Comparative Estimates of Crude and Effective Coverage of Measles Immunization in Low-Resource Settings: Findings from Salud Mesoamérica 2015.
Timely and accurate measurement of population protection against measles is critical for decision-making and prevention of outbreaks. However, little is known about how survey-based estimates of immunization (crude coverage) compare to the seroprevalence of antibodies (effective coverage), particula...
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ftdoajarticles:oai:doaj.org/article:e7300b630a314bbf908df6725e01f113 2023-05-15T17:36:02+02:00 Comparative Estimates of Crude and Effective Coverage of Measles Immunization in Low-Resource Settings: Findings from Salud Mesoamérica 2015. K Ellicott Colson Paola Zúñiga-Brenes Diego Ríos-Zertuche Carlos J Conde-Glez Marielle C Gagnier Erin Palmisano Dharani Ranganathan Gulnoza Usmanova Benito Salvatierra Austreberta Nazar Ignez Tristao Emmanuelle Sanchez Monin Brent W Anderson Annie Haakenstad Tasha Murphy Stephen Lim Bernardo Hernandez Rafael Lozano Emma Iriarte Ali H Mokdad 2015-01-01T00:00:00Z https://doi.org/10.1371/journal.pone.0130697 https://doaj.org/article/e7300b630a314bbf908df6725e01f113 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4489764?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0130697 https://doaj.org/article/e7300b630a314bbf908df6725e01f113 PLoS ONE, Vol 10, Iss 7, p e0130697 (2015) Medicine R Science Q article 2015 ftdoajarticles https://doi.org/10.1371/journal.pone.0130697 2022-12-31T14:32:45Z Timely and accurate measurement of population protection against measles is critical for decision-making and prevention of outbreaks. However, little is known about how survey-based estimates of immunization (crude coverage) compare to the seroprevalence of antibodies (effective coverage), particularly in low-resource settings. In poor areas of Mexico and Nicaragua, we used household surveys to gather information on measles immunization from child health cards and caregiver recall. We also collected dried blood spots (DBS) from children aged 12 to 23 months to compare crude and effective coverage of measles immunization. We used survey-weighted logistic regression to identify individual, maternal, household, community, and health facility characteristics that predict gaps between crude coverage and effective coverage. We found that crude coverage was significantly higher than effective coverage (83% versus 68% in Mexico; 85% versus 50% in Nicaragua). A large proportion of children (19% in Mexico; 43% in Nicaragua) had health card documentation of measles immunization but lacked antibodies. These discrepancies varied from 0% to 100% across municipalities in each country. In multivariate analyses, card-positive children in Mexico were more likely to lack antibodies if they resided in urban areas or the jurisdiction of De Los Llanos. In contrast, card-positive children in Nicaragua were more likely to lack antibodies if they resided in rural areas or the North Atlantic region, had low weight-for-age, or attended health facilities with a greater number of refrigerators. Findings highlight that reliance on child health cards to measure population protection against measles is unwise. We call for the evaluation of immunization programs using serological methods, especially in poor areas where the cold chain is likely to be compromised. Identification of within-country variation in effective coverage of measles immunization will allow researchers and public health professionals to address challenges in current ... Article in Journal/Newspaper North Atlantic Directory of Open Access Journals: DOAJ Articles PLOS ONE 10 7 e0130697 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Medicine R Science Q |
spellingShingle |
Medicine R Science Q K Ellicott Colson Paola Zúñiga-Brenes Diego Ríos-Zertuche Carlos J Conde-Glez Marielle C Gagnier Erin Palmisano Dharani Ranganathan Gulnoza Usmanova Benito Salvatierra Austreberta Nazar Ignez Tristao Emmanuelle Sanchez Monin Brent W Anderson Annie Haakenstad Tasha Murphy Stephen Lim Bernardo Hernandez Rafael Lozano Emma Iriarte Ali H Mokdad Comparative Estimates of Crude and Effective Coverage of Measles Immunization in Low-Resource Settings: Findings from Salud Mesoamérica 2015. |
topic_facet |
Medicine R Science Q |
description |
Timely and accurate measurement of population protection against measles is critical for decision-making and prevention of outbreaks. However, little is known about how survey-based estimates of immunization (crude coverage) compare to the seroprevalence of antibodies (effective coverage), particularly in low-resource settings. In poor areas of Mexico and Nicaragua, we used household surveys to gather information on measles immunization from child health cards and caregiver recall. We also collected dried blood spots (DBS) from children aged 12 to 23 months to compare crude and effective coverage of measles immunization. We used survey-weighted logistic regression to identify individual, maternal, household, community, and health facility characteristics that predict gaps between crude coverage and effective coverage. We found that crude coverage was significantly higher than effective coverage (83% versus 68% in Mexico; 85% versus 50% in Nicaragua). A large proportion of children (19% in Mexico; 43% in Nicaragua) had health card documentation of measles immunization but lacked antibodies. These discrepancies varied from 0% to 100% across municipalities in each country. In multivariate analyses, card-positive children in Mexico were more likely to lack antibodies if they resided in urban areas or the jurisdiction of De Los Llanos. In contrast, card-positive children in Nicaragua were more likely to lack antibodies if they resided in rural areas or the North Atlantic region, had low weight-for-age, or attended health facilities with a greater number of refrigerators. Findings highlight that reliance on child health cards to measure population protection against measles is unwise. We call for the evaluation of immunization programs using serological methods, especially in poor areas where the cold chain is likely to be compromised. Identification of within-country variation in effective coverage of measles immunization will allow researchers and public health professionals to address challenges in current ... |
format |
Article in Journal/Newspaper |
author |
K Ellicott Colson Paola Zúñiga-Brenes Diego Ríos-Zertuche Carlos J Conde-Glez Marielle C Gagnier Erin Palmisano Dharani Ranganathan Gulnoza Usmanova Benito Salvatierra Austreberta Nazar Ignez Tristao Emmanuelle Sanchez Monin Brent W Anderson Annie Haakenstad Tasha Murphy Stephen Lim Bernardo Hernandez Rafael Lozano Emma Iriarte Ali H Mokdad |
author_facet |
K Ellicott Colson Paola Zúñiga-Brenes Diego Ríos-Zertuche Carlos J Conde-Glez Marielle C Gagnier Erin Palmisano Dharani Ranganathan Gulnoza Usmanova Benito Salvatierra Austreberta Nazar Ignez Tristao Emmanuelle Sanchez Monin Brent W Anderson Annie Haakenstad Tasha Murphy Stephen Lim Bernardo Hernandez Rafael Lozano Emma Iriarte Ali H Mokdad |
author_sort |
K Ellicott Colson |
title |
Comparative Estimates of Crude and Effective Coverage of Measles Immunization in Low-Resource Settings: Findings from Salud Mesoamérica 2015. |
title_short |
Comparative Estimates of Crude and Effective Coverage of Measles Immunization in Low-Resource Settings: Findings from Salud Mesoamérica 2015. |
title_full |
Comparative Estimates of Crude and Effective Coverage of Measles Immunization in Low-Resource Settings: Findings from Salud Mesoamérica 2015. |
title_fullStr |
Comparative Estimates of Crude and Effective Coverage of Measles Immunization in Low-Resource Settings: Findings from Salud Mesoamérica 2015. |
title_full_unstemmed |
Comparative Estimates of Crude and Effective Coverage of Measles Immunization in Low-Resource Settings: Findings from Salud Mesoamérica 2015. |
title_sort |
comparative estimates of crude and effective coverage of measles immunization in low-resource settings: findings from salud mesoamérica 2015. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2015 |
url |
https://doi.org/10.1371/journal.pone.0130697 https://doaj.org/article/e7300b630a314bbf908df6725e01f113 |
genre |
North Atlantic |
genre_facet |
North Atlantic |
op_source |
PLoS ONE, Vol 10, Iss 7, p e0130697 (2015) |
op_relation |
http://europepmc.org/articles/PMC4489764?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0130697 https://doaj.org/article/e7300b630a314bbf908df6725e01f113 |
op_doi |
https://doi.org/10.1371/journal.pone.0130697 |
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PLOS ONE |
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10 |
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7 |
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