Effects of Brassica oleracea extract on impaired glucose and lipid homeostasis in high-fat diet-induced obese mice
Objective: To examine the effect of Brassica oleracea extract (BO) on impaired glucose and lipid homeostasis in high-fat diet (HFD)-induced obese mice. Methods: Obesity of ICR mice was induced by feeding a HFD (45 kcal% lard fat) for 16 weeks. During the last 8 weeks of study period, obese mice were...
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Wolters Kluwer Medknow Publications
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ftdoajarticles:oai:doaj.org/article:e5dd346cb1ca40e99176e4eb5dfa574d 2023-05-15T15:07:51+02:00 Effects of Brassica oleracea extract on impaired glucose and lipid homeostasis in high-fat diet-induced obese mice Urarat Nanna Jarinyaporn Naowaboot Linda Chularojmontri Pholawat Tingpej Suvara Wattanapitayakul 2019-01-01T00:00:00Z https://doi.org/10.4103/2221-1691.250859 https://doaj.org/article/e5dd346cb1ca40e99176e4eb5dfa574d EN eng Wolters Kluwer Medknow Publications http://www.apjtb.org/article.asp?issn=2221-1691;year=2019;volume=9;issue=2;spage=80;epage=84;aulast=Nanna https://doaj.org/toc/2221-1691 2221-1691 doi:10.4103/2221-1691.250859 https://doaj.org/article/e5dd346cb1ca40e99176e4eb5dfa574d Asian Pacific Journal of Tropical Biomedicine, Vol 9, Iss 2, Pp 80-84 (2019) brassica oleracea obesity lipogenesis insulin resistance Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2019 ftdoajarticles https://doi.org/10.4103/2221-1691.250859 2022-12-31T04:32:42Z Objective: To examine the effect of Brassica oleracea extract (BO) on impaired glucose and lipid homeostasis in high-fat diet (HFD)-induced obese mice. Methods: Obesity of ICR mice was induced by feeding a HFD (45 kcal% lard fat) for 16 weeks. During the last 8 weeks of study period, obese mice were additionally administered with BO (100 and 200 mg/kg/day). The metabolic parameters were determined. The gene expressions of hepatic lipogenesis were also studied. Results: After 8 weeks of treatment, BO (100 and 200 mg/kg) significantly reduced hyperglycemia and improved insulin sensitivity (P < 0.05). The serum lipid (total cholesterol, triglyceride, and non-esterified fatty acid) and hepatic triglyceride and non-esterified fatty acid were decreased (P < 0.05). The levels of insulin and leptin in serum were also decreased (P < 0.05). Moreover, the expressions of hepatic lipogenic genes including sterol regulatory element-binding protein 1c, fatty acid synthase, and acetyl-CoA carboxylase were decreased by BO treatment (P < 0.05). Conclusions: These results suggest that BO is a new therapeutic agent for improving the homeostasis of glucose and lipid in HFD-induced obese mice probably by suppression of lipogenic genes in liver tissue. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 9 2 80 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
brassica oleracea obesity lipogenesis insulin resistance Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
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brassica oleracea obesity lipogenesis insulin resistance Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Urarat Nanna Jarinyaporn Naowaboot Linda Chularojmontri Pholawat Tingpej Suvara Wattanapitayakul Effects of Brassica oleracea extract on impaired glucose and lipid homeostasis in high-fat diet-induced obese mice |
topic_facet |
brassica oleracea obesity lipogenesis insulin resistance Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To examine the effect of Brassica oleracea extract (BO) on impaired glucose and lipid homeostasis in high-fat diet (HFD)-induced obese mice. Methods: Obesity of ICR mice was induced by feeding a HFD (45 kcal% lard fat) for 16 weeks. During the last 8 weeks of study period, obese mice were additionally administered with BO (100 and 200 mg/kg/day). The metabolic parameters were determined. The gene expressions of hepatic lipogenesis were also studied. Results: After 8 weeks of treatment, BO (100 and 200 mg/kg) significantly reduced hyperglycemia and improved insulin sensitivity (P < 0.05). The serum lipid (total cholesterol, triglyceride, and non-esterified fatty acid) and hepatic triglyceride and non-esterified fatty acid were decreased (P < 0.05). The levels of insulin and leptin in serum were also decreased (P < 0.05). Moreover, the expressions of hepatic lipogenic genes including sterol regulatory element-binding protein 1c, fatty acid synthase, and acetyl-CoA carboxylase were decreased by BO treatment (P < 0.05). Conclusions: These results suggest that BO is a new therapeutic agent for improving the homeostasis of glucose and lipid in HFD-induced obese mice probably by suppression of lipogenic genes in liver tissue. |
format |
Article in Journal/Newspaper |
author |
Urarat Nanna Jarinyaporn Naowaboot Linda Chularojmontri Pholawat Tingpej Suvara Wattanapitayakul |
author_facet |
Urarat Nanna Jarinyaporn Naowaboot Linda Chularojmontri Pholawat Tingpej Suvara Wattanapitayakul |
author_sort |
Urarat Nanna |
title |
Effects of Brassica oleracea extract on impaired glucose and lipid homeostasis in high-fat diet-induced obese mice |
title_short |
Effects of Brassica oleracea extract on impaired glucose and lipid homeostasis in high-fat diet-induced obese mice |
title_full |
Effects of Brassica oleracea extract on impaired glucose and lipid homeostasis in high-fat diet-induced obese mice |
title_fullStr |
Effects of Brassica oleracea extract on impaired glucose and lipid homeostasis in high-fat diet-induced obese mice |
title_full_unstemmed |
Effects of Brassica oleracea extract on impaired glucose and lipid homeostasis in high-fat diet-induced obese mice |
title_sort |
effects of brassica oleracea extract on impaired glucose and lipid homeostasis in high-fat diet-induced obese mice |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2019 |
url |
https://doi.org/10.4103/2221-1691.250859 https://doaj.org/article/e5dd346cb1ca40e99176e4eb5dfa574d |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 9, Iss 2, Pp 80-84 (2019) |
op_relation |
http://www.apjtb.org/article.asp?issn=2221-1691;year=2019;volume=9;issue=2;spage=80;epage=84;aulast=Nanna https://doaj.org/toc/2221-1691 2221-1691 doi:10.4103/2221-1691.250859 https://doaj.org/article/e5dd346cb1ca40e99176e4eb5dfa574d |
op_doi |
https://doi.org/10.4103/2221-1691.250859 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
9 |
container_issue |
2 |
container_start_page |
80 |
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1766339268972642304 |