Melioidosis in the remote Katherine region of northern Australia.
Melioidosis is endemic in the remote Katherine region of northern Australia. In a population with high rates of chronic disease, social inequities, and extreme remoteness, the impact of melioidosis is exacerbated by severe weather events and disproportionately affects First Nations Australians. All...
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ftdoajarticles:oai:doaj.org/article:e2e07fb58c6241578e96ecfe5b627be9 2023-05-15T15:13:05+02:00 Melioidosis in the remote Katherine region of northern Australia. Kay Hodgetts Mariana Kleinecke Celeste Woerle Mirjam Kaestli Richard Budd Jessica R Webb Linda Ward Mark Mayo Bart J Currie Ella M Meumann 2022-06-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0010486 https://doaj.org/article/e2e07fb58c6241578e96ecfe5b627be9 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0010486 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010486 https://doaj.org/article/e2e07fb58c6241578e96ecfe5b627be9 PLoS Neglected Tropical Diseases, Vol 16, Iss 6, p e0010486 (2022) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2022 ftdoajarticles https://doi.org/10.1371/journal.pntd.0010486 2022-12-30T22:22:01Z Melioidosis is endemic in the remote Katherine region of northern Australia. In a population with high rates of chronic disease, social inequities, and extreme remoteness, the impact of melioidosis is exacerbated by severe weather events and disproportionately affects First Nations Australians. All culture-confirmed melioidosis cases in the Katherine region of the Australian Top End between 1989-2021 were included in the study, and the clinical features and epidemiology were described. The diversity of Burkholderia pseudomallei strains in the region was investigated using genomic sequencing. From 1989-2021 there were 128 patients with melioidosis in the Katherine region. 96/128 (75%) patients were First Nations Australians, 72/128 (56%) were from a very remote region, 68/128 (53%) had diabetes, 57/128 (44%) had a history of hazardous alcohol consumption, and 11/128 (9%) died from melioidosis. There were 9 melioidosis cases attributable to the flooding of the Katherine River in January 1998; 7/9 flood-associated cases had cutaneous melioidosis, five of whom recalled an inoculating event injury sustained wading through flood waters or cleaning up after the flood. The 126 first-episode clinical B. pseudomallei isolates that underwent genomic sequencing belonged to 107 different sequence types and were highly diverse, reflecting the vast geographic area of the study region. In conclusion, melioidosis in the Katherine region disproportionately affects First Nations Australians with risk factors and is exacerbated by severe weather events. Diabetes management, public health intervention for hazardous alcohol consumption, provision of housing to address homelessness, and patient education on melioidosis prevention in First Nations languages should be prioritised. Article in Journal/Newspaper Arctic First Nations Directory of Open Access Journals: DOAJ Articles Arctic Katherine River ENVELOPE(-64.065,-64.065,59.384,59.384) PLOS Neglected Tropical Diseases 16 6 e0010486 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Kay Hodgetts Mariana Kleinecke Celeste Woerle Mirjam Kaestli Richard Budd Jessica R Webb Linda Ward Mark Mayo Bart J Currie Ella M Meumann Melioidosis in the remote Katherine region of northern Australia. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Melioidosis is endemic in the remote Katherine region of northern Australia. In a population with high rates of chronic disease, social inequities, and extreme remoteness, the impact of melioidosis is exacerbated by severe weather events and disproportionately affects First Nations Australians. All culture-confirmed melioidosis cases in the Katherine region of the Australian Top End between 1989-2021 were included in the study, and the clinical features and epidemiology were described. The diversity of Burkholderia pseudomallei strains in the region was investigated using genomic sequencing. From 1989-2021 there were 128 patients with melioidosis in the Katherine region. 96/128 (75%) patients were First Nations Australians, 72/128 (56%) were from a very remote region, 68/128 (53%) had diabetes, 57/128 (44%) had a history of hazardous alcohol consumption, and 11/128 (9%) died from melioidosis. There were 9 melioidosis cases attributable to the flooding of the Katherine River in January 1998; 7/9 flood-associated cases had cutaneous melioidosis, five of whom recalled an inoculating event injury sustained wading through flood waters or cleaning up after the flood. The 126 first-episode clinical B. pseudomallei isolates that underwent genomic sequencing belonged to 107 different sequence types and were highly diverse, reflecting the vast geographic area of the study region. In conclusion, melioidosis in the Katherine region disproportionately affects First Nations Australians with risk factors and is exacerbated by severe weather events. Diabetes management, public health intervention for hazardous alcohol consumption, provision of housing to address homelessness, and patient education on melioidosis prevention in First Nations languages should be prioritised. |
format |
Article in Journal/Newspaper |
author |
Kay Hodgetts Mariana Kleinecke Celeste Woerle Mirjam Kaestli Richard Budd Jessica R Webb Linda Ward Mark Mayo Bart J Currie Ella M Meumann |
author_facet |
Kay Hodgetts Mariana Kleinecke Celeste Woerle Mirjam Kaestli Richard Budd Jessica R Webb Linda Ward Mark Mayo Bart J Currie Ella M Meumann |
author_sort |
Kay Hodgetts |
title |
Melioidosis in the remote Katherine region of northern Australia. |
title_short |
Melioidosis in the remote Katherine region of northern Australia. |
title_full |
Melioidosis in the remote Katherine region of northern Australia. |
title_fullStr |
Melioidosis in the remote Katherine region of northern Australia. |
title_full_unstemmed |
Melioidosis in the remote Katherine region of northern Australia. |
title_sort |
melioidosis in the remote katherine region of northern australia. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2022 |
url |
https://doi.org/10.1371/journal.pntd.0010486 https://doaj.org/article/e2e07fb58c6241578e96ecfe5b627be9 |
long_lat |
ENVELOPE(-64.065,-64.065,59.384,59.384) |
geographic |
Arctic Katherine River |
geographic_facet |
Arctic Katherine River |
genre |
Arctic First Nations |
genre_facet |
Arctic First Nations |
op_source |
PLoS Neglected Tropical Diseases, Vol 16, Iss 6, p e0010486 (2022) |
op_relation |
https://doi.org/10.1371/journal.pntd.0010486 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010486 https://doaj.org/article/e2e07fb58c6241578e96ecfe5b627be9 |
op_doi |
https://doi.org/10.1371/journal.pntd.0010486 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
16 |
container_issue |
6 |
container_start_page |
e0010486 |
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1766343688763473920 |