Seroprotection after hepatitis B vaccination amongst infants aged between 12 and 24 months in Ho Chi Minh City, Vietnam
Objective: To assess levels of HBsAb amongst infants who received hepatitis B vaccine in the Expanded Program on Immunization in Vietnam. Methods: A cross-sectional study was carried out at 16 community health centers from February 2016 to July 2017. Eligible infants were tested for HBsAb and HBsAg....
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Wolters Kluwer Medknow Publications
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ftdoajarticles:oai:doaj.org/article:e5d989a9552e40ae8a61568faac766ef 2023-05-15T15:11:43+02:00 Seroprotection after hepatitis B vaccination amongst infants aged between 12 and 24 months in Ho Chi Minh City, Vietnam Giao Huynh Quang Vinh Bui Ngoc Lan Nguyen Le An Pham 2020-01-01T00:00:00Z https://doi.org/10.4103/1995-7645.285828 https://doaj.org/article/e5d989a9552e40ae8a61568faac766ef EN eng Wolters Kluwer Medknow Publications http://www.apjtm.org/article.asp?issn=1995-7645;year=2020;volume=13;issue=7;spage=295;epage=300;aulast=Huynh https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.285828 https://doaj.org/article/e5d989a9552e40ae8a61568faac766ef Asian Pacific Journal of Tropical Medicine, Vol 13, Iss 7, Pp 295-300 (2020) hepatitis b virus hepatitis b vaccine vaccination expanded program on immunization Arctic medicine. Tropical medicine RC955-962 article 2020 ftdoajarticles https://doi.org/10.4103/1995-7645.285828 2022-12-31T05:14:31Z Objective: To assess levels of HBsAb amongst infants who received hepatitis B vaccine in the Expanded Program on Immunization in Vietnam. Methods: A cross-sectional study was carried out at 16 community health centers from February 2016 to July 2017. Eligible infants were tested for HBsAb and HBsAg. Structured questionnaires were used to collect relevant information about the demographics of the parents/caregivers and their infants after physical examination. Results: A total of 199 eligible infants were selected with a mean age of (17.3±4.5) months. Protective antibody levels with HBsAb ≥10 mIU/mL were detected in 68.3% of infants. Of these, antibody levels from 10 to 99 mIU/ mL were 48.5% of those tested and antibody levels ≥100 mlU/mL were recorded as 51.5%. No cases were recorded of being infected with hepatitis B virus. The rate of positive HBsAb level in those who were not wasting and 18 months old was less than that among those who were <18 months old (OR 0.49, 95% CI: 0.26-0.92, P<0.05) while the infants with wasting and <18 months were less likely to be positive HBsAb than those who were not wasting and of the same age group (OR 0.15, 95% CI: 0.04-0.55, P<0.05). Conclusions: Seroprotection against hepatitis B virus was low in the infants tested (at 68.3%), which suggests that the hepatitis B vaccine should be administered with one additional dose for infants between 12 and 24 months of age, particularly those with wasting. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Medicine 13 7 295 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
hepatitis b virus hepatitis b vaccine vaccination expanded program on immunization Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
hepatitis b virus hepatitis b vaccine vaccination expanded program on immunization Arctic medicine. Tropical medicine RC955-962 Giao Huynh Quang Vinh Bui Ngoc Lan Nguyen Le An Pham Seroprotection after hepatitis B vaccination amongst infants aged between 12 and 24 months in Ho Chi Minh City, Vietnam |
topic_facet |
hepatitis b virus hepatitis b vaccine vaccination expanded program on immunization Arctic medicine. Tropical medicine RC955-962 |
description |
Objective: To assess levels of HBsAb amongst infants who received hepatitis B vaccine in the Expanded Program on Immunization in Vietnam. Methods: A cross-sectional study was carried out at 16 community health centers from February 2016 to July 2017. Eligible infants were tested for HBsAb and HBsAg. Structured questionnaires were used to collect relevant information about the demographics of the parents/caregivers and their infants after physical examination. Results: A total of 199 eligible infants were selected with a mean age of (17.3±4.5) months. Protective antibody levels with HBsAb ≥10 mIU/mL were detected in 68.3% of infants. Of these, antibody levels from 10 to 99 mIU/ mL were 48.5% of those tested and antibody levels ≥100 mlU/mL were recorded as 51.5%. No cases were recorded of being infected with hepatitis B virus. The rate of positive HBsAb level in those who were not wasting and 18 months old was less than that among those who were <18 months old (OR 0.49, 95% CI: 0.26-0.92, P<0.05) while the infants with wasting and <18 months were less likely to be positive HBsAb than those who were not wasting and of the same age group (OR 0.15, 95% CI: 0.04-0.55, P<0.05). Conclusions: Seroprotection against hepatitis B virus was low in the infants tested (at 68.3%), which suggests that the hepatitis B vaccine should be administered with one additional dose for infants between 12 and 24 months of age, particularly those with wasting. |
format |
Article in Journal/Newspaper |
author |
Giao Huynh Quang Vinh Bui Ngoc Lan Nguyen Le An Pham |
author_facet |
Giao Huynh Quang Vinh Bui Ngoc Lan Nguyen Le An Pham |
author_sort |
Giao Huynh |
title |
Seroprotection after hepatitis B vaccination amongst infants aged between 12 and 24 months in Ho Chi Minh City, Vietnam |
title_short |
Seroprotection after hepatitis B vaccination amongst infants aged between 12 and 24 months in Ho Chi Minh City, Vietnam |
title_full |
Seroprotection after hepatitis B vaccination amongst infants aged between 12 and 24 months in Ho Chi Minh City, Vietnam |
title_fullStr |
Seroprotection after hepatitis B vaccination amongst infants aged between 12 and 24 months in Ho Chi Minh City, Vietnam |
title_full_unstemmed |
Seroprotection after hepatitis B vaccination amongst infants aged between 12 and 24 months in Ho Chi Minh City, Vietnam |
title_sort |
seroprotection after hepatitis b vaccination amongst infants aged between 12 and 24 months in ho chi minh city, vietnam |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2020 |
url |
https://doi.org/10.4103/1995-7645.285828 https://doaj.org/article/e5d989a9552e40ae8a61568faac766ef |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Medicine, Vol 13, Iss 7, Pp 295-300 (2020) |
op_relation |
http://www.apjtm.org/article.asp?issn=1995-7645;year=2020;volume=13;issue=7;spage=295;epage=300;aulast=Huynh https://doaj.org/toc/2352-4146 2352-4146 doi:10.4103/1995-7645.285828 https://doaj.org/article/e5d989a9552e40ae8a61568faac766ef |
op_doi |
https://doi.org/10.4103/1995-7645.285828 |
container_title |
Asian Pacific Journal of Tropical Medicine |
container_volume |
13 |
container_issue |
7 |
container_start_page |
295 |
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