Automated red blood cell exchange as an adjunctive treatment for severe Plasmodium falciparum malaria at the Vienna General Hospital in Austria: a retrospective cohort study
Abstract Background Severe falciparum malaria is associated with considerable rates of mortality, despite the administration of appropriate anti-malarial treatment. Since overall survival is associated with total parasite biomass, blood exchange transfusion has been proposed as a potential method to...
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ftdoajarticles:oai:doaj.org/article:e4cb7de181d4406e9c997d5bba0e57b7 2023-05-15T15:18:34+02:00 Automated red blood cell exchange as an adjunctive treatment for severe Plasmodium falciparum malaria at the Vienna General Hospital in Austria: a retrospective cohort study Auer-Hackenberg Lorenz Staudinger Thomas Bojic Andja Locker Gottfried Leitner Gerda C Graninger Wolfgang Winkler Stefan Ramharter Michael Worel Nina 2012-05-01T00:00:00Z https://doi.org/10.1186/1475-2875-11-158 https://doaj.org/article/e4cb7de181d4406e9c997d5bba0e57b7 EN eng BMC http://www.malariajournal.com/content/11/1/158 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-158 1475-2875 https://doaj.org/article/e4cb7de181d4406e9c997d5bba0e57b7 Malaria Journal, Vol 11, Iss 1, p 158 (2012) Malaria Severe malaria Plasmodium falciparum Erythrocyte transfusion Cytapheresis Erythrocytapheresis Automated red blood cell exchange Whole blood exchange transfusion Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2012 ftdoajarticles https://doi.org/10.1186/1475-2875-11-158 2022-12-31T00:52:04Z Abstract Background Severe falciparum malaria is associated with considerable rates of mortality, despite the administration of appropriate anti-malarial treatment. Since overall survival is associated with total parasite biomass, blood exchange transfusion has been proposed as a potential method to rapidly reduce peripheral parasitaemia. However, current evidence suggests that this treatment modality may not improve outcome. Automated red blood cell exchange (also referred to as “erythrocytapheresis”) has been advocated as an alternative method to rapidly remove parasites from circulating blood without affecting patients’ volume and electrolyte status. However, only limited evidence from case reports and case series is available for this adjunctive treatment. This retrospective cohort study describes the use of automated red blood cell exchange for the treatment of severe malaria at the Medical University of Vienna. Methods Epidemiologic data for imported malaria cases in Austria are reported and data of patients treated for malaria at the General Hospital/Medical University of Vienna were extracted from electronic hospital records. Results Between 2000 and 2010, 146 patients were hospitalized at the Medical University of Vienna due to malaria and 16 of those were classified as severe malaria cases. Eleven patients of this cohort were potentially eligible for an adjunctive treatment with automated red blood cell exchange. Five patients eventually underwent this procedure within a period of seven hours (range: 3–19 hours) after hospital admission. Six patients did not undergo this adjunctive treatment following the decision of the treating physician. The procedure was well tolerated in all cases and rapid reduction in parasite counts was achieved without occurrence of haemodynamic complications. One patient died within seven days, whereas four patients survived without any sequelae. Discussion and conclusion Automated red blood cell exchange was a safe and efficient procedure to rapidly clear peripheral ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 11 1 158 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Malaria Severe malaria Plasmodium falciparum Erythrocyte transfusion Cytapheresis Erythrocytapheresis Automated red blood cell exchange Whole blood exchange transfusion Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Malaria Severe malaria Plasmodium falciparum Erythrocyte transfusion Cytapheresis Erythrocytapheresis Automated red blood cell exchange Whole blood exchange transfusion Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Auer-Hackenberg Lorenz Staudinger Thomas Bojic Andja Locker Gottfried Leitner Gerda C Graninger Wolfgang Winkler Stefan Ramharter Michael Worel Nina Automated red blood cell exchange as an adjunctive treatment for severe Plasmodium falciparum malaria at the Vienna General Hospital in Austria: a retrospective cohort study |
topic_facet |
Malaria Severe malaria Plasmodium falciparum Erythrocyte transfusion Cytapheresis Erythrocytapheresis Automated red blood cell exchange Whole blood exchange transfusion Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Severe falciparum malaria is associated with considerable rates of mortality, despite the administration of appropriate anti-malarial treatment. Since overall survival is associated with total parasite biomass, blood exchange transfusion has been proposed as a potential method to rapidly reduce peripheral parasitaemia. However, current evidence suggests that this treatment modality may not improve outcome. Automated red blood cell exchange (also referred to as “erythrocytapheresis”) has been advocated as an alternative method to rapidly remove parasites from circulating blood without affecting patients’ volume and electrolyte status. However, only limited evidence from case reports and case series is available for this adjunctive treatment. This retrospective cohort study describes the use of automated red blood cell exchange for the treatment of severe malaria at the Medical University of Vienna. Methods Epidemiologic data for imported malaria cases in Austria are reported and data of patients treated for malaria at the General Hospital/Medical University of Vienna were extracted from electronic hospital records. Results Between 2000 and 2010, 146 patients were hospitalized at the Medical University of Vienna due to malaria and 16 of those were classified as severe malaria cases. Eleven patients of this cohort were potentially eligible for an adjunctive treatment with automated red blood cell exchange. Five patients eventually underwent this procedure within a period of seven hours (range: 3–19 hours) after hospital admission. Six patients did not undergo this adjunctive treatment following the decision of the treating physician. The procedure was well tolerated in all cases and rapid reduction in parasite counts was achieved without occurrence of haemodynamic complications. One patient died within seven days, whereas four patients survived without any sequelae. Discussion and conclusion Automated red blood cell exchange was a safe and efficient procedure to rapidly clear peripheral ... |
format |
Article in Journal/Newspaper |
author |
Auer-Hackenberg Lorenz Staudinger Thomas Bojic Andja Locker Gottfried Leitner Gerda C Graninger Wolfgang Winkler Stefan Ramharter Michael Worel Nina |
author_facet |
Auer-Hackenberg Lorenz Staudinger Thomas Bojic Andja Locker Gottfried Leitner Gerda C Graninger Wolfgang Winkler Stefan Ramharter Michael Worel Nina |
author_sort |
Auer-Hackenberg Lorenz |
title |
Automated red blood cell exchange as an adjunctive treatment for severe Plasmodium falciparum malaria at the Vienna General Hospital in Austria: a retrospective cohort study |
title_short |
Automated red blood cell exchange as an adjunctive treatment for severe Plasmodium falciparum malaria at the Vienna General Hospital in Austria: a retrospective cohort study |
title_full |
Automated red blood cell exchange as an adjunctive treatment for severe Plasmodium falciparum malaria at the Vienna General Hospital in Austria: a retrospective cohort study |
title_fullStr |
Automated red blood cell exchange as an adjunctive treatment for severe Plasmodium falciparum malaria at the Vienna General Hospital in Austria: a retrospective cohort study |
title_full_unstemmed |
Automated red blood cell exchange as an adjunctive treatment for severe Plasmodium falciparum malaria at the Vienna General Hospital in Austria: a retrospective cohort study |
title_sort |
automated red blood cell exchange as an adjunctive treatment for severe plasmodium falciparum malaria at the vienna general hospital in austria: a retrospective cohort study |
publisher |
BMC |
publishDate |
2012 |
url |
https://doi.org/10.1186/1475-2875-11-158 https://doaj.org/article/e4cb7de181d4406e9c997d5bba0e57b7 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 11, Iss 1, p 158 (2012) |
op_relation |
http://www.malariajournal.com/content/11/1/158 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-11-158 1475-2875 https://doaj.org/article/e4cb7de181d4406e9c997d5bba0e57b7 |
op_doi |
https://doi.org/10.1186/1475-2875-11-158 |
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Malaria Journal |
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11 |
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158 |
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