Environmental Exposure of Wild Carnivores to Zoonotic Pathogens: Leptospira Infection in the First Free Living Wolf ( Canis lupus Linnaeus, 1758) found Dead in the Friuli Venezia Giulia Region
Leptospirosis is a worldwide-spread zoonosis causing disease and death in dogs and in humans. A Leptospiral infection has been recorded in several wild carnivore species in Europe, but tissue pathological changes were not commonly described. The Grey wolf ( Canis lupus ) has been expanding its distr...
Published in: | International Journal of Environmental Research and Public Health |
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MDPI AG
2021
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Online Access: | https://doi.org/10.3390/ijerph18052512 https://doaj.org/article/e523a7c10c2041a6bc902eac971a4de5 |
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ftdoajarticles:oai:doaj.org/article:e523a7c10c2041a6bc902eac971a4de5 2023-05-15T15:49:35+02:00 Environmental Exposure of Wild Carnivores to Zoonotic Pathogens: Leptospira Infection in the First Free Living Wolf ( Canis lupus Linnaeus, 1758) found Dead in the Friuli Venezia Giulia Region Marco Bregoli Stefano Pesaro Martina Ustulin Denis Vio Paola Beraldo Marco Galeotti Monia Cocchi Laura Lucchese Cristina Bertasio Maria Beatrice Boniotti Luca Lapini Alda Natale 2021-03-01T00:00:00Z https://doi.org/10.3390/ijerph18052512 https://doaj.org/article/e523a7c10c2041a6bc902eac971a4de5 EN eng MDPI AG https://www.mdpi.com/1660-4601/18/5/2512 https://doaj.org/toc/1661-7827 https://doaj.org/toc/1660-4601 doi:10.3390/ijerph18052512 1660-4601 1661-7827 https://doaj.org/article/e523a7c10c2041a6bc902eac971a4de5 International Journal of Environmental Research and Public Health, Vol 18, Iss 2512, p 2512 (2021) Leptospira Canis lupus zoonosis Medicine R article 2021 ftdoajarticles https://doi.org/10.3390/ijerph18052512 2022-12-31T06:31:13Z Leptospirosis is a worldwide-spread zoonosis causing disease and death in dogs and in humans. A Leptospiral infection has been recorded in several wild carnivore species in Europe, but tissue pathological changes were not commonly described. The Grey wolf ( Canis lupus ) has been expanding its distribution range in north-eastern Italy during the last decade. A young wolf, representing the first individual handled in the region, was found road-killed and then submitted to necropsy. Pathological changes included erosive lesions of gingival mucosa, mild liver enlargement, and multifocal degenerative-necrotic areas along with hyperemic reactive lesions; multifocal interstitial nephritis and multifocal lung hemorrhages were observed. A Polymerase Chain Reaction (PCR) able to detect pathogenic species of Leptospira performed on a kidney sample was positive. Serological reactions for serogroup Gryppotyphosa (1:6400), Pomona (1:800), and Icterohaemorrhagiae (1:200) were evidenced by MAT. Genotyping by Multilocus Sequence Typing (MLST) performed on detected Leptospira characterized it as belonging to Sequence Type (ST) 117, which refers to L. kirschneri , serogroup Pomona, serovar Mozdok. Regardless of the role of Leptospira infection as an eventual predisposing factor to the road killing of this wolf, to the best of the authors’ knowledge, this is the first report of Leptospira -induced pathology in a wolf in Europe. Surveys on Leptospira infection in free-ranging wildlife species should be pursued in order to achieve further epidemiological knowledge on the circulation of the Leptospira strain. Article in Journal/Newspaper Canis lupus Directory of Open Access Journals: DOAJ Articles Pomona ENVELOPE(-45.900,-45.900,-60.583,-60.583) International Journal of Environmental Research and Public Health 18 5 2512 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Leptospira Canis lupus zoonosis Medicine R |
spellingShingle |
Leptospira Canis lupus zoonosis Medicine R Marco Bregoli Stefano Pesaro Martina Ustulin Denis Vio Paola Beraldo Marco Galeotti Monia Cocchi Laura Lucchese Cristina Bertasio Maria Beatrice Boniotti Luca Lapini Alda Natale Environmental Exposure of Wild Carnivores to Zoonotic Pathogens: Leptospira Infection in the First Free Living Wolf ( Canis lupus Linnaeus, 1758) found Dead in the Friuli Venezia Giulia Region |
topic_facet |
Leptospira Canis lupus zoonosis Medicine R |
description |
Leptospirosis is a worldwide-spread zoonosis causing disease and death in dogs and in humans. A Leptospiral infection has been recorded in several wild carnivore species in Europe, but tissue pathological changes were not commonly described. The Grey wolf ( Canis lupus ) has been expanding its distribution range in north-eastern Italy during the last decade. A young wolf, representing the first individual handled in the region, was found road-killed and then submitted to necropsy. Pathological changes included erosive lesions of gingival mucosa, mild liver enlargement, and multifocal degenerative-necrotic areas along with hyperemic reactive lesions; multifocal interstitial nephritis and multifocal lung hemorrhages were observed. A Polymerase Chain Reaction (PCR) able to detect pathogenic species of Leptospira performed on a kidney sample was positive. Serological reactions for serogroup Gryppotyphosa (1:6400), Pomona (1:800), and Icterohaemorrhagiae (1:200) were evidenced by MAT. Genotyping by Multilocus Sequence Typing (MLST) performed on detected Leptospira characterized it as belonging to Sequence Type (ST) 117, which refers to L. kirschneri , serogroup Pomona, serovar Mozdok. Regardless of the role of Leptospira infection as an eventual predisposing factor to the road killing of this wolf, to the best of the authors’ knowledge, this is the first report of Leptospira -induced pathology in a wolf in Europe. Surveys on Leptospira infection in free-ranging wildlife species should be pursued in order to achieve further epidemiological knowledge on the circulation of the Leptospira strain. |
format |
Article in Journal/Newspaper |
author |
Marco Bregoli Stefano Pesaro Martina Ustulin Denis Vio Paola Beraldo Marco Galeotti Monia Cocchi Laura Lucchese Cristina Bertasio Maria Beatrice Boniotti Luca Lapini Alda Natale |
author_facet |
Marco Bregoli Stefano Pesaro Martina Ustulin Denis Vio Paola Beraldo Marco Galeotti Monia Cocchi Laura Lucchese Cristina Bertasio Maria Beatrice Boniotti Luca Lapini Alda Natale |
author_sort |
Marco Bregoli |
title |
Environmental Exposure of Wild Carnivores to Zoonotic Pathogens: Leptospira Infection in the First Free Living Wolf ( Canis lupus Linnaeus, 1758) found Dead in the Friuli Venezia Giulia Region |
title_short |
Environmental Exposure of Wild Carnivores to Zoonotic Pathogens: Leptospira Infection in the First Free Living Wolf ( Canis lupus Linnaeus, 1758) found Dead in the Friuli Venezia Giulia Region |
title_full |
Environmental Exposure of Wild Carnivores to Zoonotic Pathogens: Leptospira Infection in the First Free Living Wolf ( Canis lupus Linnaeus, 1758) found Dead in the Friuli Venezia Giulia Region |
title_fullStr |
Environmental Exposure of Wild Carnivores to Zoonotic Pathogens: Leptospira Infection in the First Free Living Wolf ( Canis lupus Linnaeus, 1758) found Dead in the Friuli Venezia Giulia Region |
title_full_unstemmed |
Environmental Exposure of Wild Carnivores to Zoonotic Pathogens: Leptospira Infection in the First Free Living Wolf ( Canis lupus Linnaeus, 1758) found Dead in the Friuli Venezia Giulia Region |
title_sort |
environmental exposure of wild carnivores to zoonotic pathogens: leptospira infection in the first free living wolf ( canis lupus linnaeus, 1758) found dead in the friuli venezia giulia region |
publisher |
MDPI AG |
publishDate |
2021 |
url |
https://doi.org/10.3390/ijerph18052512 https://doaj.org/article/e523a7c10c2041a6bc902eac971a4de5 |
long_lat |
ENVELOPE(-45.900,-45.900,-60.583,-60.583) |
geographic |
Pomona |
geographic_facet |
Pomona |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_source |
International Journal of Environmental Research and Public Health, Vol 18, Iss 2512, p 2512 (2021) |
op_relation |
https://www.mdpi.com/1660-4601/18/5/2512 https://doaj.org/toc/1661-7827 https://doaj.org/toc/1660-4601 doi:10.3390/ijerph18052512 1660-4601 1661-7827 https://doaj.org/article/e523a7c10c2041a6bc902eac971a4de5 |
op_doi |
https://doi.org/10.3390/ijerph18052512 |
container_title |
International Journal of Environmental Research and Public Health |
container_volume |
18 |
container_issue |
5 |
container_start_page |
2512 |
_version_ |
1766384607768346624 |