Effects of interaction CdZn on serum-PSA level and prostate histology in rats
Objective: To assess cadmium sulfate (CdSO4) and zinc chloride (ZnCl2) antagonist effects on the prostate specific antigen and prostatic cell organization in rats. Methods: The study included 40 adult male rats, divided into four groups: Group 1 (CdSO4), Group 2 (ZnCl2), Group 3 (CdSO4ZnCl2) and Gr...
Published in: | Asian Pacific Journal of Tropical Biomedicine |
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Language: | English |
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Wolters Kluwer Medknow Publications
2017
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Online Access: | https://doi.org/10.1016/j.apjtb.2016.12.012 https://doaj.org/article/e49e99ef38824fb5bc6436b8b6c4fe4b |
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ftdoajarticles:oai:doaj.org/article:e49e99ef38824fb5bc6436b8b6c4fe4b 2023-05-15T15:03:14+02:00 Effects of interaction CdZn on serum-PSA level and prostate histology in rats Abdelkrim Berroukche Mohamed Terras Abdelrahmane Labani Hafsa Dellaoui Wassila Lansari 2017-03-01T00:00:00Z https://doi.org/10.1016/j.apjtb.2016.12.012 https://doaj.org/article/e49e99ef38824fb5bc6436b8b6c4fe4b EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169116311418 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2016.12.012 https://doaj.org/article/e49e99ef38824fb5bc6436b8b6c4fe4b Asian Pacific Journal of Tropical Biomedicine, Vol 7, Iss 3, Pp 245-248 (2017) Cadmium Zinc PSA Hyperplasia Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2017 ftdoajarticles https://doi.org/10.1016/j.apjtb.2016.12.012 2022-12-31T15:38:16Z Objective: To assess cadmium sulfate (CdSO4) and zinc chloride (ZnCl2) antagonist effects on the prostate specific antigen and prostatic cell organization in rats. Methods: The study included 40 adult male rats, divided into four groups: Group 1 (CdSO4), Group 2 (ZnCl2), Group 3 (CdSO4ZnCl2) and Group 4 (control). Animals were treated with CdSO4 and ZnCl2 at the same dose (15 mg/L) during 30 days. Results: It was showed a higher body weight and a lowering serum-prostate specific antigen concentration [(1.8 ± 0.6) ng/mL] in animals treated with CdSO4. CdSO4 induced a cyto-nuclear atypia, proliferative lesions, hyperplasia and precancerous foci in prostate tissue. Toxic effects of ZnCl2 were not recorded in this study. Conclusions: Protective role of zinc was exhibited against toxic effects of cadmium in prostate gland. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 7 3 245 248 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Cadmium Zinc PSA Hyperplasia Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
Cadmium Zinc PSA Hyperplasia Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Abdelkrim Berroukche Mohamed Terras Abdelrahmane Labani Hafsa Dellaoui Wassila Lansari Effects of interaction CdZn on serum-PSA level and prostate histology in rats |
topic_facet |
Cadmium Zinc PSA Hyperplasia Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To assess cadmium sulfate (CdSO4) and zinc chloride (ZnCl2) antagonist effects on the prostate specific antigen and prostatic cell organization in rats. Methods: The study included 40 adult male rats, divided into four groups: Group 1 (CdSO4), Group 2 (ZnCl2), Group 3 (CdSO4ZnCl2) and Group 4 (control). Animals were treated with CdSO4 and ZnCl2 at the same dose (15 mg/L) during 30 days. Results: It was showed a higher body weight and a lowering serum-prostate specific antigen concentration [(1.8 ± 0.6) ng/mL] in animals treated with CdSO4. CdSO4 induced a cyto-nuclear atypia, proliferative lesions, hyperplasia and precancerous foci in prostate tissue. Toxic effects of ZnCl2 were not recorded in this study. Conclusions: Protective role of zinc was exhibited against toxic effects of cadmium in prostate gland. |
format |
Article in Journal/Newspaper |
author |
Abdelkrim Berroukche Mohamed Terras Abdelrahmane Labani Hafsa Dellaoui Wassila Lansari |
author_facet |
Abdelkrim Berroukche Mohamed Terras Abdelrahmane Labani Hafsa Dellaoui Wassila Lansari |
author_sort |
Abdelkrim Berroukche |
title |
Effects of interaction CdZn on serum-PSA level and prostate histology in rats |
title_short |
Effects of interaction CdZn on serum-PSA level and prostate histology in rats |
title_full |
Effects of interaction CdZn on serum-PSA level and prostate histology in rats |
title_fullStr |
Effects of interaction CdZn on serum-PSA level and prostate histology in rats |
title_full_unstemmed |
Effects of interaction CdZn on serum-PSA level and prostate histology in rats |
title_sort |
effects of interaction cdzn on serum-psa level and prostate histology in rats |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2017 |
url |
https://doi.org/10.1016/j.apjtb.2016.12.012 https://doaj.org/article/e49e99ef38824fb5bc6436b8b6c4fe4b |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 7, Iss 3, Pp 245-248 (2017) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169116311418 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2016.12.012 https://doaj.org/article/e49e99ef38824fb5bc6436b8b6c4fe4b |
op_doi |
https://doi.org/10.1016/j.apjtb.2016.12.012 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
7 |
container_issue |
3 |
container_start_page |
245 |
op_container_end_page |
248 |
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1766335108958126080 |