Mapping environmental suitability of Haemagogus and Sabethes spp. mosquitoes to understand sylvatic transmission risk of yellow fever virus in Brazil.
Background Yellow fever (YF) is an arboviral disease which is endemic to Brazil due to a sylvatic transmission cycle maintained by infected mosquito vectors, non-human primate (NHP) hosts, and humans. Despite the existence of an effective vaccine, recent sporadic YF epidemics have underscored concer...
Published in: | PLOS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2022
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0010019 https://doaj.org/article/e2ec306290be491f8d18c7e93a3e4c92 |
id |
ftdoajarticles:oai:doaj.org/article:e2ec306290be491f8d18c7e93a3e4c92 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:e2ec306290be491f8d18c7e93a3e4c92 2023-05-15T15:13:17+02:00 Mapping environmental suitability of Haemagogus and Sabethes spp. mosquitoes to understand sylvatic transmission risk of yellow fever virus in Brazil. Sabrina L Li André L Acosta Sarah C Hill Oliver J Brady Marco A B de Almeida Jader da C Cardoso Arran Hamlet Luis F Mucci Juliana Telles de Deus Felipe C M Iani Neil S Alexander G R William Wint Oliver G Pybus Moritz U G Kraemer Nuno R Faria Jane P Messina 2022-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0010019 https://doaj.org/article/e2ec306290be491f8d18c7e93a3e4c92 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0010019 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010019 https://doaj.org/article/e2ec306290be491f8d18c7e93a3e4c92 PLoS Neglected Tropical Diseases, Vol 16, Iss 1, p e0010019 (2022) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2022 ftdoajarticles https://doi.org/10.1371/journal.pntd.0010019 2023-02-26T01:32:20Z Background Yellow fever (YF) is an arboviral disease which is endemic to Brazil due to a sylvatic transmission cycle maintained by infected mosquito vectors, non-human primate (NHP) hosts, and humans. Despite the existence of an effective vaccine, recent sporadic YF epidemics have underscored concerns about sylvatic vector surveillance, as very little is known about their spatial distribution. Here, we model and map the environmental suitability of YF's main vectors in Brazil, Haemagogus spp. and Sabethes spp., and use human population and NHP data to identify locations prone to transmission and spillover risk. Methodology/principal findings We compiled a comprehensive set of occurrence records on Hg. janthinomys, Hg. leucocelaenus, and Sabethes spp. from 1991-2019 using primary and secondary data sources. Linking these data with selected environmental and land-cover variables, we adopted a stacked regression ensemble modelling approach (elastic-net regularized GLM, extreme gradient boosted regression trees, and random forest) to predict the environmental suitability of these species across Brazil at a 1 km x 1 km resolution. We show that while suitability for each species varies spatially, high suitability for all species was predicted in the Southeastern region where recent outbreaks have occurred. By integrating data on NHP host reservoirs and human populations, our risk maps further highlight municipalities within the region that are prone to transmission and spillover. Conclusions/significance Our maps of sylvatic vector suitability can help elucidate potential locations of sylvatic reservoirs and be used as a tool to help mitigate risk of future YF outbreaks and assist in vector surveillance. Furthermore, at-risk regions identified from our work could help disease control and elucidate gaps in vaccination coverage and NHP host surveillance. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 16 1 e0010019 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Sabrina L Li André L Acosta Sarah C Hill Oliver J Brady Marco A B de Almeida Jader da C Cardoso Arran Hamlet Luis F Mucci Juliana Telles de Deus Felipe C M Iani Neil S Alexander G R William Wint Oliver G Pybus Moritz U G Kraemer Nuno R Faria Jane P Messina Mapping environmental suitability of Haemagogus and Sabethes spp. mosquitoes to understand sylvatic transmission risk of yellow fever virus in Brazil. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Yellow fever (YF) is an arboviral disease which is endemic to Brazil due to a sylvatic transmission cycle maintained by infected mosquito vectors, non-human primate (NHP) hosts, and humans. Despite the existence of an effective vaccine, recent sporadic YF epidemics have underscored concerns about sylvatic vector surveillance, as very little is known about their spatial distribution. Here, we model and map the environmental suitability of YF's main vectors in Brazil, Haemagogus spp. and Sabethes spp., and use human population and NHP data to identify locations prone to transmission and spillover risk. Methodology/principal findings We compiled a comprehensive set of occurrence records on Hg. janthinomys, Hg. leucocelaenus, and Sabethes spp. from 1991-2019 using primary and secondary data sources. Linking these data with selected environmental and land-cover variables, we adopted a stacked regression ensemble modelling approach (elastic-net regularized GLM, extreme gradient boosted regression trees, and random forest) to predict the environmental suitability of these species across Brazil at a 1 km x 1 km resolution. We show that while suitability for each species varies spatially, high suitability for all species was predicted in the Southeastern region where recent outbreaks have occurred. By integrating data on NHP host reservoirs and human populations, our risk maps further highlight municipalities within the region that are prone to transmission and spillover. Conclusions/significance Our maps of sylvatic vector suitability can help elucidate potential locations of sylvatic reservoirs and be used as a tool to help mitigate risk of future YF outbreaks and assist in vector surveillance. Furthermore, at-risk regions identified from our work could help disease control and elucidate gaps in vaccination coverage and NHP host surveillance. |
format |
Article in Journal/Newspaper |
author |
Sabrina L Li André L Acosta Sarah C Hill Oliver J Brady Marco A B de Almeida Jader da C Cardoso Arran Hamlet Luis F Mucci Juliana Telles de Deus Felipe C M Iani Neil S Alexander G R William Wint Oliver G Pybus Moritz U G Kraemer Nuno R Faria Jane P Messina |
author_facet |
Sabrina L Li André L Acosta Sarah C Hill Oliver J Brady Marco A B de Almeida Jader da C Cardoso Arran Hamlet Luis F Mucci Juliana Telles de Deus Felipe C M Iani Neil S Alexander G R William Wint Oliver G Pybus Moritz U G Kraemer Nuno R Faria Jane P Messina |
author_sort |
Sabrina L Li |
title |
Mapping environmental suitability of Haemagogus and Sabethes spp. mosquitoes to understand sylvatic transmission risk of yellow fever virus in Brazil. |
title_short |
Mapping environmental suitability of Haemagogus and Sabethes spp. mosquitoes to understand sylvatic transmission risk of yellow fever virus in Brazil. |
title_full |
Mapping environmental suitability of Haemagogus and Sabethes spp. mosquitoes to understand sylvatic transmission risk of yellow fever virus in Brazil. |
title_fullStr |
Mapping environmental suitability of Haemagogus and Sabethes spp. mosquitoes to understand sylvatic transmission risk of yellow fever virus in Brazil. |
title_full_unstemmed |
Mapping environmental suitability of Haemagogus and Sabethes spp. mosquitoes to understand sylvatic transmission risk of yellow fever virus in Brazil. |
title_sort |
mapping environmental suitability of haemagogus and sabethes spp. mosquitoes to understand sylvatic transmission risk of yellow fever virus in brazil. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2022 |
url |
https://doi.org/10.1371/journal.pntd.0010019 https://doaj.org/article/e2ec306290be491f8d18c7e93a3e4c92 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 16, Iss 1, p e0010019 (2022) |
op_relation |
https://doi.org/10.1371/journal.pntd.0010019 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010019 https://doaj.org/article/e2ec306290be491f8d18c7e93a3e4c92 |
op_doi |
https://doi.org/10.1371/journal.pntd.0010019 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
16 |
container_issue |
1 |
container_start_page |
e0010019 |
_version_ |
1766343854484619264 |