Tularemia induces different biochemical responses in BALB/c mice and common voles
Abstract Background Both BALB/c mice and common voles ( Microtus arvalis ) are considered highly susceptible to tularemia. However, the common vole is reported to harbour Francisella tularensis in European habitats as well as to survive longer with chronic shedding of the bacterium. The purpose of t...
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ftdoajarticles:oai:doaj.org/article:e6d6ea04606a4c7281973d52b34e6957 2023-05-15T15:56:37+02:00 Tularemia induces different biochemical responses in BALB/c mice and common voles Vitula Frantisek Treml Frantisek Hubalek Martin Novotny Ladislav Pohanka Miroslav Sedlackova Jana Bandouchova Hana Pikula Jiri 2009-06-01T00:00:00Z https://doi.org/10.1186/1471-2334-9-101 https://doaj.org/article/e6d6ea04606a4c7281973d52b34e6957 EN eng BMC http://www.biomedcentral.com/1471-2334/9/101 https://doaj.org/toc/1471-2334 doi:10.1186/1471-2334-9-101 1471-2334 https://doaj.org/article/e6d6ea04606a4c7281973d52b34e6957 BMC Infectious Diseases, Vol 9, Iss 1, p 101 (2009) Infectious and parasitic diseases RC109-216 article 2009 ftdoajarticles https://doi.org/10.1186/1471-2334-9-101 2022-12-30T23:36:54Z Abstract Background Both BALB/c mice and common voles ( Microtus arvalis ) are considered highly susceptible to tularemia. However, the common vole is reported to harbour Francisella tularensis in European habitats as well as to survive longer with chronic shedding of the bacterium. The purpose of the present study was to compare the response of these two rodents to a wild Francisella tularensis subsp. holarctica strain infection. Methods Rodents were evaluated for differences in the total antioxidant capacity derived from low-molecular-weight antioxidants, biochemistry including lipid metabolism, tissue bacterial burdens and histopathology following experimental intraperitoneal infection with 160 colony forming units (CFU) pro toto . Results Bacterial burdens in common voles started to develop later post-exposure and amounted to lower levels than in BALB/c mice. Elevation of liver function enzymes was more pronounced in mice than common voles and there were marked differences in lipid metabolism in the course of tularemia in these two species. Hypertriglyceridemia and hypercholesterolemia developed in mice, while physiologically higher levels of triglycerides and cholesterol showed a decreasing tendency in common voles. On the other hand, the total plasma antioxidant capacity gradually dropped to 81.5% in mice on day 5 post-infection, while it increased to 130% on day 6 post-infection in common voles. Significant correlations between tissue bacterial burdens and several biochemical parameters were found. Conclusion As differences in lipid metabolism and the total antioxidant capacity of highly susceptible rodent species were demonstrated, the role of triglycerides, cholesterol and antioxidants in tularemic sepsis should be further investigated. Article in Journal/Newspaper Common vole Microtus arvalis Directory of Open Access Journals: DOAJ Articles BMC Infectious Diseases 9 1 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
topic |
Infectious and parasitic diseases RC109-216 |
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Infectious and parasitic diseases RC109-216 Vitula Frantisek Treml Frantisek Hubalek Martin Novotny Ladislav Pohanka Miroslav Sedlackova Jana Bandouchova Hana Pikula Jiri Tularemia induces different biochemical responses in BALB/c mice and common voles |
topic_facet |
Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Both BALB/c mice and common voles ( Microtus arvalis ) are considered highly susceptible to tularemia. However, the common vole is reported to harbour Francisella tularensis in European habitats as well as to survive longer with chronic shedding of the bacterium. The purpose of the present study was to compare the response of these two rodents to a wild Francisella tularensis subsp. holarctica strain infection. Methods Rodents were evaluated for differences in the total antioxidant capacity derived from low-molecular-weight antioxidants, biochemistry including lipid metabolism, tissue bacterial burdens and histopathology following experimental intraperitoneal infection with 160 colony forming units (CFU) pro toto . Results Bacterial burdens in common voles started to develop later post-exposure and amounted to lower levels than in BALB/c mice. Elevation of liver function enzymes was more pronounced in mice than common voles and there were marked differences in lipid metabolism in the course of tularemia in these two species. Hypertriglyceridemia and hypercholesterolemia developed in mice, while physiologically higher levels of triglycerides and cholesterol showed a decreasing tendency in common voles. On the other hand, the total plasma antioxidant capacity gradually dropped to 81.5% in mice on day 5 post-infection, while it increased to 130% on day 6 post-infection in common voles. Significant correlations between tissue bacterial burdens and several biochemical parameters were found. Conclusion As differences in lipid metabolism and the total antioxidant capacity of highly susceptible rodent species were demonstrated, the role of triglycerides, cholesterol and antioxidants in tularemic sepsis should be further investigated. |
format |
Article in Journal/Newspaper |
author |
Vitula Frantisek Treml Frantisek Hubalek Martin Novotny Ladislav Pohanka Miroslav Sedlackova Jana Bandouchova Hana Pikula Jiri |
author_facet |
Vitula Frantisek Treml Frantisek Hubalek Martin Novotny Ladislav Pohanka Miroslav Sedlackova Jana Bandouchova Hana Pikula Jiri |
author_sort |
Vitula Frantisek |
title |
Tularemia induces different biochemical responses in BALB/c mice and common voles |
title_short |
Tularemia induces different biochemical responses in BALB/c mice and common voles |
title_full |
Tularemia induces different biochemical responses in BALB/c mice and common voles |
title_fullStr |
Tularemia induces different biochemical responses in BALB/c mice and common voles |
title_full_unstemmed |
Tularemia induces different biochemical responses in BALB/c mice and common voles |
title_sort |
tularemia induces different biochemical responses in balb/c mice and common voles |
publisher |
BMC |
publishDate |
2009 |
url |
https://doi.org/10.1186/1471-2334-9-101 https://doaj.org/article/e6d6ea04606a4c7281973d52b34e6957 |
genre |
Common vole Microtus arvalis |
genre_facet |
Common vole Microtus arvalis |
op_source |
BMC Infectious Diseases, Vol 9, Iss 1, p 101 (2009) |
op_relation |
http://www.biomedcentral.com/1471-2334/9/101 https://doaj.org/toc/1471-2334 doi:10.1186/1471-2334-9-101 1471-2334 https://doaj.org/article/e6d6ea04606a4c7281973d52b34e6957 |
op_doi |
https://doi.org/10.1186/1471-2334-9-101 |
container_title |
BMC Infectious Diseases |
container_volume |
9 |
container_issue |
1 |
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1766392016014409728 |