Auditory assessment of patients with acute uncomplicated Plasmodium falciparum malaria treated with three-day mefloquine-artesunate on the north-western border of Thailand
Abstract Background The use of artemisinin derivatives has increased exponentially with the deployment of artemisinin combination therapy (ACT) in all malarious areas. They are highly effective and are considered safe, but in animal studies artemisinin derivatives produce neurotoxicity targeting mai...
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ftdoajarticles:oai:doaj.org/article:e607d6808b6e40b9b45660f337c15c32 2023-05-15T15:09:18+02:00 Auditory assessment of patients with acute uncomplicated Plasmodium falciparum malaria treated with three-day mefloquine-artesunate on the north-western border of Thailand Arunkamomkiri Jaruwan Htoo Hsar Soe Ma Nwee Paw Phyo Aung P Carrara Verena I Singhasivanon Pratap Nosten François 2008-11-01T00:00:00Z https://doi.org/10.1186/1475-2875-7-233 https://doaj.org/article/e607d6808b6e40b9b45660f337c15c32 EN eng BMC http://www.malariajournal.com/content/7/1/233 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-7-233 1475-2875 https://doaj.org/article/e607d6808b6e40b9b45660f337c15c32 Malaria Journal, Vol 7, Iss 1, p 233 (2008) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2008 ftdoajarticles https://doi.org/10.1186/1475-2875-7-233 2022-12-31T08:13:33Z Abstract Background The use of artemisinin derivatives has increased exponentially with the deployment of artemisinin combination therapy (ACT) in all malarious areas. They are highly effective and are considered safe, but in animal studies artemisinin derivatives produce neurotoxicity targeting mainly the auditory and vestibular pathways. The debate remains as to whether artemisinin derivatives induce similar toxicity in humans. Methods This prospective study assessed the effects on auditory function of a standard 3-day oral dose of artesunate (4 mg/kg/day) combined with mefloquine (25 mg/kg) in patients with acute uncomplicated falciparum malaria treated at the Shoklo Malaria Research Unit, on the Thai-Burmese border. A complete auditory evaluation with tympanometry, audiometry and auditory brainstem responses (ABR) was performed before the first dose and seven days after initiation of the antimalarial treatment. Results Complete auditory tests at day 0 (D0) and day 7 (D7) were obtained for 93 patients. Hearing loss (threshold > 25 dB) on admission was common (57%) and associated with age only. No patient had a threshold change exceeding 10 dB between D0 and D7 at any tested frequency. No patient showed a shift in Wave III peak latency of more than 0.30 msec between baseline and D7. Conclusion Neither audiometric or the ABR tests showed clinical evidence of auditory toxicity seven days after receiving oral artesunate and mefloquine. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 7 1 233 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Arunkamomkiri Jaruwan Htoo Hsar Soe Ma Nwee Paw Phyo Aung P Carrara Verena I Singhasivanon Pratap Nosten François Auditory assessment of patients with acute uncomplicated Plasmodium falciparum malaria treated with three-day mefloquine-artesunate on the north-western border of Thailand |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background The use of artemisinin derivatives has increased exponentially with the deployment of artemisinin combination therapy (ACT) in all malarious areas. They are highly effective and are considered safe, but in animal studies artemisinin derivatives produce neurotoxicity targeting mainly the auditory and vestibular pathways. The debate remains as to whether artemisinin derivatives induce similar toxicity in humans. Methods This prospective study assessed the effects on auditory function of a standard 3-day oral dose of artesunate (4 mg/kg/day) combined with mefloquine (25 mg/kg) in patients with acute uncomplicated falciparum malaria treated at the Shoklo Malaria Research Unit, on the Thai-Burmese border. A complete auditory evaluation with tympanometry, audiometry and auditory brainstem responses (ABR) was performed before the first dose and seven days after initiation of the antimalarial treatment. Results Complete auditory tests at day 0 (D0) and day 7 (D7) were obtained for 93 patients. Hearing loss (threshold > 25 dB) on admission was common (57%) and associated with age only. No patient had a threshold change exceeding 10 dB between D0 and D7 at any tested frequency. No patient showed a shift in Wave III peak latency of more than 0.30 msec between baseline and D7. Conclusion Neither audiometric or the ABR tests showed clinical evidence of auditory toxicity seven days after receiving oral artesunate and mefloquine. |
format |
Article in Journal/Newspaper |
author |
Arunkamomkiri Jaruwan Htoo Hsar Soe Ma Nwee Paw Phyo Aung P Carrara Verena I Singhasivanon Pratap Nosten François |
author_facet |
Arunkamomkiri Jaruwan Htoo Hsar Soe Ma Nwee Paw Phyo Aung P Carrara Verena I Singhasivanon Pratap Nosten François |
author_sort |
Arunkamomkiri Jaruwan |
title |
Auditory assessment of patients with acute uncomplicated Plasmodium falciparum malaria treated with three-day mefloquine-artesunate on the north-western border of Thailand |
title_short |
Auditory assessment of patients with acute uncomplicated Plasmodium falciparum malaria treated with three-day mefloquine-artesunate on the north-western border of Thailand |
title_full |
Auditory assessment of patients with acute uncomplicated Plasmodium falciparum malaria treated with three-day mefloquine-artesunate on the north-western border of Thailand |
title_fullStr |
Auditory assessment of patients with acute uncomplicated Plasmodium falciparum malaria treated with three-day mefloquine-artesunate on the north-western border of Thailand |
title_full_unstemmed |
Auditory assessment of patients with acute uncomplicated Plasmodium falciparum malaria treated with three-day mefloquine-artesunate on the north-western border of Thailand |
title_sort |
auditory assessment of patients with acute uncomplicated plasmodium falciparum malaria treated with three-day mefloquine-artesunate on the north-western border of thailand |
publisher |
BMC |
publishDate |
2008 |
url |
https://doi.org/10.1186/1475-2875-7-233 https://doaj.org/article/e607d6808b6e40b9b45660f337c15c32 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 7, Iss 1, p 233 (2008) |
op_relation |
http://www.malariajournal.com/content/7/1/233 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-7-233 1475-2875 https://doaj.org/article/e607d6808b6e40b9b45660f337c15c32 |
op_doi |
https://doi.org/10.1186/1475-2875-7-233 |
container_title |
Malaria Journal |
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7 |
container_issue |
1 |
container_start_page |
233 |
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1766340510142693376 |