo Wanke Dayvison Francis Saraiva Freitas Janice Mery Chicarino de Oliveira Coelho Maria Clara Gutierrez Galhardo Marcelo Rosandiski Lyra Maria Cristina da Silva Lourenço Rodrigo de Almeida Paes Antonio Carlos Francesconi do Valle Review of 21 cases of mycetoma from 1991 to 2014 in Rio de Janeiro, Brazil. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Mycetoma is caused by the subcutaneous inoculation of filamentous fungi or aerobic filamentous bacteria that form grains in the tissue. The purpose of this study is to describe the epidemiologic, clinic, laboratory, and therapeutic characteristics of patients with mycetoma at the Oswaldo Cruz Foundation in Rio de Janeiro, Brazil, between 1991 and 2014. Twenty-one cases of mycetoma were included in the study. There was a predominance of male patients (1.3:1) and the average patient age was 46 years. The majority of the cases were from the Southeast region of Brazil and the feet were the most affected anatomical region (80.95%). Eumycetoma prevailed over actinomycetoma (61.9% and 38.1% respectively). Eumycetoma patients had positive cultures in 8 of 13 cases, with isolation of Scedosporium apiospermum species complex (n = 3), Madurella mycetomatis (n = 2) and Acremonium spp. (n = 1). Two cases presented sterile mycelium and five were negative. Six of 8 actinomycetoma cases had cultures that were identified as Nocardia spp. (n = 3), Nocardia brasiliensis (n = 2), and Nocardia asteroides (n = 1). Imaging tests were performed on all but one patients, and bone destruction was identified in 9 cases (42.68%). All eumycetoma cases were treated with itraconazole monotherapy or combined with fluconazole, terbinafine, or amphotericin B. Actinomycetoma cases were treated with sulfamethoxazole plus trimethoprim or combined with cycles of amikacin sulphate. Surgical procedures were performed in 9 (69.2%) eumycetoma and in 3 (37.5%) actinomycetoma cases, with one amputation case in each group. Clinical cure occurred in 11 cases (7 for eumycetoma and 4 for actinomycetoma), and recurrence was documented in 4 of 21 cases. No deaths were recorded during the study. Despite of the scarcity of mycetoma in our institution the cases presented reflect the wide clinical spectrum and difficulties to take care of this neglected disease. |
format |
Article in Journal/Newspaper |
author |
Felipe Maurício Soeiro Sampaio Bodo Wanke Dayvison Francis Saraiva Freitas Janice Mery Chicarino de Oliveira Coelho Maria Clara Gutierrez Galhardo Marcelo Rosandiski Lyra Maria Cristina da Silva Lourenço Rodrigo de Almeida Paes Antonio Carlos Francesconi do Valle |
author_facet |
Felipe Maurício Soeiro Sampaio Bodo Wanke Dayvison Francis Saraiva Freitas Janice Mery Chicarino de Oliveira Coelho Maria Clara Gutierrez Galhardo Marcelo Rosandiski Lyra Maria Cristina da Silva Lourenço Rodrigo de Almeida Paes Antonio Carlos Francesconi do Valle |
author_sort |
Felipe Maurício Soeiro Sampaio |
title |
Review of 21 cases of mycetoma from 1991 to 2014 in Rio de Janeiro, Brazil. |
title_short |
Review of 21 cases of mycetoma from 1991 to 2014 in Rio de Janeiro, Brazil. |
title_full |
Review of 21 cases of mycetoma from 1991 to 2014 in Rio de Janeiro, Brazil. |
title_fullStr |
Review of 21 cases of mycetoma from 1991 to 2014 in Rio de Janeiro, Brazil. |
title_full_unstemmed |
Review of 21 cases of mycetoma from 1991 to 2014 in Rio de Janeiro, Brazil. |
title_sort |
review of 21 cases of mycetoma from 1991 to 2014 in rio de janeiro, brazil. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0005301 https://doaj.org/article/e749cb2c72fc415eaa9139e47152dd3a |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 2, p e0005301 (2017) |
op_relation |
http://europepmc.org/articles/PMC5336304?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005301 https://doaj.org/article/e749cb2c72fc415eaa9139e47152dd3a |
op_doi |
https://doi.org/10.1371/journal.pntd.0005301 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
11 |
container_issue |
2 |
container_start_page |
e0005301 |
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1766345428303872000 |