Contemporary radiooncological management of bone metastases from breast cancer: factors associated with prescription of different fractionation regimens (short or long course) in a rural part of North Norway with long travel distance
The aim of this study was to reduce barriers that prevent implementation of evidence-based recommendations about single-fraction palliative radiotherapy (PRT) and to demonstrate that single-fraction PRT yields similar outcomes as long-course treatment (≥10 fractions) in patients with bone metastases...
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ftdoajarticles:oai:doaj.org/article:e73bd7ca41384987a69567e1979a4cec 2023-05-15T15:09:55+02:00 Contemporary radiooncological management of bone metastases from breast cancer: factors associated with prescription of different fractionation regimens (short or long course) in a rural part of North Norway with long travel distance Carsten Nieder Astrid Dalhaug Ellinor Haukland Bård Mannsåker Adam Pawinski 2017-01-01T00:00:00Z https://doi.org/10.1080/22423982.2016.1270080 https://doaj.org/article/e73bd7ca41384987a69567e1979a4cec EN eng Taylor & Francis Group http://dx.doi.org/10.1080/22423982.2016.1270080 https://doaj.org/toc/2242-3982 2242-3982 doi:10.1080/22423982.2016.1270080 https://doaj.org/article/e73bd7ca41384987a69567e1979a4cec International Journal of Circumpolar Health, Vol 76, Iss 1 (2017) Breast cancer bone metastases prognostic factors radiotherapy palliative therapy Arctic medicine. Tropical medicine RC955-962 article 2017 ftdoajarticles https://doi.org/10.1080/22423982.2016.1270080 2022-12-31T07:22:39Z The aim of this study was to reduce barriers that prevent implementation of evidence-based recommendations about single-fraction palliative radiotherapy (PRT) and to demonstrate that single-fraction PRT yields similar outcomes as long-course treatment (≥10 fractions) in patients with bone metastases from breast cancer. This retrospective study (2007–2014) included 118 Norwegian female patients. All patients received guideline-conform systemic therapy including bone-targeting agents. Median survival was 12.7 months. Long-course PRT was prescribed in 60% of patients, while 21% had PRT with a single fraction of 8 Gy to at least one target. Reirradiation rate was not significantly higher after 8 Gy (9%, compared to 5% after long-course PRT and 6% after 4 Gy x5). Patients with favorable baseline characteristics such as younger age and good performance status (PS) were significantly more likely to receive long-course PRT. Biological subtype and comorbidity did not correlate with fractionation. Prognosis was influenced by biological subtype, extra-skeletal disease extent, severe anemia and abnormal CRP. The limited need for reirradiation after single fraction PRT might encourage physicians to prescribe this convenient regimen, which would improve resource utilization. Even patients with PS3 had a median survival of 3 months, which indicates that they could experience worthwhile clinical benefit. Article in Journal/Newspaper Arctic Circumpolar Health International Journal of Circumpolar Health North Norway Directory of Open Access Journals: DOAJ Articles Arctic Norway International Journal of Circumpolar Health 76 1 1270080 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Breast cancer bone metastases prognostic factors radiotherapy palliative therapy Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Breast cancer bone metastases prognostic factors radiotherapy palliative therapy Arctic medicine. Tropical medicine RC955-962 Carsten Nieder Astrid Dalhaug Ellinor Haukland Bård Mannsåker Adam Pawinski Contemporary radiooncological management of bone metastases from breast cancer: factors associated with prescription of different fractionation regimens (short or long course) in a rural part of North Norway with long travel distance |
topic_facet |
Breast cancer bone metastases prognostic factors radiotherapy palliative therapy Arctic medicine. Tropical medicine RC955-962 |
description |
The aim of this study was to reduce barriers that prevent implementation of evidence-based recommendations about single-fraction palliative radiotherapy (PRT) and to demonstrate that single-fraction PRT yields similar outcomes as long-course treatment (≥10 fractions) in patients with bone metastases from breast cancer. This retrospective study (2007–2014) included 118 Norwegian female patients. All patients received guideline-conform systemic therapy including bone-targeting agents. Median survival was 12.7 months. Long-course PRT was prescribed in 60% of patients, while 21% had PRT with a single fraction of 8 Gy to at least one target. Reirradiation rate was not significantly higher after 8 Gy (9%, compared to 5% after long-course PRT and 6% after 4 Gy x5). Patients with favorable baseline characteristics such as younger age and good performance status (PS) were significantly more likely to receive long-course PRT. Biological subtype and comorbidity did not correlate with fractionation. Prognosis was influenced by biological subtype, extra-skeletal disease extent, severe anemia and abnormal CRP. The limited need for reirradiation after single fraction PRT might encourage physicians to prescribe this convenient regimen, which would improve resource utilization. Even patients with PS3 had a median survival of 3 months, which indicates that they could experience worthwhile clinical benefit. |
format |
Article in Journal/Newspaper |
author |
Carsten Nieder Astrid Dalhaug Ellinor Haukland Bård Mannsåker Adam Pawinski |
author_facet |
Carsten Nieder Astrid Dalhaug Ellinor Haukland Bård Mannsåker Adam Pawinski |
author_sort |
Carsten Nieder |
title |
Contemporary radiooncological management of bone metastases from breast cancer: factors associated with prescription of different fractionation regimens (short or long course) in a rural part of North Norway with long travel distance |
title_short |
Contemporary radiooncological management of bone metastases from breast cancer: factors associated with prescription of different fractionation regimens (short or long course) in a rural part of North Norway with long travel distance |
title_full |
Contemporary radiooncological management of bone metastases from breast cancer: factors associated with prescription of different fractionation regimens (short or long course) in a rural part of North Norway with long travel distance |
title_fullStr |
Contemporary radiooncological management of bone metastases from breast cancer: factors associated with prescription of different fractionation regimens (short or long course) in a rural part of North Norway with long travel distance |
title_full_unstemmed |
Contemporary radiooncological management of bone metastases from breast cancer: factors associated with prescription of different fractionation regimens (short or long course) in a rural part of North Norway with long travel distance |
title_sort |
contemporary radiooncological management of bone metastases from breast cancer: factors associated with prescription of different fractionation regimens (short or long course) in a rural part of north norway with long travel distance |
publisher |
Taylor & Francis Group |
publishDate |
2017 |
url |
https://doi.org/10.1080/22423982.2016.1270080 https://doaj.org/article/e73bd7ca41384987a69567e1979a4cec |
geographic |
Arctic Norway |
geographic_facet |
Arctic Norway |
genre |
Arctic Circumpolar Health International Journal of Circumpolar Health North Norway |
genre_facet |
Arctic Circumpolar Health International Journal of Circumpolar Health North Norway |
op_source |
International Journal of Circumpolar Health, Vol 76, Iss 1 (2017) |
op_relation |
http://dx.doi.org/10.1080/22423982.2016.1270080 https://doaj.org/toc/2242-3982 2242-3982 doi:10.1080/22423982.2016.1270080 https://doaj.org/article/e73bd7ca41384987a69567e1979a4cec |
op_doi |
https://doi.org/10.1080/22423982.2016.1270080 |
container_title |
International Journal of Circumpolar Health |
container_volume |
76 |
container_issue |
1 |
container_start_page |
1270080 |
_version_ |
1766341012871970816 |