Seasonal and regional dynamics of M. ulcerans transmission in environmental context: deciphering the role of water bugs as hosts and vectors.
BACKGROUND:Buruli ulcer, the third mycobacterial disease after tuberculosis and leprosy, is caused by the environmental mycobacterium M. ulcerans. Various modes of transmission have been suspected for this disease, with no general consensus acceptance for any of them up to now. Since laboratory mode...
Published in: | PLoS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2010
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0000731 https://doaj.org/article/e35386d7268a4feba95f4762a9419d12 |
id |
ftdoajarticles:oai:doaj.org/article:e35386d7268a4feba95f4762a9419d12 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:e35386d7268a4feba95f4762a9419d12 2023-05-15T15:16:30+02:00 Seasonal and regional dynamics of M. ulcerans transmission in environmental context: deciphering the role of water bugs as hosts and vectors. Estelle Marion Sara Eyangoh Edouard Yeramian Julien Doannio Jordi Landier Jacques Aubry Arnaud Fontanet Christophe Rogier Viviane Cassisa Jane Cottin Agnès Marot Matthieu Eveillard Yannick Kamdem Pierre Legras Caroline Deshayes Jean-Paul Saint-André Laurent Marsollier 2010-07-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000731 https://doaj.org/article/e35386d7268a4feba95f4762a9419d12 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC2897839?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000731 https://doaj.org/article/e35386d7268a4feba95f4762a9419d12 PLoS Neglected Tropical Diseases, Vol 4, Iss 7, p e731 (2010) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2010 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000731 2022-12-31T14:15:41Z BACKGROUND:Buruli ulcer, the third mycobacterial disease after tuberculosis and leprosy, is caused by the environmental mycobacterium M. ulcerans. Various modes of transmission have been suspected for this disease, with no general consensus acceptance for any of them up to now. Since laboratory models demonstrated the ability of water bugs to transmit M. ulcerans, a particular attention is focused on the transmission of the bacilli by water bugs as hosts and vectors. However, it is only through detailed knowledge of the biodiversity and ecology of water bugs that the importance of this mode of transmission can be fully assessed. It is the objective of the work here to decipher the role of water bugs in M. ulcerans ecology and transmission, based on large-scale field studies. METHODOLOGY/PRINCIPAL FINDINGS:The distribution of M. ulcerans-hosting water bugs was monitored on previously unprecedented time and space scales: a total of 7,407 water bugs, belonging to large number of different families, were collected over one year, in Buruli ulcer endemic and non endemic areas in central Cameroon. This study demonstrated the presence of M. ulcerans in insect saliva. In addition, the field results provided a full picture of the ecology of transmission in terms of biodiversity and detailed specification of seasonal and regional dynamics, with large temporal heterogeneity in the insect tissue colonization rate and detection of M. ulcerans only in water bug tissues collected in Buruli ulcer endemic areas. CONCLUSION/SIGNIFICANCE:The large-scale detection of bacilli in saliva of biting water bugs gives enhanced weight to their role in M. ulcerans transmission. On practical grounds, beyond the ecological interest, the results concerning seasonal and regional dynamics can provide an efficient tool in the hands of sanitary authorities to monitor environmental risks associated with Buruli ulcer. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 4 7 e731 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Estelle Marion Sara Eyangoh Edouard Yeramian Julien Doannio Jordi Landier Jacques Aubry Arnaud Fontanet Christophe Rogier Viviane Cassisa Jane Cottin Agnès Marot Matthieu Eveillard Yannick Kamdem Pierre Legras Caroline Deshayes Jean-Paul Saint-André Laurent Marsollier Seasonal and regional dynamics of M. ulcerans transmission in environmental context: deciphering the role of water bugs as hosts and vectors. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:Buruli ulcer, the third mycobacterial disease after tuberculosis and leprosy, is caused by the environmental mycobacterium M. ulcerans. Various modes of transmission have been suspected for this disease, with no general consensus acceptance for any of them up to now. Since laboratory models demonstrated the ability of water bugs to transmit M. ulcerans, a particular attention is focused on the transmission of the bacilli by water bugs as hosts and vectors. However, it is only through detailed knowledge of the biodiversity and ecology of water bugs that the importance of this mode of transmission can be fully assessed. It is the objective of the work here to decipher the role of water bugs in M. ulcerans ecology and transmission, based on large-scale field studies. METHODOLOGY/PRINCIPAL FINDINGS:The distribution of M. ulcerans-hosting water bugs was monitored on previously unprecedented time and space scales: a total of 7,407 water bugs, belonging to large number of different families, were collected over one year, in Buruli ulcer endemic and non endemic areas in central Cameroon. This study demonstrated the presence of M. ulcerans in insect saliva. In addition, the field results provided a full picture of the ecology of transmission in terms of biodiversity and detailed specification of seasonal and regional dynamics, with large temporal heterogeneity in the insect tissue colonization rate and detection of M. ulcerans only in water bug tissues collected in Buruli ulcer endemic areas. CONCLUSION/SIGNIFICANCE:The large-scale detection of bacilli in saliva of biting water bugs gives enhanced weight to their role in M. ulcerans transmission. On practical grounds, beyond the ecological interest, the results concerning seasonal and regional dynamics can provide an efficient tool in the hands of sanitary authorities to monitor environmental risks associated with Buruli ulcer. |
format |
Article in Journal/Newspaper |
author |
Estelle Marion Sara Eyangoh Edouard Yeramian Julien Doannio Jordi Landier Jacques Aubry Arnaud Fontanet Christophe Rogier Viviane Cassisa Jane Cottin Agnès Marot Matthieu Eveillard Yannick Kamdem Pierre Legras Caroline Deshayes Jean-Paul Saint-André Laurent Marsollier |
author_facet |
Estelle Marion Sara Eyangoh Edouard Yeramian Julien Doannio Jordi Landier Jacques Aubry Arnaud Fontanet Christophe Rogier Viviane Cassisa Jane Cottin Agnès Marot Matthieu Eveillard Yannick Kamdem Pierre Legras Caroline Deshayes Jean-Paul Saint-André Laurent Marsollier |
author_sort |
Estelle Marion |
title |
Seasonal and regional dynamics of M. ulcerans transmission in environmental context: deciphering the role of water bugs as hosts and vectors. |
title_short |
Seasonal and regional dynamics of M. ulcerans transmission in environmental context: deciphering the role of water bugs as hosts and vectors. |
title_full |
Seasonal and regional dynamics of M. ulcerans transmission in environmental context: deciphering the role of water bugs as hosts and vectors. |
title_fullStr |
Seasonal and regional dynamics of M. ulcerans transmission in environmental context: deciphering the role of water bugs as hosts and vectors. |
title_full_unstemmed |
Seasonal and regional dynamics of M. ulcerans transmission in environmental context: deciphering the role of water bugs as hosts and vectors. |
title_sort |
seasonal and regional dynamics of m. ulcerans transmission in environmental context: deciphering the role of water bugs as hosts and vectors. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2010 |
url |
https://doi.org/10.1371/journal.pntd.0000731 https://doaj.org/article/e35386d7268a4feba95f4762a9419d12 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 4, Iss 7, p e731 (2010) |
op_relation |
http://europepmc.org/articles/PMC2897839?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000731 https://doaj.org/article/e35386d7268a4feba95f4762a9419d12 |
op_doi |
https://doi.org/10.1371/journal.pntd.0000731 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
4 |
container_issue |
7 |
container_start_page |
e731 |
_version_ |
1766346793022390272 |