Active replication of hepatitis B virus (HBV) in HIV type 1 and in HIV type 2 infected patients Replicação ativa do vírus da hepatite B (HBV) em doentes infectados pelo vírus da imunodeficiência humana (HIV) de tipo 1 ou de tipo 2

• Published in: Revista do Instituto de Medicina Tropical de São Paulo
• Main Authors: M.F. Barros, J. Piedade, G. Nunes, W. Canas-Ferreira, A.P. Silva, J.L. Champalimaud, J.A. Machado-Caetano
• Format: Article in Journal/Newspaper
• Language: English
• Published: Universidade de São Paulo (USP) 1996
• Subjects: HIV; HBV active replication; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic
• Online Access: https://doi.org/10.1590/S0036-46651996000400003; https://doaj.org/article/e5ca7aea470a4b63a70bc346c643ad3e

To evaluate the effect of concurrent infection by HIV on HBV infection or immunity, we have studied a group of 66 HIV1+ symptomatic Caucasian patients and another of 38 African HIV2+ asymptomatic individuals, concerning their HBV status: serological markers of infection and presence of HBV-DNA in serum, the last taken as sign of hepatitis B virus active replication, were monitored. HIV+ groups were compared with seronegative controls, adequately matched for age, sex and ethnological background. HBV DNA was found in 7.6% of HIV1+ Caucasian patients and 3.2% of seronegative controls; in African HIV2+ individuals 2.6% were also HBV DNA+, a percentage close to that found in HIV2 seronegative controls (2.9%). No correlation was found between HIV infection and HBV active replication. Immunodepression that follows HIV infection over time may be compatible with a degree of T cell function capable of avoiding reinfection with or reactivation of HBV, even in symptomatic stages of acquired immunodeficiency syndrome. Our findings are relevant to the choice of preventive strategies in populations at risk for HIV and HBV infection. A fim de avaliar as conseqüências da infecção por HIV no curso da infecção por HBV, ou na imunidade anteriormente adquirida, estudamos um grupo de 66 doentes Caucasóides HIV1+ sintomáticos e outro de 38 indivíduos seropositivos para HIV2 e provenientes da África, quanto a marcadores serológicos de infecção por HBV e quanto à presença de DNA viral circulante, tomada como sinal de replicação ativa do vírus da hepatite. Os grupos HIV+ foram comparados com controles seronegativos adequados tendo-se verificado que 7.6% dos doentes HIV1+ eram também HBV-DNA+ (versus 3.2% nos seronegativos) bem como 2.6% dos HIV2+ (versus 2.9% nos controles seronegativos), não sendo as diferenças estatisticamente significativas em qualquer um dos casos e não tendo sido encontrada correlação entre infecção por HIV e replicação ativa de HBV. A imunodeficiência que se instala progressivamente após infecção por HIV, poderá ...