Using Agent-Based Modelling to Predict the Role of Wild Refugia in the Evolution of Resistance of Sea Lice to Chemotherapeutants.
A major challenge for Atlantic salmon farming in the northern hemisphere is infestation by the sea louse parasite Lepeophtheirus salmonis. The most frequent method of controlling these sea louse infestations is through the use of chemical treatments. However, most major salmon farming areas have obs...
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ftdoajarticles:oai:doaj.org/article:e712a41cfb8d4db4afbacd5393cc2501 2023-05-15T15:31:35+02:00 Using Agent-Based Modelling to Predict the Role of Wild Refugia in the Evolution of Resistance of Sea Lice to Chemotherapeutants. Gregor F McEwan Maya L Groner Mark D Fast George Gettinby Crawford W Revie 2015-01-01T00:00:00Z https://doi.org/10.1371/journal.pone.0139128 https://doaj.org/article/e712a41cfb8d4db4afbacd5393cc2501 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4618729?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0139128 https://doaj.org/article/e712a41cfb8d4db4afbacd5393cc2501 PLoS ONE, Vol 10, Iss 10, p e0139128 (2015) Medicine R Science Q article 2015 ftdoajarticles https://doi.org/10.1371/journal.pone.0139128 2022-12-31T05:37:29Z A major challenge for Atlantic salmon farming in the northern hemisphere is infestation by the sea louse parasite Lepeophtheirus salmonis. The most frequent method of controlling these sea louse infestations is through the use of chemical treatments. However, most major salmon farming areas have observed resistance to common chemotherapeutants. In terrestrial environments, many strategies employed to manage the evolution of resistance involve the use of refugia, where a portion of the population is left untreated to maintain susceptibility. While refugia have not been deliberately used in Atlantic salmon farming, wild salmon populations that migrate close to salmon farms may act as natural refugia. In this paper we describe an agent-based model that explores the influence of different sizes of wild salmon populations on resistance evolution in sea lice on a salmon farm. Using the model, we demonstrate that wild salmon populations can act as refugia that limit the evolution of resistance in the sea louse populations. Additionally, we demonstrate that an increase in the size of the population of wild salmon results in an increased effect in slowing the evolution of resistance. We explore the effect of a population fitness cost associated with resistance, finding that in some cases it substantially reduces the speed of evolution to chemical treatments. Article in Journal/Newspaper Atlantic salmon Directory of Open Access Journals: DOAJ Articles PLOS ONE 10 10 e0139128 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Medicine R Science Q |
spellingShingle |
Medicine R Science Q Gregor F McEwan Maya L Groner Mark D Fast George Gettinby Crawford W Revie Using Agent-Based Modelling to Predict the Role of Wild Refugia in the Evolution of Resistance of Sea Lice to Chemotherapeutants. |
topic_facet |
Medicine R Science Q |
description |
A major challenge for Atlantic salmon farming in the northern hemisphere is infestation by the sea louse parasite Lepeophtheirus salmonis. The most frequent method of controlling these sea louse infestations is through the use of chemical treatments. However, most major salmon farming areas have observed resistance to common chemotherapeutants. In terrestrial environments, many strategies employed to manage the evolution of resistance involve the use of refugia, where a portion of the population is left untreated to maintain susceptibility. While refugia have not been deliberately used in Atlantic salmon farming, wild salmon populations that migrate close to salmon farms may act as natural refugia. In this paper we describe an agent-based model that explores the influence of different sizes of wild salmon populations on resistance evolution in sea lice on a salmon farm. Using the model, we demonstrate that wild salmon populations can act as refugia that limit the evolution of resistance in the sea louse populations. Additionally, we demonstrate that an increase in the size of the population of wild salmon results in an increased effect in slowing the evolution of resistance. We explore the effect of a population fitness cost associated with resistance, finding that in some cases it substantially reduces the speed of evolution to chemical treatments. |
format |
Article in Journal/Newspaper |
author |
Gregor F McEwan Maya L Groner Mark D Fast George Gettinby Crawford W Revie |
author_facet |
Gregor F McEwan Maya L Groner Mark D Fast George Gettinby Crawford W Revie |
author_sort |
Gregor F McEwan |
title |
Using Agent-Based Modelling to Predict the Role of Wild Refugia in the Evolution of Resistance of Sea Lice to Chemotherapeutants. |
title_short |
Using Agent-Based Modelling to Predict the Role of Wild Refugia in the Evolution of Resistance of Sea Lice to Chemotherapeutants. |
title_full |
Using Agent-Based Modelling to Predict the Role of Wild Refugia in the Evolution of Resistance of Sea Lice to Chemotherapeutants. |
title_fullStr |
Using Agent-Based Modelling to Predict the Role of Wild Refugia in the Evolution of Resistance of Sea Lice to Chemotherapeutants. |
title_full_unstemmed |
Using Agent-Based Modelling to Predict the Role of Wild Refugia in the Evolution of Resistance of Sea Lice to Chemotherapeutants. |
title_sort |
using agent-based modelling to predict the role of wild refugia in the evolution of resistance of sea lice to chemotherapeutants. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2015 |
url |
https://doi.org/10.1371/journal.pone.0139128 https://doaj.org/article/e712a41cfb8d4db4afbacd5393cc2501 |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
PLoS ONE, Vol 10, Iss 10, p e0139128 (2015) |
op_relation |
http://europepmc.org/articles/PMC4618729?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0139128 https://doaj.org/article/e712a41cfb8d4db4afbacd5393cc2501 |
op_doi |
https://doi.org/10.1371/journal.pone.0139128 |
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PLOS ONE |
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10 |
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10 |
container_start_page |
e0139128 |
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1766362098639568896 |