Humanized DRAGA mice immunized with Plasmodium falciparum sporozoites and chloroquine elicit protective pre-erythrocytic immunity

• Published in: Malaria Journal
• Main Authors: Sai Majji, Wathsala Wijayalath, Soumya Shashikumar, Teodor D. Brumeanu, Sofia Casares
• Format: Article in Journal/Newspaper
• Language: English
• Published: BMC 2018
• Subjects: Humanized DRAGA mice; Plasmodium falciparum; Malaria; Human T cells; Antibodies; Chloroquine; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic; Draga
• Online Access: https://doi.org/10.1186/s12936-018-2264-y; https://doaj.org/article/e3d94b4a6fba415f85dabb98132ed839

Abstract Background Human-immune-system humanized mouse models can bridge the gap between humans and conventional mice for testing human vaccines. The HLA-expressing humanized DRAGA (HLA-A2.HLA-DR4.Rag1KO.IL2RγcKO.NOD) mice reconstitute a functional human-immune-system and sustain the complete life...