Ethnobotanical database based screening and identification of potential plant species with antiplasmodial activity against chloroquine-sensitive (3D7) strain of Plasmodium falciparum
Objective: To evaluate the antiplasmodial activity of aqueous-methanolic plant extracts of nine plant species selected, based on ethnobotanical data. Methods: Based on ethnobotanical database, the selected plants were tested for their antiplasmodial activity against chloroquine-sensitive (3D7) strai...
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Wolters Kluwer Medknow Publications
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ftdoajarticles:oai:doaj.org/article:e4132d1484ab49bca9bc7bc800a3fecc 2023-05-15T15:05:24+02:00 Ethnobotanical database based screening and identification of potential plant species with antiplasmodial activity against chloroquine-sensitive (3D7) strain of Plasmodium falciparum Monica Noronha Shivali Guleria Dhara Jani L B George Hyacinth Highland R B Subramanian 2018-01-01T00:00:00Z https://doi.org/10.4103/2221-1691.225619 https://doaj.org/article/e4132d1484ab49bca9bc7bc800a3fecc EN eng Wolters Kluwer Medknow Publications http://www.apjtb.org/article.asp?issn=2221-1691;year=2018;volume=8;issue=2;spage=92;epage=97;aulast=Noronha https://doaj.org/toc/2221-1691 2221-1691 doi:10.4103/2221-1691.225619 https://doaj.org/article/e4132d1484ab49bca9bc7bc800a3fecc Asian Pacific Journal of Tropical Biomedicine, Vol 8, Iss 2, Pp 92-97 (2018) antiplasmodial antioxidant plasmodium falciparum ethnobotany Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2018 ftdoajarticles https://doi.org/10.4103/2221-1691.225619 2022-12-31T02:54:38Z Objective: To evaluate the antiplasmodial activity of aqueous-methanolic plant extracts of nine plant species selected, based on ethnobotanical data. Methods: Based on ethnobotanical database, the selected plants were tested for their antiplasmodial activity against chloroquine-sensitive (3D7) strain of Plasmodium falciparum. Qualitative tests and high performance thin layer chromatography analysis were carried out to explore the phytocomponents present in the plant extracts. 1,1-diphenyl-2-picrylhydrazyl antioxidant activity was also determined to check the antioxidant activity of the plant extracts. Results: Moringa oleifera (IC50: 3.906 μg/mL), Acalypha indica (IC50: 3.906 μg/mL), Hyptis suaveolens (IC50: 3.906 μg/mL), Mangifera indica (IC50: 4.150 μg/mL) and Averrhoa bilimbi (IC50: 4.881 μg/mL) showed very good antiplasmodial activity. Conclusions: Crude extracts of Mangifera indica and Hyptis suaveolens demonstrated the most efficacious antimalarial activity. A bioassay-guided fractionation of these extracts to identify the lead compound is proved to be useful. The results validate the traditional use of the selected plants as antimalarials. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 8 2 92 |
institution |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
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language |
English |
topic |
antiplasmodial antioxidant plasmodium falciparum ethnobotany Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
antiplasmodial antioxidant plasmodium falciparum ethnobotany Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Monica Noronha Shivali Guleria Dhara Jani L B George Hyacinth Highland R B Subramanian Ethnobotanical database based screening and identification of potential plant species with antiplasmodial activity against chloroquine-sensitive (3D7) strain of Plasmodium falciparum |
topic_facet |
antiplasmodial antioxidant plasmodium falciparum ethnobotany Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To evaluate the antiplasmodial activity of aqueous-methanolic plant extracts of nine plant species selected, based on ethnobotanical data. Methods: Based on ethnobotanical database, the selected plants were tested for their antiplasmodial activity against chloroquine-sensitive (3D7) strain of Plasmodium falciparum. Qualitative tests and high performance thin layer chromatography analysis were carried out to explore the phytocomponents present in the plant extracts. 1,1-diphenyl-2-picrylhydrazyl antioxidant activity was also determined to check the antioxidant activity of the plant extracts. Results: Moringa oleifera (IC50: 3.906 μg/mL), Acalypha indica (IC50: 3.906 μg/mL), Hyptis suaveolens (IC50: 3.906 μg/mL), Mangifera indica (IC50: 4.150 μg/mL) and Averrhoa bilimbi (IC50: 4.881 μg/mL) showed very good antiplasmodial activity. Conclusions: Crude extracts of Mangifera indica and Hyptis suaveolens demonstrated the most efficacious antimalarial activity. A bioassay-guided fractionation of these extracts to identify the lead compound is proved to be useful. The results validate the traditional use of the selected plants as antimalarials. |
format |
Article in Journal/Newspaper |
author |
Monica Noronha Shivali Guleria Dhara Jani L B George Hyacinth Highland R B Subramanian |
author_facet |
Monica Noronha Shivali Guleria Dhara Jani L B George Hyacinth Highland R B Subramanian |
author_sort |
Monica Noronha |
title |
Ethnobotanical database based screening and identification of potential plant species with antiplasmodial activity against chloroquine-sensitive (3D7) strain of Plasmodium falciparum |
title_short |
Ethnobotanical database based screening and identification of potential plant species with antiplasmodial activity against chloroquine-sensitive (3D7) strain of Plasmodium falciparum |
title_full |
Ethnobotanical database based screening and identification of potential plant species with antiplasmodial activity against chloroquine-sensitive (3D7) strain of Plasmodium falciparum |
title_fullStr |
Ethnobotanical database based screening and identification of potential plant species with antiplasmodial activity against chloroquine-sensitive (3D7) strain of Plasmodium falciparum |
title_full_unstemmed |
Ethnobotanical database based screening and identification of potential plant species with antiplasmodial activity against chloroquine-sensitive (3D7) strain of Plasmodium falciparum |
title_sort |
ethnobotanical database based screening and identification of potential plant species with antiplasmodial activity against chloroquine-sensitive (3d7) strain of plasmodium falciparum |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2018 |
url |
https://doi.org/10.4103/2221-1691.225619 https://doaj.org/article/e4132d1484ab49bca9bc7bc800a3fecc |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 8, Iss 2, Pp 92-97 (2018) |
op_relation |
http://www.apjtb.org/article.asp?issn=2221-1691;year=2018;volume=8;issue=2;spage=92;epage=97;aulast=Noronha https://doaj.org/toc/2221-1691 2221-1691 doi:10.4103/2221-1691.225619 https://doaj.org/article/e4132d1484ab49bca9bc7bc800a3fecc |
op_doi |
https://doi.org/10.4103/2221-1691.225619 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
8 |
container_issue |
2 |
container_start_page |
92 |
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1766337108043104256 |