Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis.
Antibody responses are thought to play an important role in control of Schistosoma infections, yet little is known about the phenotype and function of B cells in human schistosomiasis. We set out to characterize B cell subsets and B cell responses to B cell receptor and Toll-like receptor 9 stimulat...
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ftdoajarticles:oai:doaj.org/article:e26e231d4abc4bf8bed255d11d2108f4 2023-05-15T15:05:10+02:00 Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis. Lucja A Labuda Ulysse Ateba-Ngoa Eliane Ngoune Feugap Jorn J Heeringa Luciën E P M van der Vlugt Regina B A Pires Ludovic Mewono Peter G Kremsner Menno C van Zelm Ayola A Adegnika Maria Yazdanbakhsh Hermelijn H Smits 2013-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0002094 https://doaj.org/article/e26e231d4abc4bf8bed255d11d2108f4 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3591311?pdf=render https://doaj.org/toc/1935-2735 1935-2735 doi:10.1371/journal.pntd.0002094 https://doaj.org/article/e26e231d4abc4bf8bed255d11d2108f4 PLoS Neglected Tropical Diseases, Vol 7, Iss 3, p e2094 (2013) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2013 ftdoajarticles https://doi.org/10.1371/journal.pntd.0002094 2022-12-31T12:57:53Z Antibody responses are thought to play an important role in control of Schistosoma infections, yet little is known about the phenotype and function of B cells in human schistosomiasis. We set out to characterize B cell subsets and B cell responses to B cell receptor and Toll-like receptor 9 stimulation in Gabonese schoolchildren with Schistosoma haematobium infection. Frequencies of memory B cell (MBC) subsets were increased, whereas naive B cell frequencies were reduced in the schistosome-infected group. At the functional level, isolated B cells from schistosome-infected children showed higher expression of the activation marker CD23 upon stimulation, but lower proliferation and TNF-α production. Importantly, 6-months after 3 rounds of praziquantel treatment, frequencies of naive B cells were increased, MBC frequencies were decreased and with the exception of TNF-α production, B cell responsiveness was restored to what was seen in uninfected children. These data show that S. haematobium infection leads to significant changes in the B cell compartment, both at the phenotypic and functional level. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 7 3 e2094 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Lucja A Labuda Ulysse Ateba-Ngoa Eliane Ngoune Feugap Jorn J Heeringa Luciën E P M van der Vlugt Regina B A Pires Ludovic Mewono Peter G Kremsner Menno C van Zelm Ayola A Adegnika Maria Yazdanbakhsh Hermelijn H Smits Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Antibody responses are thought to play an important role in control of Schistosoma infections, yet little is known about the phenotype and function of B cells in human schistosomiasis. We set out to characterize B cell subsets and B cell responses to B cell receptor and Toll-like receptor 9 stimulation in Gabonese schoolchildren with Schistosoma haematobium infection. Frequencies of memory B cell (MBC) subsets were increased, whereas naive B cell frequencies were reduced in the schistosome-infected group. At the functional level, isolated B cells from schistosome-infected children showed higher expression of the activation marker CD23 upon stimulation, but lower proliferation and TNF-α production. Importantly, 6-months after 3 rounds of praziquantel treatment, frequencies of naive B cells were increased, MBC frequencies were decreased and with the exception of TNF-α production, B cell responsiveness was restored to what was seen in uninfected children. These data show that S. haematobium infection leads to significant changes in the B cell compartment, both at the phenotypic and functional level. |
format |
Article in Journal/Newspaper |
author |
Lucja A Labuda Ulysse Ateba-Ngoa Eliane Ngoune Feugap Jorn J Heeringa Luciën E P M van der Vlugt Regina B A Pires Ludovic Mewono Peter G Kremsner Menno C van Zelm Ayola A Adegnika Maria Yazdanbakhsh Hermelijn H Smits |
author_facet |
Lucja A Labuda Ulysse Ateba-Ngoa Eliane Ngoune Feugap Jorn J Heeringa Luciën E P M van der Vlugt Regina B A Pires Ludovic Mewono Peter G Kremsner Menno C van Zelm Ayola A Adegnika Maria Yazdanbakhsh Hermelijn H Smits |
author_sort |
Lucja A Labuda |
title |
Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis. |
title_short |
Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis. |
title_full |
Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis. |
title_fullStr |
Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis. |
title_full_unstemmed |
Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis. |
title_sort |
alterations in peripheral blood b cell subsets and dynamics of b cell responses during human schistosomiasis. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2013 |
url |
https://doi.org/10.1371/journal.pntd.0002094 https://doaj.org/article/e26e231d4abc4bf8bed255d11d2108f4 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 7, Iss 3, p e2094 (2013) |
op_relation |
http://europepmc.org/articles/PMC3591311?pdf=render https://doaj.org/toc/1935-2735 1935-2735 doi:10.1371/journal.pntd.0002094 https://doaj.org/article/e26e231d4abc4bf8bed255d11d2108f4 |
op_doi |
https://doi.org/10.1371/journal.pntd.0002094 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
7 |
container_issue |
3 |
container_start_page |
e2094 |
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1766336915592708096 |