Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases
ABSTRACT Nosocomial bacterial infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP) is associated with high mortality in neurosurgical patients. There are few reports in the literature on meningitis caused by CRKP. We report two cases of CRKP meningitis after neurosurgery. The K. pn...
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ftdoajarticles:oai:doaj.org/article:e20fa4f108ed427193e0e202e15bcf2a 2024-09-09T19:25:09+00:00 Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases Yasmin Coelho Patrial Luma Petri Tortorelli Ana Claudia Souza Rodrigues Ivson Cassiano de Oliveira Santos Cláudia Elizabeth Volpe-Chaves Gislaine Souza Capato Gustavo Augusto Ribeiro Barbosa Ana Paula D’Alincourt Carvalho-Assef Marilene Rodrigues Chang 2019-12-01T00:00:00Z https://doi.org/10.1590/s1678-9946201961069 https://doaj.org/article/e20fa4f108ed427193e0e202e15bcf2a EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652019005000510&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/s1678-9946201961069 https://doaj.org/article/e20fa4f108ed427193e0e202e15bcf2a Revista do Instituto de Medicina Tropical de São Paulo, Vol 61 (2019) Meningitis Klebsiella pneumoniae Carbapenem-resistant Beta-lactamases Cerebrospinal fluid Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2019 ftdoajarticles https://doi.org/10.1590/s1678-9946201961069 2024-08-05T17:49:30Z ABSTRACT Nosocomial bacterial infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP) is associated with high mortality in neurosurgical patients. There are few reports in the literature on meningitis caused by CRKP. We report two cases of CRKP meningitis after neurosurgery. The K. pneumoniae identification and antimicrobial susceptibility testing were performed using the Vitek Compact System. Minimum inhibitory concentrations of polymyxin B were determined using the broth microdilution method. Molecular typing of K. pneumoniae isolates was investigated using multilocus sequence typing. Antimicrobial susceptibility testing showed that the K. pneumoniae isolates were multidrug resistant and co-produced extended-spectrum β-lactamases and KPC enzymes. The patients were treated with intrathecal polymyxin. Genetic polymorphism analyses revealed two different K. pneumoniae clones (ST1298 and ST2687), which were observed for the first time in CRKP infections. We recommend intravenous administration of intrathecal polymyxin for treating meningitis caused by multidrug-resistant K. pneumoniae . Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 61 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Meningitis Klebsiella pneumoniae Carbapenem-resistant Beta-lactamases Cerebrospinal fluid Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Meningitis Klebsiella pneumoniae Carbapenem-resistant Beta-lactamases Cerebrospinal fluid Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Yasmin Coelho Patrial Luma Petri Tortorelli Ana Claudia Souza Rodrigues Ivson Cassiano de Oliveira Santos Cláudia Elizabeth Volpe-Chaves Gislaine Souza Capato Gustavo Augusto Ribeiro Barbosa Ana Paula D’Alincourt Carvalho-Assef Marilene Rodrigues Chang Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases |
topic_facet |
Meningitis Klebsiella pneumoniae Carbapenem-resistant Beta-lactamases Cerebrospinal fluid Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
ABSTRACT Nosocomial bacterial infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP) is associated with high mortality in neurosurgical patients. There are few reports in the literature on meningitis caused by CRKP. We report two cases of CRKP meningitis after neurosurgery. The K. pneumoniae identification and antimicrobial susceptibility testing were performed using the Vitek Compact System. Minimum inhibitory concentrations of polymyxin B were determined using the broth microdilution method. Molecular typing of K. pneumoniae isolates was investigated using multilocus sequence typing. Antimicrobial susceptibility testing showed that the K. pneumoniae isolates were multidrug resistant and co-produced extended-spectrum β-lactamases and KPC enzymes. The patients were treated with intrathecal polymyxin. Genetic polymorphism analyses revealed two different K. pneumoniae clones (ST1298 and ST2687), which were observed for the first time in CRKP infections. We recommend intravenous administration of intrathecal polymyxin for treating meningitis caused by multidrug-resistant K. pneumoniae . |
format |
Article in Journal/Newspaper |
author |
Yasmin Coelho Patrial Luma Petri Tortorelli Ana Claudia Souza Rodrigues Ivson Cassiano de Oliveira Santos Cláudia Elizabeth Volpe-Chaves Gislaine Souza Capato Gustavo Augusto Ribeiro Barbosa Ana Paula D’Alincourt Carvalho-Assef Marilene Rodrigues Chang |
author_facet |
Yasmin Coelho Patrial Luma Petri Tortorelli Ana Claudia Souza Rodrigues Ivson Cassiano de Oliveira Santos Cláudia Elizabeth Volpe-Chaves Gislaine Souza Capato Gustavo Augusto Ribeiro Barbosa Ana Paula D’Alincourt Carvalho-Assef Marilene Rodrigues Chang |
author_sort |
Yasmin Coelho Patrial |
title |
Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases |
title_short |
Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases |
title_full |
Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases |
title_fullStr |
Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases |
title_full_unstemmed |
Post-neurosurgical meningitis caused by KPC-producing Klebsiella pneumoniae: report of two cases |
title_sort |
post-neurosurgical meningitis caused by kpc-producing klebsiella pneumoniae: report of two cases |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2019 |
url |
https://doi.org/10.1590/s1678-9946201961069 https://doaj.org/article/e20fa4f108ed427193e0e202e15bcf2a |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 61 (2019) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652019005000510&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/s1678-9946201961069 https://doaj.org/article/e20fa4f108ed427193e0e202e15bcf2a |
op_doi |
https://doi.org/10.1590/s1678-9946201961069 |
container_title |
Revista do Instituto de Medicina Tropical de São Paulo |
container_volume |
61 |
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1809894931042402304 |