Reduced schedule of human anti rabies immunization with Fuenzalida & Palacios vaccine

• Published in: Revista do Instituto de Medicina Tropical de São Paulo
• Main Authors: Carlos Roberto Zanetti, Silvana Regina Favoretto, Milene Silva Tino, Avelino Albas, Elizabeth Juliana G. Valentini, Octávio Augusto de C. Pereira
• Format: Article in Journal/Newspaper
• Language: English
• Published: Universidade de São Paulo (USP) 1989
• Subjects: Antirabies vaccination; Reduced schedule; Cellular immunity; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic; Fuenzalida
• Online Access: https://doi.org/10.1590/S0036-46651989000100005; https://doaj.org/article/e25a52aeba2c4f8cacac4434f9898b94

The present study evaluates the humoral and cellular immune responses in 35 volunteers submited to short antirabies vaccination schedules with the Fuenzalida & Palacios vaccine based on the administration of doses on non consecutive days. The volunteers were divided into two groups. The first group received a total number of five doses given on days 0, 4, 7, 20 and 35. The other group received four doses, the first one being a double dose given on day 0 and than three other single doses on days 7, 20 and 35. The evaluation of humoral immune response was carried out by serum neutralization (SN) and indirect immunofluorescense (IIF) tests, while the cellular immune response was evaluated by lymphoblastic transformation assay (LTA) and skin test (ST). According to our results these reduced schedules elicited early and effective humoral and cellulafimmune responses to rabies antigen suggesting that new reduced schedules should be extensively studied in order to give the proper bases to the proposition of changes in the current long-term schedule.