Inversion 2La is associated with enhanced desiccation resistance in Anopheles gambiae
Abstract Background Anopheles gambiae , the principal vector of malignant malaria in Africa, occupies a wide range of habitats. Environmental flexibility may be conferred by a number of chromosomal inversions non-randomly associated with aridity, including 2La. The purpose of this study was to deter...
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ftdoajarticles:oai:doaj.org/article:e4bff77e25bd4ff78ea8188215289faf 2023-05-15T15:13:42+02:00 Inversion 2La is associated with enhanced desiccation resistance in Anopheles gambiae Costantini Carlo Rocca Kyle AC Gray Emilie M Besansky Nora J 2009-09-01T00:00:00Z https://doi.org/10.1186/1475-2875-8-215 https://doaj.org/article/e4bff77e25bd4ff78ea8188215289faf EN eng BMC http://www.malariajournal.com/content/8/1/215 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-8-215 1475-2875 https://doaj.org/article/e4bff77e25bd4ff78ea8188215289faf Malaria Journal, Vol 8, Iss 1, p 215 (2009) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2009 ftdoajarticles https://doi.org/10.1186/1475-2875-8-215 2022-12-30T22:09:17Z Abstract Background Anopheles gambiae , the principal vector of malignant malaria in Africa, occupies a wide range of habitats. Environmental flexibility may be conferred by a number of chromosomal inversions non-randomly associated with aridity, including 2La. The purpose of this study was to determine the physiological mechanisms associated with the 2La inversion that may result in the preferential survival of its carriers in hygrically-stressful environments. Methods Two homokaryotypic populations of A. gambiae (inverted 2La and standard 2L+ a ) were created from a parental laboratory colony polymorphic for 2La and standard for all other known inversions. Desiccation resistance, water, energy and dry mass of adult females of both populations were compared at several ages and following acclimation to a more arid environment. Results Females carrying 2La were significantly more resistant to desiccation than 2L+ a females at emergence and four days post-emergence, for different reasons. Teneral 2La females had lower rates of water loss than their 2L+ a counterparts, while at four days, 2La females had higher initial water content. No differences in desiccation resistance were found at eight days, with or without acclimation. However, acclimation resulted in both populations significantly reducing their rates of water loss and increasing their desiccation resistance. Acclimation had contrasting effects on the body characteristics of the two populations: 2La females boosted their glycogen stores and decreased lipids, whereas 2La females did the contrary. Conclusion Variation in rates of water loss and response to acclimation are associated with alternative arrangements of the 2La inversion. Understanding the mechanisms underlying these traits will help explain how inversion polymorphisms permit exploitation of a heterogeneous environment by this disease vector. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 8 1 215 |
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Directory of Open Access Journals: DOAJ Articles |
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language |
English |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Costantini Carlo Rocca Kyle AC Gray Emilie M Besansky Nora J Inversion 2La is associated with enhanced desiccation resistance in Anopheles gambiae |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Anopheles gambiae , the principal vector of malignant malaria in Africa, occupies a wide range of habitats. Environmental flexibility may be conferred by a number of chromosomal inversions non-randomly associated with aridity, including 2La. The purpose of this study was to determine the physiological mechanisms associated with the 2La inversion that may result in the preferential survival of its carriers in hygrically-stressful environments. Methods Two homokaryotypic populations of A. gambiae (inverted 2La and standard 2L+ a ) were created from a parental laboratory colony polymorphic for 2La and standard for all other known inversions. Desiccation resistance, water, energy and dry mass of adult females of both populations were compared at several ages and following acclimation to a more arid environment. Results Females carrying 2La were significantly more resistant to desiccation than 2L+ a females at emergence and four days post-emergence, for different reasons. Teneral 2La females had lower rates of water loss than their 2L+ a counterparts, while at four days, 2La females had higher initial water content. No differences in desiccation resistance were found at eight days, with or without acclimation. However, acclimation resulted in both populations significantly reducing their rates of water loss and increasing their desiccation resistance. Acclimation had contrasting effects on the body characteristics of the two populations: 2La females boosted their glycogen stores and decreased lipids, whereas 2La females did the contrary. Conclusion Variation in rates of water loss and response to acclimation are associated with alternative arrangements of the 2La inversion. Understanding the mechanisms underlying these traits will help explain how inversion polymorphisms permit exploitation of a heterogeneous environment by this disease vector. |
format |
Article in Journal/Newspaper |
author |
Costantini Carlo Rocca Kyle AC Gray Emilie M Besansky Nora J |
author_facet |
Costantini Carlo Rocca Kyle AC Gray Emilie M Besansky Nora J |
author_sort |
Costantini Carlo |
title |
Inversion 2La is associated with enhanced desiccation resistance in Anopheles gambiae |
title_short |
Inversion 2La is associated with enhanced desiccation resistance in Anopheles gambiae |
title_full |
Inversion 2La is associated with enhanced desiccation resistance in Anopheles gambiae |
title_fullStr |
Inversion 2La is associated with enhanced desiccation resistance in Anopheles gambiae |
title_full_unstemmed |
Inversion 2La is associated with enhanced desiccation resistance in Anopheles gambiae |
title_sort |
inversion 2la is associated with enhanced desiccation resistance in anopheles gambiae |
publisher |
BMC |
publishDate |
2009 |
url |
https://doi.org/10.1186/1475-2875-8-215 https://doaj.org/article/e4bff77e25bd4ff78ea8188215289faf |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 8, Iss 1, p 215 (2009) |
op_relation |
http://www.malariajournal.com/content/8/1/215 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-8-215 1475-2875 https://doaj.org/article/e4bff77e25bd4ff78ea8188215289faf |
op_doi |
https://doi.org/10.1186/1475-2875-8-215 |
container_title |
Malaria Journal |
container_volume |
8 |
container_issue |
1 |
container_start_page |
215 |
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1766344219288403968 |