Treatment with benznidazole in association with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi: investigation into the possible development of neoplasias
Benznidazole is recommended in Brazil for the treatment of Trypanosoma cruzi infection in acute and early chronic phases of Chagas' disease. Observations by others have indicated a higher incidence of neoplasias in immunosuppressed patients, presenting Chagas' disease reactivation, submitt...
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Sociedade Brasileira de Medicina Tropical (SBMT)
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ftdoajarticles:oai:doaj.org/article:e45a8cf25cba421ca58fe022a044d977 2023-05-15T15:08:36+02:00 Treatment with benznidazole in association with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi: investigation into the possible development of neoplasias Sonia G. Andrade Igor Marcelo Oliveira Mesquita Jamile F. Jambeiro Isis F. Magalhães Santos Renata Siqueira Portella 2003-07-01T00:00:00Z https://doaj.org/article/e45a8cf25cba421ca58fe022a044d977 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822003000400002&tlng=en https://doaj.org/toc/1678-9849 1678-9849 https://doaj.org/article/e45a8cf25cba421ca58fe022a044d977 Revista da Sociedade Brasileira de Medicina Tropical, Vol 36, Iss 4, Pp 441-447 (2003) Trypanosoma cruzi Experimental infection Chemotherapy Benznidazole Immunosuppressive drugs Non-Hodgkin's lymphoma Arctic medicine. Tropical medicine RC955-962 article 2003 ftdoajarticles 2022-12-31T02:02:34Z Benznidazole is recommended in Brazil for the treatment of Trypanosoma cruzi infection in acute and early chronic phases of Chagas' disease. Observations by others have indicated a higher incidence of neoplasias in immunosuppressed patients, presenting Chagas' disease reactivation, submitted to treatment with benznidazole. In the present study, we investigated whether there is a potentiation in the generation of lymphomas in chronically infected mice, treated with immunosuppressive drugs and benznidazole. For this, 142 Swiss mice chronically infected with the 21 SF strain of T. cruzi and 72 normal Swiss mice were used. Both infected and normal mice were divided into experimental groups and submitted to one of the following treatment regimens: benznidazole alone; immunosuppressive drugs (azathioprine, betamethasone and cyclosporin); a combination of immunosuppressive drugs and benznidazole; and untreated controls. In the infected group treated with benznidazole, one mouse developed a non-Hodgkin's lymphoma. This finding has been interpreted as a spontaneous tumor of mice. The study of the chronically infected mice treated with the combination of immunosuppressive drugs and benznidazole demonstrated an absence of lymphomas or other neoplasias. These findings support the indication of benznidazole, as the drug of choice, for immunosuppressed patients that develop a reactivation of Chagas' disease. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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Directory of Open Access Journals: DOAJ Articles |
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topic |
Trypanosoma cruzi Experimental infection Chemotherapy Benznidazole Immunosuppressive drugs Non-Hodgkin's lymphoma Arctic medicine. Tropical medicine RC955-962 |
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Trypanosoma cruzi Experimental infection Chemotherapy Benznidazole Immunosuppressive drugs Non-Hodgkin's lymphoma Arctic medicine. Tropical medicine RC955-962 Sonia G. Andrade Igor Marcelo Oliveira Mesquita Jamile F. Jambeiro Isis F. Magalhães Santos Renata Siqueira Portella Treatment with benznidazole in association with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi: investigation into the possible development of neoplasias |
topic_facet |
Trypanosoma cruzi Experimental infection Chemotherapy Benznidazole Immunosuppressive drugs Non-Hodgkin's lymphoma Arctic medicine. Tropical medicine RC955-962 |
description |
Benznidazole is recommended in Brazil for the treatment of Trypanosoma cruzi infection in acute and early chronic phases of Chagas' disease. Observations by others have indicated a higher incidence of neoplasias in immunosuppressed patients, presenting Chagas' disease reactivation, submitted to treatment with benznidazole. In the present study, we investigated whether there is a potentiation in the generation of lymphomas in chronically infected mice, treated with immunosuppressive drugs and benznidazole. For this, 142 Swiss mice chronically infected with the 21 SF strain of T. cruzi and 72 normal Swiss mice were used. Both infected and normal mice were divided into experimental groups and submitted to one of the following treatment regimens: benznidazole alone; immunosuppressive drugs (azathioprine, betamethasone and cyclosporin); a combination of immunosuppressive drugs and benznidazole; and untreated controls. In the infected group treated with benznidazole, one mouse developed a non-Hodgkin's lymphoma. This finding has been interpreted as a spontaneous tumor of mice. The study of the chronically infected mice treated with the combination of immunosuppressive drugs and benznidazole demonstrated an absence of lymphomas or other neoplasias. These findings support the indication of benznidazole, as the drug of choice, for immunosuppressed patients that develop a reactivation of Chagas' disease. |
format |
Article in Journal/Newspaper |
author |
Sonia G. Andrade Igor Marcelo Oliveira Mesquita Jamile F. Jambeiro Isis F. Magalhães Santos Renata Siqueira Portella |
author_facet |
Sonia G. Andrade Igor Marcelo Oliveira Mesquita Jamile F. Jambeiro Isis F. Magalhães Santos Renata Siqueira Portella |
author_sort |
Sonia G. Andrade |
title |
Treatment with benznidazole in association with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi: investigation into the possible development of neoplasias |
title_short |
Treatment with benznidazole in association with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi: investigation into the possible development of neoplasias |
title_full |
Treatment with benznidazole in association with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi: investigation into the possible development of neoplasias |
title_fullStr |
Treatment with benznidazole in association with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi: investigation into the possible development of neoplasias |
title_full_unstemmed |
Treatment with benznidazole in association with immunosuppressive drugs in mice chronically infected with Trypanosoma cruzi: investigation into the possible development of neoplasias |
title_sort |
treatment with benznidazole in association with immunosuppressive drugs in mice chronically infected with trypanosoma cruzi: investigation into the possible development of neoplasias |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2003 |
url |
https://doaj.org/article/e45a8cf25cba421ca58fe022a044d977 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 36, Iss 4, Pp 441-447 (2003) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822003000400002&tlng=en https://doaj.org/toc/1678-9849 1678-9849 https://doaj.org/article/e45a8cf25cba421ca58fe022a044d977 |
_version_ |
1766339931459813376 |