Facial structure alterations and abnormalities of the paranasal sinuses on multidetector computed tomography scans of patients with treated mucosal leishmaniasis.
BACKGROUND/OBJECTIVES: Mucosal leishmaniasis (ML) is a progressive disease that affects cartilage and bone structures of the nose and other upper respiratory tract structures. Complications associated with ML have been described, but there is a lack of studies that evaluate the structural changes of...
Published in: | PLoS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0003001 https://doaj.org/article/e4078e4ff40143748ce26376ba8336a1 |
id |
ftdoajarticles:oai:doaj.org/article:e4078e4ff40143748ce26376ba8336a1 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:e4078e4ff40143748ce26376ba8336a1 2023-05-15T15:16:36+02:00 Facial structure alterations and abnormalities of the paranasal sinuses on multidetector computed tomography scans of patients with treated mucosal leishmaniasis. Raphael Abegão de Camargo Antonio C Nicodemo Daniel Vaccaro Sumi Eloisa Maria Mello Santiago Gebrim Felipe Francisco Tuon Lázaro Manoel de Camargo Rui Imamura Valdir Sabbaga Amato 2014-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0003001 https://doaj.org/article/e4078e4ff40143748ce26376ba8336a1 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4117457?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003001 https://doaj.org/article/e4078e4ff40143748ce26376ba8336a1 PLoS Neglected Tropical Diseases, Vol 8, Iss 7, p e3001 (2014) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2014 ftdoajarticles https://doi.org/10.1371/journal.pntd.0003001 2022-12-31T12:24:11Z BACKGROUND/OBJECTIVES: Mucosal leishmaniasis (ML) is a progressive disease that affects cartilage and bone structures of the nose and other upper respiratory tract structures. Complications associated with ML have been described, but there is a lack of studies that evaluate the structural changes of the nose and paranasal sinuses in ML using radiological methods. In this study, we aimed to assess the opacification of the paranasal sinuses in patients with treated ML and any anatomical changes in the face associated with ML using multidetector computed tomography scans (MDCT) of the sinuses. We compared the findings with a control group. METHODOLOGY/PRINCIPAL FINDINGS: We evaluated 54 patients with treated ML who underwent CT scans of the sinuses and compared them with a control group of 40 patients who underwent orbital CT scans. The degree of sinus disease was assessed according to the Lund-Mackay criteria. Forty of the 54 patients with a history of ML (74.1%) had a tomographic score compatible with chronic sinusitis (Lund-Mackay ≥4). CT scans in the leishmaniasis and control groups demonstrated significant differences in terms of facial structure alterations. Patients from the ML group showed more severe levels of partial opacification and pansinus mucosal thickening (42.6%) and a greater severity of total opacification. Patients from the ML group with a Lund-Mackay score ≥4 presented longer durations of disease before treatment and more severe presentations of the disease at diagnosis. CONCLUSION/SIGNIFICANCE: CT scans of the sinuses of patients with ML presented several structural alterations, revealing a prominent destructive feature of the disease. The higher prevalence in this study of chronic rhinosinusitis observed in CT scans of patients with treated ML than in those of the control group suggests that ML can be considered a risk factor for chronic rhinosinusitis in this population (p<0.05). Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Mackay ENVELOPE(168.517,168.517,-77.700,-77.700) PLoS Neglected Tropical Diseases 8 7 e3001 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Raphael Abegão de Camargo Antonio C Nicodemo Daniel Vaccaro Sumi Eloisa Maria Mello Santiago Gebrim Felipe Francisco Tuon Lázaro Manoel de Camargo Rui Imamura Valdir Sabbaga Amato Facial structure alterations and abnormalities of the paranasal sinuses on multidetector computed tomography scans of patients with treated mucosal leishmaniasis. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND/OBJECTIVES: Mucosal leishmaniasis (ML) is a progressive disease that affects cartilage and bone structures of the nose and other upper respiratory tract structures. Complications associated with ML have been described, but there is a lack of studies that evaluate the structural changes of the nose and paranasal sinuses in ML using radiological methods. In this study, we aimed to assess the opacification of the paranasal sinuses in patients with treated ML and any anatomical changes in the face associated with ML using multidetector computed tomography scans (MDCT) of the sinuses. We compared the findings with a control group. METHODOLOGY/PRINCIPAL FINDINGS: We evaluated 54 patients with treated ML who underwent CT scans of the sinuses and compared them with a control group of 40 patients who underwent orbital CT scans. The degree of sinus disease was assessed according to the Lund-Mackay criteria. Forty of the 54 patients with a history of ML (74.1%) had a tomographic score compatible with chronic sinusitis (Lund-Mackay ≥4). CT scans in the leishmaniasis and control groups demonstrated significant differences in terms of facial structure alterations. Patients from the ML group showed more severe levels of partial opacification and pansinus mucosal thickening (42.6%) and a greater severity of total opacification. Patients from the ML group with a Lund-Mackay score ≥4 presented longer durations of disease before treatment and more severe presentations of the disease at diagnosis. CONCLUSION/SIGNIFICANCE: CT scans of the sinuses of patients with ML presented several structural alterations, revealing a prominent destructive feature of the disease. The higher prevalence in this study of chronic rhinosinusitis observed in CT scans of patients with treated ML than in those of the control group suggests that ML can be considered a risk factor for chronic rhinosinusitis in this population (p<0.05). |
format |
Article in Journal/Newspaper |
author |
Raphael Abegão de Camargo Antonio C Nicodemo Daniel Vaccaro Sumi Eloisa Maria Mello Santiago Gebrim Felipe Francisco Tuon Lázaro Manoel de Camargo Rui Imamura Valdir Sabbaga Amato |
author_facet |
Raphael Abegão de Camargo Antonio C Nicodemo Daniel Vaccaro Sumi Eloisa Maria Mello Santiago Gebrim Felipe Francisco Tuon Lázaro Manoel de Camargo Rui Imamura Valdir Sabbaga Amato |
author_sort |
Raphael Abegão de Camargo |
title |
Facial structure alterations and abnormalities of the paranasal sinuses on multidetector computed tomography scans of patients with treated mucosal leishmaniasis. |
title_short |
Facial structure alterations and abnormalities of the paranasal sinuses on multidetector computed tomography scans of patients with treated mucosal leishmaniasis. |
title_full |
Facial structure alterations and abnormalities of the paranasal sinuses on multidetector computed tomography scans of patients with treated mucosal leishmaniasis. |
title_fullStr |
Facial structure alterations and abnormalities of the paranasal sinuses on multidetector computed tomography scans of patients with treated mucosal leishmaniasis. |
title_full_unstemmed |
Facial structure alterations and abnormalities of the paranasal sinuses on multidetector computed tomography scans of patients with treated mucosal leishmaniasis. |
title_sort |
facial structure alterations and abnormalities of the paranasal sinuses on multidetector computed tomography scans of patients with treated mucosal leishmaniasis. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2014 |
url |
https://doi.org/10.1371/journal.pntd.0003001 https://doaj.org/article/e4078e4ff40143748ce26376ba8336a1 |
long_lat |
ENVELOPE(168.517,168.517,-77.700,-77.700) |
geographic |
Arctic Mackay |
geographic_facet |
Arctic Mackay |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 8, Iss 7, p e3001 (2014) |
op_relation |
http://europepmc.org/articles/PMC4117457?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003001 https://doaj.org/article/e4078e4ff40143748ce26376ba8336a1 |
op_doi |
https://doi.org/10.1371/journal.pntd.0003001 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
8 |
container_issue |
7 |
container_start_page |
e3001 |
_version_ |
1766346893990821888 |