HTLV-I associated myelopathy in the northern region of Brazil (Belém-Pará): serological and clinical features of three cases
Three patients (males, black, ages 37, 40 and 57) attended a university clinic with a progressive paraparesis of obscure origin. One patient who referred disease duration of more than 16 years, showed diminished deep reflexes, bilateral Babinski's sign, diminished sensation of vibration, abnorm...
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ftdoajarticles:oai:doaj.org/article:e5a639e558664bf989a8639c9c4456dd 2023-05-15T15:05:23+02:00 HTLV-I associated myelopathy in the northern region of Brazil (Belém-Pará): serological and clinical features of three cases Ricardo Ishak Fernando Cavalcante Antonio Carlos R. Vallinoto Vânia Nakauth Azevedo Marluísa O. Guimarães Ishak 2002-06-01T00:00:00Z https://doaj.org/article/e5a639e558664bf989a8639c9c4456dd EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822002000300008&tlng=en https://doaj.org/toc/1678-9849 1678-9849 https://doaj.org/article/e5a639e558664bf989a8639c9c4456dd Revista da Sociedade Brasileira de Medicina Tropical, Vol 35, Iss 3, Pp 243-246 (2002) HTLV-I Myelopathy TSP/HAM Neurological disease Arctic medicine. Tropical medicine RC955-962 article 2002 ftdoajarticles 2022-12-31T02:47:39Z Three patients (males, black, ages 37, 40 and 57) attended a university clinic with a progressive paraparesis of obscure origin. One patient who referred disease duration of more than 16 years, showed diminished deep reflexes, bilateral Babinski's sign, diminished sensation of vibration, abnormal bladder function and back pain. The other two patients (with one and six years of disease duration) complained of weakness in one leg, increased deep reflexes and back pain. Babinski's sign and bladder disturbance were also present in the patient with six years of disease. Blood samples tested by an enzyme immune assay and a discriminatory Western blot were positive for HTLV-I. The familial analysis of one patient showed a possible pattern of sexual and vertical transmission of the virus. To the best of our knowledge, these are the first cases of a proven association between HTLV-I and TSP/HAM in Belem, Para, and emphasize the need to actively look for cases of neurological disease associated to the virus. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
HTLV-I Myelopathy TSP/HAM Neurological disease Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
HTLV-I Myelopathy TSP/HAM Neurological disease Arctic medicine. Tropical medicine RC955-962 Ricardo Ishak Fernando Cavalcante Antonio Carlos R. Vallinoto Vânia Nakauth Azevedo Marluísa O. Guimarães Ishak HTLV-I associated myelopathy in the northern region of Brazil (Belém-Pará): serological and clinical features of three cases |
topic_facet |
HTLV-I Myelopathy TSP/HAM Neurological disease Arctic medicine. Tropical medicine RC955-962 |
description |
Three patients (males, black, ages 37, 40 and 57) attended a university clinic with a progressive paraparesis of obscure origin. One patient who referred disease duration of more than 16 years, showed diminished deep reflexes, bilateral Babinski's sign, diminished sensation of vibration, abnormal bladder function and back pain. The other two patients (with one and six years of disease duration) complained of weakness in one leg, increased deep reflexes and back pain. Babinski's sign and bladder disturbance were also present in the patient with six years of disease. Blood samples tested by an enzyme immune assay and a discriminatory Western blot were positive for HTLV-I. The familial analysis of one patient showed a possible pattern of sexual and vertical transmission of the virus. To the best of our knowledge, these are the first cases of a proven association between HTLV-I and TSP/HAM in Belem, Para, and emphasize the need to actively look for cases of neurological disease associated to the virus. |
format |
Article in Journal/Newspaper |
author |
Ricardo Ishak Fernando Cavalcante Antonio Carlos R. Vallinoto Vânia Nakauth Azevedo Marluísa O. Guimarães Ishak |
author_facet |
Ricardo Ishak Fernando Cavalcante Antonio Carlos R. Vallinoto Vânia Nakauth Azevedo Marluísa O. Guimarães Ishak |
author_sort |
Ricardo Ishak |
title |
HTLV-I associated myelopathy in the northern region of Brazil (Belém-Pará): serological and clinical features of three cases |
title_short |
HTLV-I associated myelopathy in the northern region of Brazil (Belém-Pará): serological and clinical features of three cases |
title_full |
HTLV-I associated myelopathy in the northern region of Brazil (Belém-Pará): serological and clinical features of three cases |
title_fullStr |
HTLV-I associated myelopathy in the northern region of Brazil (Belém-Pará): serological and clinical features of three cases |
title_full_unstemmed |
HTLV-I associated myelopathy in the northern region of Brazil (Belém-Pará): serological and clinical features of three cases |
title_sort |
htlv-i associated myelopathy in the northern region of brazil (belém-pará): serological and clinical features of three cases |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2002 |
url |
https://doaj.org/article/e5a639e558664bf989a8639c9c4456dd |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 35, Iss 3, Pp 243-246 (2002) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822002000300008&tlng=en https://doaj.org/toc/1678-9849 1678-9849 https://doaj.org/article/e5a639e558664bf989a8639c9c4456dd |
_version_ |
1766337091078193152 |