Characteristics of primary biliary cirrhosis in British Columbia's First Nations population
Primary biliary cirrhosis (PBC) is a rare, autoimmune liver disorder characterized by progressive destruction of intrahepatic bile ducts, that results in portal inflammation, scarring, cirrhosis and, eventually, liver failure. Although considered rare in Canadian populations, it is the leading indic...
Published in: | Canadian Journal of Gastroenterology |
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ftdoajarticles:oai:doaj.org/article:e4a5d6396a864c9494f8b752d36c1ba0 2023-05-15T16:13:57+02:00 Characteristics of primary biliary cirrhosis in British Columbia's First Nations population Laura Arbour Rosemarie Rupps Leigh Field Paul Ross Anders Erikson Harvey Henderson Warren Hill Eric M Yoshida 2005-01-01T00:00:00Z https://doi.org/10.1155/2005/203028 https://doaj.org/article/e4a5d6396a864c9494f8b752d36c1ba0 EN eng Hindawi Limited http://dx.doi.org/10.1155/2005/203028 https://doaj.org/toc/0835-7900 0835-7900 doi:10.1155/2005/203028 https://doaj.org/article/e4a5d6396a864c9494f8b752d36c1ba0 Canadian Journal of Gastroenterology, Vol 19, Iss 5, Pp 305-310 (2005) Diseases of the digestive system. Gastroenterology RC799-869 article 2005 ftdoajarticles https://doi.org/10.1155/2005/203028 2022-12-31T07:22:23Z Primary biliary cirrhosis (PBC) is a rare, autoimmune liver disorder characterized by progressive destruction of intrahepatic bile ducts, that results in portal inflammation, scarring, cirrhosis and, eventually, liver failure. Although considered rare in Canadian populations, it is the leading indication for referral for liver transplantation in British Columbia's First Nations population. Previously, an expanded review of all cases referred to the British Columbia Transplant Society for PBC was carried out comparing the demographics of those of First Nations descent with those not of First Nations descent. The review suggested that the rate of referral for transplantation was eight times higher for those of First Nations descent compared with those of other descent (P=0.0001), and a disproportionate number of the First Nations cases lived on Vancouver Island (48% of cases versus 18% expected, P<0.05). Additionally, the age of referral was significantly younger (45.9 versus 54.3 years) for those of First Nations descent and there are fewer First Nations men referred (1:34) than expected. For the purpose of the present report, 28 symptomatic cases were ascertained separately and reviewed in a clinical study to delineate the features of this population. Article in Journal/Newspaper First Nations Directory of Open Access Journals: DOAJ Articles Canadian Journal of Gastroenterology 19 5 305 310 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Diseases of the digestive system. Gastroenterology RC799-869 |
spellingShingle |
Diseases of the digestive system. Gastroenterology RC799-869 Laura Arbour Rosemarie Rupps Leigh Field Paul Ross Anders Erikson Harvey Henderson Warren Hill Eric M Yoshida Characteristics of primary biliary cirrhosis in British Columbia's First Nations population |
topic_facet |
Diseases of the digestive system. Gastroenterology RC799-869 |
description |
Primary biliary cirrhosis (PBC) is a rare, autoimmune liver disorder characterized by progressive destruction of intrahepatic bile ducts, that results in portal inflammation, scarring, cirrhosis and, eventually, liver failure. Although considered rare in Canadian populations, it is the leading indication for referral for liver transplantation in British Columbia's First Nations population. Previously, an expanded review of all cases referred to the British Columbia Transplant Society for PBC was carried out comparing the demographics of those of First Nations descent with those not of First Nations descent. The review suggested that the rate of referral for transplantation was eight times higher for those of First Nations descent compared with those of other descent (P=0.0001), and a disproportionate number of the First Nations cases lived on Vancouver Island (48% of cases versus 18% expected, P<0.05). Additionally, the age of referral was significantly younger (45.9 versus 54.3 years) for those of First Nations descent and there are fewer First Nations men referred (1:34) than expected. For the purpose of the present report, 28 symptomatic cases were ascertained separately and reviewed in a clinical study to delineate the features of this population. |
format |
Article in Journal/Newspaper |
author |
Laura Arbour Rosemarie Rupps Leigh Field Paul Ross Anders Erikson Harvey Henderson Warren Hill Eric M Yoshida |
author_facet |
Laura Arbour Rosemarie Rupps Leigh Field Paul Ross Anders Erikson Harvey Henderson Warren Hill Eric M Yoshida |
author_sort |
Laura Arbour |
title |
Characteristics of primary biliary cirrhosis in British Columbia's First Nations population |
title_short |
Characteristics of primary biliary cirrhosis in British Columbia's First Nations population |
title_full |
Characteristics of primary biliary cirrhosis in British Columbia's First Nations population |
title_fullStr |
Characteristics of primary biliary cirrhosis in British Columbia's First Nations population |
title_full_unstemmed |
Characteristics of primary biliary cirrhosis in British Columbia's First Nations population |
title_sort |
characteristics of primary biliary cirrhosis in british columbia's first nations population |
publisher |
Hindawi Limited |
publishDate |
2005 |
url |
https://doi.org/10.1155/2005/203028 https://doaj.org/article/e4a5d6396a864c9494f8b752d36c1ba0 |
genre |
First Nations |
genre_facet |
First Nations |
op_source |
Canadian Journal of Gastroenterology, Vol 19, Iss 5, Pp 305-310 (2005) |
op_relation |
http://dx.doi.org/10.1155/2005/203028 https://doaj.org/toc/0835-7900 0835-7900 doi:10.1155/2005/203028 https://doaj.org/article/e4a5d6396a864c9494f8b752d36c1ba0 |
op_doi |
https://doi.org/10.1155/2005/203028 |
container_title |
Canadian Journal of Gastroenterology |
container_volume |
19 |
container_issue |
5 |
container_start_page |
305 |
op_container_end_page |
310 |
_version_ |
1765999794807898112 |