Vector competence of biting midges and mosquitoes for Shuni virus.
Background Shuni virus (SHUV) is an orthobunyavirus that belongs to the Simbu serogroup. SHUV was isolated from diverse species of domesticated animals and wildlife, and is associated with neurological disease, abortions, and congenital malformations. Recently, SHUV caused outbreaks among ruminants...
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ftdoajarticles:oai:doaj.org/article:e50c8901940c4a078525488aa836d0eb 2023-05-15T15:11:00+02:00 Vector competence of biting midges and mosquitoes for Shuni virus. Tim W R Möhlmann Judith Oymans Paul J Wichgers Schreur Constantianus J M Koenraadt Jeroen Kortekaas Chantal B F Vogels 2018-12-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0006993 https://doaj.org/article/e50c8901940c4a078525488aa836d0eb EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0006993 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006993 https://doaj.org/article/e50c8901940c4a078525488aa836d0eb PLoS Neglected Tropical Diseases, Vol 12, Iss 12, p e0006993 (2018) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2018 ftdoajarticles https://doi.org/10.1371/journal.pntd.0006993 2022-12-31T07:51:21Z Background Shuni virus (SHUV) is an orthobunyavirus that belongs to the Simbu serogroup. SHUV was isolated from diverse species of domesticated animals and wildlife, and is associated with neurological disease, abortions, and congenital malformations. Recently, SHUV caused outbreaks among ruminants in Israel, representing the first incursions outside the African continent. The isolation of SHUV from a febrile child in Nigeria and seroprevalence among veterinarians in South Africa suggests that the virus may have zoonotic potential as well. The high pathogenicity, extremely broad tropism, potential transmission via both biting midges and mosquitoes, and zoonotic features warrants prioritization of SHUV for further research. Additional knowledge is essential to accurately determine the risk for animal and human health, and to assess the risk of future epizootics and epidemics. To gain first insights into the potential involvement of arthropod vectors in SHUV transmission, we have investigated the ability of SHUV to infect and disseminate in laboratory-reared biting midges and mosquitoes. Methodology/principal findings Culicoides nubeculosus, C. sonorensis, Culex pipiens pipiens, and Aedes aegypti were orally exposed to SHUV by providing an infectious blood meal. Biting midges showed high infection rates of approximately 40-60%, whereas infection rates of mosquitoes were lower than 2%. SHUV successfully disseminated in both species of biting midges, but no evidence of transmission in orally exposed mosquitoes was found. Conclusions/significance The results of this study show that different species of Culicoides biting midges are susceptible to infection and dissemination of SHUV, whereas the two mosquito species tested were found not to be susceptible. Article in Journal/Newspaper Arctic Human health Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 12 12 e0006993 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Tim W R Möhlmann Judith Oymans Paul J Wichgers Schreur Constantianus J M Koenraadt Jeroen Kortekaas Chantal B F Vogels Vector competence of biting midges and mosquitoes for Shuni virus. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Shuni virus (SHUV) is an orthobunyavirus that belongs to the Simbu serogroup. SHUV was isolated from diverse species of domesticated animals and wildlife, and is associated with neurological disease, abortions, and congenital malformations. Recently, SHUV caused outbreaks among ruminants in Israel, representing the first incursions outside the African continent. The isolation of SHUV from a febrile child in Nigeria and seroprevalence among veterinarians in South Africa suggests that the virus may have zoonotic potential as well. The high pathogenicity, extremely broad tropism, potential transmission via both biting midges and mosquitoes, and zoonotic features warrants prioritization of SHUV for further research. Additional knowledge is essential to accurately determine the risk for animal and human health, and to assess the risk of future epizootics and epidemics. To gain first insights into the potential involvement of arthropod vectors in SHUV transmission, we have investigated the ability of SHUV to infect and disseminate in laboratory-reared biting midges and mosquitoes. Methodology/principal findings Culicoides nubeculosus, C. sonorensis, Culex pipiens pipiens, and Aedes aegypti were orally exposed to SHUV by providing an infectious blood meal. Biting midges showed high infection rates of approximately 40-60%, whereas infection rates of mosquitoes were lower than 2%. SHUV successfully disseminated in both species of biting midges, but no evidence of transmission in orally exposed mosquitoes was found. Conclusions/significance The results of this study show that different species of Culicoides biting midges are susceptible to infection and dissemination of SHUV, whereas the two mosquito species tested were found not to be susceptible. |
format |
Article in Journal/Newspaper |
author |
Tim W R Möhlmann Judith Oymans Paul J Wichgers Schreur Constantianus J M Koenraadt Jeroen Kortekaas Chantal B F Vogels |
author_facet |
Tim W R Möhlmann Judith Oymans Paul J Wichgers Schreur Constantianus J M Koenraadt Jeroen Kortekaas Chantal B F Vogels |
author_sort |
Tim W R Möhlmann |
title |
Vector competence of biting midges and mosquitoes for Shuni virus. |
title_short |
Vector competence of biting midges and mosquitoes for Shuni virus. |
title_full |
Vector competence of biting midges and mosquitoes for Shuni virus. |
title_fullStr |
Vector competence of biting midges and mosquitoes for Shuni virus. |
title_full_unstemmed |
Vector competence of biting midges and mosquitoes for Shuni virus. |
title_sort |
vector competence of biting midges and mosquitoes for shuni virus. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2018 |
url |
https://doi.org/10.1371/journal.pntd.0006993 https://doaj.org/article/e50c8901940c4a078525488aa836d0eb |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Human health |
genre_facet |
Arctic Human health |
op_source |
PLoS Neglected Tropical Diseases, Vol 12, Iss 12, p e0006993 (2018) |
op_relation |
https://doi.org/10.1371/journal.pntd.0006993 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006993 https://doaj.org/article/e50c8901940c4a078525488aa836d0eb |
op_doi |
https://doi.org/10.1371/journal.pntd.0006993 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
12 |
container_issue |
12 |
container_start_page |
e0006993 |
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1766341914788888576 |