Exposome-wide ranking of modifiable risk factors for cardiometabolic disease traits
Abstract The present study assessed the temporal associations of ~ 300 lifestyle exposures with nine cardiometabolic traits to identify exposures/exposure groups that might inform lifestyle interventions for the reduction of cardiometabolic disease risk. The analyses were undertaken in a longitudina...
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2022
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ftdoajarticles:oai:doaj.org/article:e3d9715821e4496c9edb2c7a5851b0dc 2023-05-15T17:44:44+02:00 Exposome-wide ranking of modifiable risk factors for cardiometabolic disease traits Alaitz Poveda Hugo Pomares-Millan Yan Chen Azra Kurbasic Chirag J. Patel Frida Renström Göran Hallmans Ingegerd Johansson Paul W. Franks 2022-03-01T00:00:00Z https://doi.org/10.1038/s41598-022-08050-1 https://doaj.org/article/e3d9715821e4496c9edb2c7a5851b0dc EN eng Nature Portfolio https://doi.org/10.1038/s41598-022-08050-1 https://doaj.org/toc/2045-2322 doi:10.1038/s41598-022-08050-1 2045-2322 https://doaj.org/article/e3d9715821e4496c9edb2c7a5851b0dc Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022) Medicine R Science Q article 2022 ftdoajarticles https://doi.org/10.1038/s41598-022-08050-1 2022-12-31T15:40:37Z Abstract The present study assessed the temporal associations of ~ 300 lifestyle exposures with nine cardiometabolic traits to identify exposures/exposure groups that might inform lifestyle interventions for the reduction of cardiometabolic disease risk. The analyses were undertaken in a longitudinal sample comprising > 31,000 adults living in northern Sweden. Linear mixed models were used to assess the average associations of lifestyle exposures and linear regression models were used to test associations with 10-year change in the cardiometabolic traits. ‘Physical activity’ and ‘General Health’ were the exposure categories containing the highest number of ‘tentative signals’ in analyses assessing the average association of lifestyle variables, while ‘Tobacco use’ was the top category for the 10-year change association analyses. Eleven modifiable variables showed a consistent average association among the majority of cardiometabolic traits. These variables belonged to the domains: (i) Smoking, (ii) Beverage (filtered coffee), (iii) physical activity, (iv) alcohol intake, and (v) specific variables related to Nordic lifestyle (hunting/fishing during leisure time and boiled coffee consumption). We used an agnostic, data-driven approach to assess a wide range of established and novel risk factors for cardiometabolic disease. Our findings highlight key variables, along with their respective effect estimates, that might be prioritised for subsequent prediction models and lifestyle interventions. Article in Journal/Newspaper Northern Sweden Directory of Open Access Journals: DOAJ Articles Scientific Reports 12 1 |
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Medicine R Science Q Alaitz Poveda Hugo Pomares-Millan Yan Chen Azra Kurbasic Chirag J. Patel Frida Renström Göran Hallmans Ingegerd Johansson Paul W. Franks Exposome-wide ranking of modifiable risk factors for cardiometabolic disease traits |
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Medicine R Science Q |
description |
Abstract The present study assessed the temporal associations of ~ 300 lifestyle exposures with nine cardiometabolic traits to identify exposures/exposure groups that might inform lifestyle interventions for the reduction of cardiometabolic disease risk. The analyses were undertaken in a longitudinal sample comprising > 31,000 adults living in northern Sweden. Linear mixed models were used to assess the average associations of lifestyle exposures and linear regression models were used to test associations with 10-year change in the cardiometabolic traits. ‘Physical activity’ and ‘General Health’ were the exposure categories containing the highest number of ‘tentative signals’ in analyses assessing the average association of lifestyle variables, while ‘Tobacco use’ was the top category for the 10-year change association analyses. Eleven modifiable variables showed a consistent average association among the majority of cardiometabolic traits. These variables belonged to the domains: (i) Smoking, (ii) Beverage (filtered coffee), (iii) physical activity, (iv) alcohol intake, and (v) specific variables related to Nordic lifestyle (hunting/fishing during leisure time and boiled coffee consumption). We used an agnostic, data-driven approach to assess a wide range of established and novel risk factors for cardiometabolic disease. Our findings highlight key variables, along with their respective effect estimates, that might be prioritised for subsequent prediction models and lifestyle interventions. |
format |
Article in Journal/Newspaper |
author |
Alaitz Poveda Hugo Pomares-Millan Yan Chen Azra Kurbasic Chirag J. Patel Frida Renström Göran Hallmans Ingegerd Johansson Paul W. Franks |
author_facet |
Alaitz Poveda Hugo Pomares-Millan Yan Chen Azra Kurbasic Chirag J. Patel Frida Renström Göran Hallmans Ingegerd Johansson Paul W. Franks |
author_sort |
Alaitz Poveda |
title |
Exposome-wide ranking of modifiable risk factors for cardiometabolic disease traits |
title_short |
Exposome-wide ranking of modifiable risk factors for cardiometabolic disease traits |
title_full |
Exposome-wide ranking of modifiable risk factors for cardiometabolic disease traits |
title_fullStr |
Exposome-wide ranking of modifiable risk factors for cardiometabolic disease traits |
title_full_unstemmed |
Exposome-wide ranking of modifiable risk factors for cardiometabolic disease traits |
title_sort |
exposome-wide ranking of modifiable risk factors for cardiometabolic disease traits |
publisher |
Nature Portfolio |
publishDate |
2022 |
url |
https://doi.org/10.1038/s41598-022-08050-1 https://doaj.org/article/e3d9715821e4496c9edb2c7a5851b0dc |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022) |
op_relation |
https://doi.org/10.1038/s41598-022-08050-1 https://doaj.org/toc/2045-2322 doi:10.1038/s41598-022-08050-1 2045-2322 https://doaj.org/article/e3d9715821e4496c9edb2c7a5851b0dc |
op_doi |
https://doi.org/10.1038/s41598-022-08050-1 |
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Scientific Reports |
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12 |
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1 |
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1766147015262076928 |