Undiscovered Bat Hosts of Filoviruses.
Ebola and other filoviruses pose significant public health and conservation threats by causing high mortality in primates, including humans. Preventing future outbreaks of ebolavirus depends on identifying wildlife reservoirs, but extraordinarily high biodiversity of potential hosts in temporally dy...
Published in: | PLOS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0004815 https://doaj.org/article/e6fe589ec1b04346a9fce4207469a6bd |
id |
ftdoajarticles:oai:doaj.org/article:e6fe589ec1b04346a9fce4207469a6bd |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:e6fe589ec1b04346a9fce4207469a6bd 2023-05-15T15:08:49+02:00 Undiscovered Bat Hosts of Filoviruses. Barbara A Han John Paul Schmidt Laura W Alexander Sarah E Bowden David T S Hayman John M Drake 2016-07-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0004815 https://doaj.org/article/e6fe589ec1b04346a9fce4207469a6bd EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4945033?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004815 https://doaj.org/article/e6fe589ec1b04346a9fce4207469a6bd PLoS Neglected Tropical Diseases, Vol 10, Iss 7, p e0004815 (2016) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2016 ftdoajarticles https://doi.org/10.1371/journal.pntd.0004815 2022-12-31T01:09:27Z Ebola and other filoviruses pose significant public health and conservation threats by causing high mortality in primates, including humans. Preventing future outbreaks of ebolavirus depends on identifying wildlife reservoirs, but extraordinarily high biodiversity of potential hosts in temporally dynamic environments of equatorial Africa contributes to sporadic, unpredictable outbreaks that have hampered efforts to identify wild reservoirs for nearly 40 years. Using a machine learning algorithm, generalized boosted regression, we characterize potential filovirus-positive bat species with estimated 87% accuracy. Our model produces two specific outputs with immediate utility for guiding filovirus surveillance in the wild. First, we report a profile of intrinsic traits that discriminates hosts from non-hosts, providing a biological caricature of a filovirus-positive bat species. This profile emphasizes traits describing adult and neonate body sizes and rates of reproductive fitness, as well as species' geographic range overlap with regions of high mammalian diversity. Second, we identify several bat species ranked most likely to be filovirus-positive on the basis of intrinsic trait similarity with known filovirus-positive bats. New bat species predicted to be positive for filoviruses are widely distributed outside of equatorial Africa, with a majority of species overlapping in Southeast Asia. Taken together, these results spotlight several potential host species and geographical regions as high-probability targets for future filovirus surveillance. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 10 7 e0004815 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Barbara A Han John Paul Schmidt Laura W Alexander Sarah E Bowden David T S Hayman John M Drake Undiscovered Bat Hosts of Filoviruses. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Ebola and other filoviruses pose significant public health and conservation threats by causing high mortality in primates, including humans. Preventing future outbreaks of ebolavirus depends on identifying wildlife reservoirs, but extraordinarily high biodiversity of potential hosts in temporally dynamic environments of equatorial Africa contributes to sporadic, unpredictable outbreaks that have hampered efforts to identify wild reservoirs for nearly 40 years. Using a machine learning algorithm, generalized boosted regression, we characterize potential filovirus-positive bat species with estimated 87% accuracy. Our model produces two specific outputs with immediate utility for guiding filovirus surveillance in the wild. First, we report a profile of intrinsic traits that discriminates hosts from non-hosts, providing a biological caricature of a filovirus-positive bat species. This profile emphasizes traits describing adult and neonate body sizes and rates of reproductive fitness, as well as species' geographic range overlap with regions of high mammalian diversity. Second, we identify several bat species ranked most likely to be filovirus-positive on the basis of intrinsic trait similarity with known filovirus-positive bats. New bat species predicted to be positive for filoviruses are widely distributed outside of equatorial Africa, with a majority of species overlapping in Southeast Asia. Taken together, these results spotlight several potential host species and geographical regions as high-probability targets for future filovirus surveillance. |
format |
Article in Journal/Newspaper |
author |
Barbara A Han John Paul Schmidt Laura W Alexander Sarah E Bowden David T S Hayman John M Drake |
author_facet |
Barbara A Han John Paul Schmidt Laura W Alexander Sarah E Bowden David T S Hayman John M Drake |
author_sort |
Barbara A Han |
title |
Undiscovered Bat Hosts of Filoviruses. |
title_short |
Undiscovered Bat Hosts of Filoviruses. |
title_full |
Undiscovered Bat Hosts of Filoviruses. |
title_fullStr |
Undiscovered Bat Hosts of Filoviruses. |
title_full_unstemmed |
Undiscovered Bat Hosts of Filoviruses. |
title_sort |
undiscovered bat hosts of filoviruses. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pntd.0004815 https://doaj.org/article/e6fe589ec1b04346a9fce4207469a6bd |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 10, Iss 7, p e0004815 (2016) |
op_relation |
http://europepmc.org/articles/PMC4945033?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004815 https://doaj.org/article/e6fe589ec1b04346a9fce4207469a6bd |
op_doi |
https://doi.org/10.1371/journal.pntd.0004815 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
10 |
container_issue |
7 |
container_start_page |
e0004815 |
_version_ |
1766340101876482048 |