Effectiveness of lipid-lowering therapy among a sample of patients in Colombia
OBJECTIVE: To determine the effectiveness of lipid-lowering therapy in a sample of patients affiliated with the Sistema General de Seguridad Social en Salud (the Colombian health system). METHODS: A cross-sectional study was conducted from 1 January 2010-30 June 2011. From a total of 8 316 patients...
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ftdoajarticles:oai:doaj.org/article:e6bf563d92f143be8873b853434497e7 2023-05-15T15:12:14+02:00 Effectiveness of lipid-lowering therapy among a sample of patients in Colombia Jorge Enrique Machado-Alba Maria Monica Murillo-Muñoz Manuel Enrique Machado-Duque 2013-06-01T00:00:00Z https://doaj.org/article/e6bf563d92f143be8873b853434497e7 EN ES PT eng spa por Pan American Health Organization http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892013000600001&lng=en&tlng=en https://doaj.org/toc/1020-4989 1020-4989 https://doaj.org/article/e6bf563d92f143be8873b853434497e7 Revista Panamericana de Salud Pública, Vol 33, Iss 6, Pp 383-390 (2013) Dislipidemias anticolesterolemiantes enfermedades cardiovasculares lovastatina gemfibrozilo Colombia Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2013 ftdoajarticles 2022-12-30T22:36:03Z OBJECTIVE: To determine the effectiveness of lipid-lowering therapy in a sample of patients affiliated with the Sistema General de Seguridad Social en Salud (the Colombian health system). METHODS: A cross-sectional study was conducted from 1 January 2010-30 June 2011. From a total of 8 316 patients in 10 cities, a random sample of 600 was stratified according to dyslipidemia. Information on sociodemographic and anthropometric characteristics, risk factors, and pharmacological and laboratory variables were obtained from medical records. RESULTS: Subjects were predominantly female (56.2%), with a mean age of 65.1 ± 11.5 years; 93.2% had hypertension; 29.0%, diabetes mellitus; and 10.2%, a history of myocardial infarction. The patients were being treated with lovastatin (84.1%) or gemfibrozil (12.3%)-both at doses below what is recommended-or atorvastatin (1.8%). In patients with high cardiovascular risk, 38.6% achieved goals for low-density lipoprotein cholesterol (LDL-C) levels (<100 mg/dL). Among those at moderate risk, 49.4% reached the target level (< 130 mg/dL). On average, there was a 4.9% reduction in LDL-C. Sex, age, history of cardiovascular disease and/or diabetes mellitus, use of hydrochlorothiazide, and poor therapy adherence were statistically associated with a lack of dyslipidemia control. CONCLUSIONS: Because a lack LDL-C control occurred in patients with two or more of the following variables: male, more than 55 years of age, diabetes and/or a history of cardiovascular disease, received lower doses of lovastatin, or non-adherent to treatment, it is recommended that medication be increased based on clearly-defined therapeutic goals and that comorbidities be assessed and effectively treated. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English Spanish Portuguese |
topic |
Dislipidemias anticolesterolemiantes enfermedades cardiovasculares lovastatina gemfibrozilo Colombia Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Dislipidemias anticolesterolemiantes enfermedades cardiovasculares lovastatina gemfibrozilo Colombia Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Jorge Enrique Machado-Alba Maria Monica Murillo-Muñoz Manuel Enrique Machado-Duque Effectiveness of lipid-lowering therapy among a sample of patients in Colombia |
topic_facet |
Dislipidemias anticolesterolemiantes enfermedades cardiovasculares lovastatina gemfibrozilo Colombia Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
OBJECTIVE: To determine the effectiveness of lipid-lowering therapy in a sample of patients affiliated with the Sistema General de Seguridad Social en Salud (the Colombian health system). METHODS: A cross-sectional study was conducted from 1 January 2010-30 June 2011. From a total of 8 316 patients in 10 cities, a random sample of 600 was stratified according to dyslipidemia. Information on sociodemographic and anthropometric characteristics, risk factors, and pharmacological and laboratory variables were obtained from medical records. RESULTS: Subjects were predominantly female (56.2%), with a mean age of 65.1 ± 11.5 years; 93.2% had hypertension; 29.0%, diabetes mellitus; and 10.2%, a history of myocardial infarction. The patients were being treated with lovastatin (84.1%) or gemfibrozil (12.3%)-both at doses below what is recommended-or atorvastatin (1.8%). In patients with high cardiovascular risk, 38.6% achieved goals for low-density lipoprotein cholesterol (LDL-C) levels (<100 mg/dL). Among those at moderate risk, 49.4% reached the target level (< 130 mg/dL). On average, there was a 4.9% reduction in LDL-C. Sex, age, history of cardiovascular disease and/or diabetes mellitus, use of hydrochlorothiazide, and poor therapy adherence were statistically associated with a lack of dyslipidemia control. CONCLUSIONS: Because a lack LDL-C control occurred in patients with two or more of the following variables: male, more than 55 years of age, diabetes and/or a history of cardiovascular disease, received lower doses of lovastatin, or non-adherent to treatment, it is recommended that medication be increased based on clearly-defined therapeutic goals and that comorbidities be assessed and effectively treated. |
format |
Article in Journal/Newspaper |
author |
Jorge Enrique Machado-Alba Maria Monica Murillo-Muñoz Manuel Enrique Machado-Duque |
author_facet |
Jorge Enrique Machado-Alba Maria Monica Murillo-Muñoz Manuel Enrique Machado-Duque |
author_sort |
Jorge Enrique Machado-Alba |
title |
Effectiveness of lipid-lowering therapy among a sample of patients in Colombia |
title_short |
Effectiveness of lipid-lowering therapy among a sample of patients in Colombia |
title_full |
Effectiveness of lipid-lowering therapy among a sample of patients in Colombia |
title_fullStr |
Effectiveness of lipid-lowering therapy among a sample of patients in Colombia |
title_full_unstemmed |
Effectiveness of lipid-lowering therapy among a sample of patients in Colombia |
title_sort |
effectiveness of lipid-lowering therapy among a sample of patients in colombia |
publisher |
Pan American Health Organization |
publishDate |
2013 |
url |
https://doaj.org/article/e6bf563d92f143be8873b853434497e7 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista Panamericana de Salud Pública, Vol 33, Iss 6, Pp 383-390 (2013) |
op_relation |
http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892013000600001&lng=en&tlng=en https://doaj.org/toc/1020-4989 1020-4989 https://doaj.org/article/e6bf563d92f143be8873b853434497e7 |
_version_ |
1766342940347596800 |