Assessing the impact of the addition of pyriproxyfen on the durability of permethrin-treated bed nets in Burkina Faso: a compound-randomized controlled trial
Abstract Background Long-lasting insecticidal nets (LLINs) treated with pyrethroids are the foundation of malaria control in sub-Saharan Africa. Rising pyrethroid resistance in vectors, however, has driven the development of alternative net formulations. Here the durability of polyethylene nets with...
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ftdoajarticles:oai:doaj.org/article:e6dc631680a44098820830b121d0e078 2023-05-15T15:17:18+02:00 Assessing the impact of the addition of pyriproxyfen on the durability of permethrin-treated bed nets in Burkina Faso: a compound-randomized controlled trial Kobié H. Toé Frank Mechan Julie-Anne A. Tangena Marion Morris Joanna Solino Emile F. S. Tchicaya Alphonse Traoré Hanafy Ismail James Maas Natalie Lissenden Margaret Pinder Steve W. Lindsay Alfred B. Tiono Hilary Ranson N’Falé Sagnon 2019-12-01T00:00:00Z https://doi.org/10.1186/s12936-019-3018-1 https://doaj.org/article/e6dc631680a44098820830b121d0e078 EN eng BMC https://doi.org/10.1186/s12936-019-3018-1 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-3018-1 1475-2875 https://doaj.org/article/e6dc631680a44098820830b121d0e078 Malaria Journal, Vol 18, Iss 1, Pp 1-16 (2019) Anopheles gambiae Burkina Faso Long-lasting insecticidal nets Malaria control Net durability Olyset Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2019 ftdoajarticles https://doi.org/10.1186/s12936-019-3018-1 2022-12-31T06:42:26Z Abstract Background Long-lasting insecticidal nets (LLINs) treated with pyrethroids are the foundation of malaria control in sub-Saharan Africa. Rising pyrethroid resistance in vectors, however, has driven the development of alternative net formulations. Here the durability of polyethylene nets with a novel combination of a pyrethroid, permethrin, and the insect juvenile hormone mimic, pyriproxyfen (PPF), compared to a standard permethrin LLIN, was assessed in rural Burkina Faso. Methods A compound-randomized controlled trial was completed in two villages. In one village 326 of the PPF-permethrin nets (Olyset Duo) and 327 standard LLINs (Olyset) were distributed to assess bioefficacy. In a second village, 170 PPF-permethrin nets and 376 LLINs were distributed to assess survivorship. Nets were followed at 6-monthly intervals for 3 years. Bioefficacy was assessed by exposing permethrin-susceptible and resistant Anopheles gambiae sensu lato mosquito strains to standard World Health Organization (WHO) cone and tunnel tests with impacts on fertility measured in the resistant strain. Insecticide content was measured using high-performance liquid chromatography. LLIN survivorship was recorded with a questionnaire and assessed by comparing the physical integrity using the proportionate hole index (pHI). Results The PPF-permethrin net met WHO bioefficacy criteria (≥ 80% mortality or ≥ 95% knockdown) for the first 18 months, compared to 6 months for the standard LLIN. Mean mosquito mortality for PPF-permethrin nets, across all time points, was 8.6% (CI 2.6–14.6%) higher than the standard LLIN. Fertility rates were reduced after PPF-permethrin net exposure at 1-month post distribution, but not later. Permethrin content of both types of nets remained within the target range of 20 g/kg ± 25% for 242/248 nets tested. The pyriproxyfen content of PPF-permethrin nets declined by 54%, from 10.4 g/kg (CI 10.2–10.6) to 4.7 g/kg (CI 3.5–6.0, p < 0.001) over 36 months. Net survivorship was poor, with only 13% of PPF-permethrin ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 18 1 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Anopheles gambiae Burkina Faso Long-lasting insecticidal nets Malaria control Net durability Olyset Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Anopheles gambiae Burkina Faso Long-lasting insecticidal nets Malaria control Net durability Olyset Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Kobié H. Toé Frank Mechan Julie-Anne A. Tangena Marion Morris Joanna Solino Emile F. S. Tchicaya Alphonse Traoré Hanafy Ismail James Maas Natalie Lissenden Margaret Pinder Steve W. Lindsay Alfred B. Tiono Hilary Ranson N’Falé Sagnon Assessing the impact of the addition of pyriproxyfen on the durability of permethrin-treated bed nets in Burkina Faso: a compound-randomized controlled trial |
topic_facet |
Anopheles gambiae Burkina Faso Long-lasting insecticidal nets Malaria control Net durability Olyset Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Long-lasting insecticidal nets (LLINs) treated with pyrethroids are the foundation of malaria control in sub-Saharan Africa. Rising pyrethroid resistance in vectors, however, has driven the development of alternative net formulations. Here the durability of polyethylene nets with a novel combination of a pyrethroid, permethrin, and the insect juvenile hormone mimic, pyriproxyfen (PPF), compared to a standard permethrin LLIN, was assessed in rural Burkina Faso. Methods A compound-randomized controlled trial was completed in two villages. In one village 326 of the PPF-permethrin nets (Olyset Duo) and 327 standard LLINs (Olyset) were distributed to assess bioefficacy. In a second village, 170 PPF-permethrin nets and 376 LLINs were distributed to assess survivorship. Nets were followed at 6-monthly intervals for 3 years. Bioefficacy was assessed by exposing permethrin-susceptible and resistant Anopheles gambiae sensu lato mosquito strains to standard World Health Organization (WHO) cone and tunnel tests with impacts on fertility measured in the resistant strain. Insecticide content was measured using high-performance liquid chromatography. LLIN survivorship was recorded with a questionnaire and assessed by comparing the physical integrity using the proportionate hole index (pHI). Results The PPF-permethrin net met WHO bioefficacy criteria (≥ 80% mortality or ≥ 95% knockdown) for the first 18 months, compared to 6 months for the standard LLIN. Mean mosquito mortality for PPF-permethrin nets, across all time points, was 8.6% (CI 2.6–14.6%) higher than the standard LLIN. Fertility rates were reduced after PPF-permethrin net exposure at 1-month post distribution, but not later. Permethrin content of both types of nets remained within the target range of 20 g/kg ± 25% for 242/248 nets tested. The pyriproxyfen content of PPF-permethrin nets declined by 54%, from 10.4 g/kg (CI 10.2–10.6) to 4.7 g/kg (CI 3.5–6.0, p < 0.001) over 36 months. Net survivorship was poor, with only 13% of PPF-permethrin ... |
format |
Article in Journal/Newspaper |
author |
Kobié H. Toé Frank Mechan Julie-Anne A. Tangena Marion Morris Joanna Solino Emile F. S. Tchicaya Alphonse Traoré Hanafy Ismail James Maas Natalie Lissenden Margaret Pinder Steve W. Lindsay Alfred B. Tiono Hilary Ranson N’Falé Sagnon |
author_facet |
Kobié H. Toé Frank Mechan Julie-Anne A. Tangena Marion Morris Joanna Solino Emile F. S. Tchicaya Alphonse Traoré Hanafy Ismail James Maas Natalie Lissenden Margaret Pinder Steve W. Lindsay Alfred B. Tiono Hilary Ranson N’Falé Sagnon |
author_sort |
Kobié H. Toé |
title |
Assessing the impact of the addition of pyriproxyfen on the durability of permethrin-treated bed nets in Burkina Faso: a compound-randomized controlled trial |
title_short |
Assessing the impact of the addition of pyriproxyfen on the durability of permethrin-treated bed nets in Burkina Faso: a compound-randomized controlled trial |
title_full |
Assessing the impact of the addition of pyriproxyfen on the durability of permethrin-treated bed nets in Burkina Faso: a compound-randomized controlled trial |
title_fullStr |
Assessing the impact of the addition of pyriproxyfen on the durability of permethrin-treated bed nets in Burkina Faso: a compound-randomized controlled trial |
title_full_unstemmed |
Assessing the impact of the addition of pyriproxyfen on the durability of permethrin-treated bed nets in Burkina Faso: a compound-randomized controlled trial |
title_sort |
assessing the impact of the addition of pyriproxyfen on the durability of permethrin-treated bed nets in burkina faso: a compound-randomized controlled trial |
publisher |
BMC |
publishDate |
2019 |
url |
https://doi.org/10.1186/s12936-019-3018-1 https://doaj.org/article/e6dc631680a44098820830b121d0e078 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 18, Iss 1, Pp 1-16 (2019) |
op_relation |
https://doi.org/10.1186/s12936-019-3018-1 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-3018-1 1475-2875 https://doaj.org/article/e6dc631680a44098820830b121d0e078 |
op_doi |
https://doi.org/10.1186/s12936-019-3018-1 |
container_title |
Malaria Journal |
container_volume |
18 |
container_issue |
1 |
_version_ |
1766347560122843136 |