Lipid profile and body composition of HIV-1 infected patients treated with highly active antiretroviral therapy
Highly active antiretroviral therapy (HAART) has been associated with the development of a clinical group and metabolic disorders such as peripheral lipodystrophy syndrome in AIDS. The aim of this study was to analyze the lipid profile, the clinical aspects, and the body composition of HIV-1 infecte...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
---|---|
Main Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
SciELO
2005
|
Subjects: | |
Online Access: | https://doi.org/10.1590/S1678-91992005000200006 https://doaj.org/article/e4d6c84e829f47fca9b7319e32607c9a |
id |
ftdoajarticles:oai:doaj.org/article:e4d6c84e829f47fca9b7319e32607c9a |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:e4d6c84e829f47fca9b7319e32607c9a 2023-05-15T15:11:12+02:00 Lipid profile and body composition of HIV-1 infected patients treated with highly active antiretroviral therapy L. C. R. Pontes L. R. Carvalho L. R. Souza E. B. S. M. Trindade P. C. M. Pereira 2005-06-01T00:00:00Z https://doi.org/10.1590/S1678-91992005000200006 https://doaj.org/article/e4d6c84e829f47fca9b7319e32607c9a EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992005000200006 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992005000200006 1678-9199 https://doaj.org/article/e4d6c84e829f47fca9b7319e32607c9a Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 11, Iss 2, Pp 143-159 (2005) lipodystrophy HIV-1 highly active antiretroviral therapy dyslipidemia hypertriglyceridemia Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2005 ftdoajarticles https://doi.org/10.1590/S1678-91992005000200006 2022-12-31T03:44:09Z Highly active antiretroviral therapy (HAART) has been associated with the development of a clinical group and metabolic disorders such as peripheral lipodystrophy syndrome in AIDS. The aim of this study was to analyze the lipid profile, the clinical aspects, and the body composition of HIV-1 infected individuals treated with or without protease inhibitor (PI) during the highly active antiretroviral therapy. In total, 62 individuals were evaluated in this study; 15 healthy individuals (Control Group: CG), 11 HIV-1 infected individuals treated without antiretroviral therapy (Group 1: G1), 14 HIV-1 infected individuals treated with antiretroviral therapy plus protease inhibitor (Group 2: G2), and 22 HIV-1 infected individuals treated with antiretroviral therapy without protease inhibitor (Group 3: G3), mean age 35 years old. The time interval for G2 and G3 was greater than or equal to nine months. Patients receiving HAART with PI had significantly lower viral loads, hypertriglyceridemia, and low HDL levels (p<0.05). There were no differences between groups in relation to the lean body mass percentage obtained by mid-arm muscle circumference adequacy or by bioelectrical impedance. The lower percentage of body fat observed in all the HIV-1 infected patients by antropometric assessment and the decreased tricipital skinfold adequacy in the group treated with PI in relation to CG may suggest lipodystrophy in the upper limbs, especially on those treated with PI. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 11 2 143 159 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
lipodystrophy HIV-1 highly active antiretroviral therapy dyslipidemia hypertriglyceridemia Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
lipodystrophy HIV-1 highly active antiretroviral therapy dyslipidemia hypertriglyceridemia Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 L. C. R. Pontes L. R. Carvalho L. R. Souza E. B. S. M. Trindade P. C. M. Pereira Lipid profile and body composition of HIV-1 infected patients treated with highly active antiretroviral therapy |
topic_facet |
lipodystrophy HIV-1 highly active antiretroviral therapy dyslipidemia hypertriglyceridemia Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Highly active antiretroviral therapy (HAART) has been associated with the development of a clinical group and metabolic disorders such as peripheral lipodystrophy syndrome in AIDS. The aim of this study was to analyze the lipid profile, the clinical aspects, and the body composition of HIV-1 infected individuals treated with or without protease inhibitor (PI) during the highly active antiretroviral therapy. In total, 62 individuals were evaluated in this study; 15 healthy individuals (Control Group: CG), 11 HIV-1 infected individuals treated without antiretroviral therapy (Group 1: G1), 14 HIV-1 infected individuals treated with antiretroviral therapy plus protease inhibitor (Group 2: G2), and 22 HIV-1 infected individuals treated with antiretroviral therapy without protease inhibitor (Group 3: G3), mean age 35 years old. The time interval for G2 and G3 was greater than or equal to nine months. Patients receiving HAART with PI had significantly lower viral loads, hypertriglyceridemia, and low HDL levels (p<0.05). There were no differences between groups in relation to the lean body mass percentage obtained by mid-arm muscle circumference adequacy or by bioelectrical impedance. The lower percentage of body fat observed in all the HIV-1 infected patients by antropometric assessment and the decreased tricipital skinfold adequacy in the group treated with PI in relation to CG may suggest lipodystrophy in the upper limbs, especially on those treated with PI. |
format |
Article in Journal/Newspaper |
author |
L. C. R. Pontes L. R. Carvalho L. R. Souza E. B. S. M. Trindade P. C. M. Pereira |
author_facet |
L. C. R. Pontes L. R. Carvalho L. R. Souza E. B. S. M. Trindade P. C. M. Pereira |
author_sort |
L. C. R. Pontes |
title |
Lipid profile and body composition of HIV-1 infected patients treated with highly active antiretroviral therapy |
title_short |
Lipid profile and body composition of HIV-1 infected patients treated with highly active antiretroviral therapy |
title_full |
Lipid profile and body composition of HIV-1 infected patients treated with highly active antiretroviral therapy |
title_fullStr |
Lipid profile and body composition of HIV-1 infected patients treated with highly active antiretroviral therapy |
title_full_unstemmed |
Lipid profile and body composition of HIV-1 infected patients treated with highly active antiretroviral therapy |
title_sort |
lipid profile and body composition of hiv-1 infected patients treated with highly active antiretroviral therapy |
publisher |
SciELO |
publishDate |
2005 |
url |
https://doi.org/10.1590/S1678-91992005000200006 https://doaj.org/article/e4d6c84e829f47fca9b7319e32607c9a |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 11, Iss 2, Pp 143-159 (2005) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992005000200006 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992005000200006 1678-9199 https://doaj.org/article/e4d6c84e829f47fca9b7319e32607c9a |
op_doi |
https://doi.org/10.1590/S1678-91992005000200006 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
11 |
container_issue |
2 |
container_start_page |
143 |
op_container_end_page |
159 |
_version_ |
1766342101475262464 |