Challenges and lessons learned from the rapid operationalization of a prospective cohort to study the natural history and neurodevelopmental outcomes of postnatal Zika virus infection among infants and children in rural Guatemala.
During the course of the 2015-2017 outbreak of Zika virus (ZIKV) in the Americas, the emerging virus was recognized as a congenital infection that could damage the developing brain. As the Latin American ZIKV outbreak advanced, the scientific and public health community questioned if this newly reco...
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ftdoajarticles:oai:doaj.org/article:e684d229eef4414f8513ebc93aa75477 2023-05-15T15:07:48+02:00 Challenges and lessons learned from the rapid operationalization of a prospective cohort to study the natural history and neurodevelopmental outcomes of postnatal Zika virus infection among infants and children in rural Guatemala. Alejandra Paniagua-Avila Daniel Olson Amy Connery D Mirella Calvimontes Guillermo A Bolanos Molly M Lamb Desiree Bauer Aida Ralda Neudy Rojop Eduardo Barrios Andrea Chacon Melissa Gomez Paola Arroyave Sara Hernandez Maria Alejandra Martinez Saskia Bunge-Montes Alison Colbert Kareen Arias Garret Brazeale Andrea Holliday Kay M Tomashek Hana M El Sahly Wendy Keitel Flor M Munoz Edwin J Asturias 2022-11-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0010480 https://doaj.org/article/e684d229eef4414f8513ebc93aa75477 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0010480 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010480 https://doaj.org/article/e684d229eef4414f8513ebc93aa75477 PLoS Neglected Tropical Diseases, Vol 16, Iss 11, p e0010480 (2022) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2022 ftdoajarticles https://doi.org/10.1371/journal.pntd.0010480 2022-12-30T19:35:03Z During the course of the 2015-2017 outbreak of Zika virus (ZIKV) in the Americas, the emerging virus was recognized as a congenital infection that could damage the developing brain. As the Latin American ZIKV outbreak advanced, the scientific and public health community questioned if this newly recognized neurotropic flavivirus could affect the developing brain of infants and young children infected after birth. We report here the study design, methods and the challenges and lessons learned from the rapid operationalization of a prospective natural history cohort study aimed at evaluating the potential neurological and neurodevelopmental effects of postnatal ZIKV infection in infants and young children, which had become epidemic in Central America. This study enrolled a cohort of 500 mothers and their infants, along with nearly 400 children 1.5-3.5 years of age who were born during the initial phase of the ZIKV epidemic in a rural area of Guatemala. Our solutions and lessons learned while tackling real-life challenges may serve as a guide to other researchers carrying out studies of emerging infectious diseases of public health priority in resource-constrained settings. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 16 11 e0010480 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Alejandra Paniagua-Avila Daniel Olson Amy Connery D Mirella Calvimontes Guillermo A Bolanos Molly M Lamb Desiree Bauer Aida Ralda Neudy Rojop Eduardo Barrios Andrea Chacon Melissa Gomez Paola Arroyave Sara Hernandez Maria Alejandra Martinez Saskia Bunge-Montes Alison Colbert Kareen Arias Garret Brazeale Andrea Holliday Kay M Tomashek Hana M El Sahly Wendy Keitel Flor M Munoz Edwin J Asturias Challenges and lessons learned from the rapid operationalization of a prospective cohort to study the natural history and neurodevelopmental outcomes of postnatal Zika virus infection among infants and children in rural Guatemala. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
During the course of the 2015-2017 outbreak of Zika virus (ZIKV) in the Americas, the emerging virus was recognized as a congenital infection that could damage the developing brain. As the Latin American ZIKV outbreak advanced, the scientific and public health community questioned if this newly recognized neurotropic flavivirus could affect the developing brain of infants and young children infected after birth. We report here the study design, methods and the challenges and lessons learned from the rapid operationalization of a prospective natural history cohort study aimed at evaluating the potential neurological and neurodevelopmental effects of postnatal ZIKV infection in infants and young children, which had become epidemic in Central America. This study enrolled a cohort of 500 mothers and their infants, along with nearly 400 children 1.5-3.5 years of age who were born during the initial phase of the ZIKV epidemic in a rural area of Guatemala. Our solutions and lessons learned while tackling real-life challenges may serve as a guide to other researchers carrying out studies of emerging infectious diseases of public health priority in resource-constrained settings. |
format |
Article in Journal/Newspaper |
author |
Alejandra Paniagua-Avila Daniel Olson Amy Connery D Mirella Calvimontes Guillermo A Bolanos Molly M Lamb Desiree Bauer Aida Ralda Neudy Rojop Eduardo Barrios Andrea Chacon Melissa Gomez Paola Arroyave Sara Hernandez Maria Alejandra Martinez Saskia Bunge-Montes Alison Colbert Kareen Arias Garret Brazeale Andrea Holliday Kay M Tomashek Hana M El Sahly Wendy Keitel Flor M Munoz Edwin J Asturias |
author_facet |
Alejandra Paniagua-Avila Daniel Olson Amy Connery D Mirella Calvimontes Guillermo A Bolanos Molly M Lamb Desiree Bauer Aida Ralda Neudy Rojop Eduardo Barrios Andrea Chacon Melissa Gomez Paola Arroyave Sara Hernandez Maria Alejandra Martinez Saskia Bunge-Montes Alison Colbert Kareen Arias Garret Brazeale Andrea Holliday Kay M Tomashek Hana M El Sahly Wendy Keitel Flor M Munoz Edwin J Asturias |
author_sort |
Alejandra Paniagua-Avila |
title |
Challenges and lessons learned from the rapid operationalization of a prospective cohort to study the natural history and neurodevelopmental outcomes of postnatal Zika virus infection among infants and children in rural Guatemala. |
title_short |
Challenges and lessons learned from the rapid operationalization of a prospective cohort to study the natural history and neurodevelopmental outcomes of postnatal Zika virus infection among infants and children in rural Guatemala. |
title_full |
Challenges and lessons learned from the rapid operationalization of a prospective cohort to study the natural history and neurodevelopmental outcomes of postnatal Zika virus infection among infants and children in rural Guatemala. |
title_fullStr |
Challenges and lessons learned from the rapid operationalization of a prospective cohort to study the natural history and neurodevelopmental outcomes of postnatal Zika virus infection among infants and children in rural Guatemala. |
title_full_unstemmed |
Challenges and lessons learned from the rapid operationalization of a prospective cohort to study the natural history and neurodevelopmental outcomes of postnatal Zika virus infection among infants and children in rural Guatemala. |
title_sort |
challenges and lessons learned from the rapid operationalization of a prospective cohort to study the natural history and neurodevelopmental outcomes of postnatal zika virus infection among infants and children in rural guatemala. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2022 |
url |
https://doi.org/10.1371/journal.pntd.0010480 https://doaj.org/article/e684d229eef4414f8513ebc93aa75477 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 16, Iss 11, p e0010480 (2022) |
op_relation |
https://doi.org/10.1371/journal.pntd.0010480 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010480 https://doaj.org/article/e684d229eef4414f8513ebc93aa75477 |
op_doi |
https://doi.org/10.1371/journal.pntd.0010480 |
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PLOS Neglected Tropical Diseases |
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16 |
container_issue |
11 |
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e0010480 |
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1766339218339004416 |